oleptiss (DEFERASIROX)
- Oleptiss DT is a medication used to manage high levels of iron in the body caused by frequent blood transfusions. It falls into a class of medications that help eliminate excess iron from the body.
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What is Oleptiss?
Oleptiss tablets are used to lower high iron levels in the blood. You take it once a day on an empty stomach. Don't chew the tablet; mix it with water, orange juice, or apple juice instead. The main ingredient is Oleptiss. Other ingredients, which don't have a medical effect, include crospovidone (a substance that helps the tablet break down) and sodium starch glycolate (another tablet-helper). Important: Serious allergic reactions can happen during the first month of taking this medicine. See a doctor immediately if you experience any unusual symptoms like rash, swelling, or difficulty breathing.
What is the usual dose of Oleptiss?
Oleptiss is a medication used to treat iron overload. For adults, the usual starting dose is 20 mg per kilogram of body weight, per day (mg/kg/day). A kilogram is about 2.2 pounds. Children under 6 years old need a lower dose because their bodies don't process the medicine as well as adults'. They get about half the effect of an adult dose. People with kidney or liver problems may need a lower dose, determined by their doctor based on their individual health and iron levels. It's crucial to use the lowest effective dose to prevent serious side effects. The doctor will carefully monitor the patient.
How do I take Oleptiss?
Oleptiss can be taken on an empty stomach or with a small meal like a turkey sandwich or an English muffin with jelly and milk. If you miss a dose, take it later that day, at least two hours after a meal and half an hour before your next meal, unless it's almost time for your next dose or you can't take it on an empty stomach. There are no other special diet rules mentioned for taking Oleptiss.
For how long do I take Oleptiss?
Oleptiss is taken long-term until iron levels return to a safe range, as determined by blood tests. The duration depends on the ferritin levels and liver iron concentration (LIC) in the body. In NTDT patients, therapy may be stopped once LIC drops below 3 mg Fe/g dry weight. Regular monitoring is essential to determine when to continue, adjust, or stop treatment
What is Oleptiss used for?
Oleptiss is used to treat chronic iron overload in patients who require frequent blood transfusions, such as those with thalassemia, sickle cell disease, or myelodysplastic syndromes. It is also prescribed for non–transfusion-dependent thalassemia (NTDT) patients aged 10+ years to reduce iron buildup. Excess iron can cause severe organ damage, especially to the heart, liver, and pancreas. This medication helps prevent these complications
How long does it take for Oleptiss to start working?
Oleptiss starts removing iron immediately, but visible effects may take weeks to months. Most patients show a decrease in iron levels after 3 to 6 months of treatment. Regular blood tests help track progress and confirm the medication’s effectiveness. Symptoms related to iron overload, such as fatigue and skin discoloration, may improve over time
Is Oleptiss effective?
Oleptiss starts removing iron immediately, but visible effects may take weeks to months. Most patients show a decrease in iron levels after 3 to 6 months of treatment. Regular blood tests help track progress and confirm the medication’s effectiveness. Symptoms related to iron overload, such as fatigue and skin discoloration, may improve over time
How does one know if Oleptiss is working?
Oleptiss's effectiveness is tracked by checking blood ferritin levels and how well the patient is doing. The dose is changed based on kidney function (eGFR). eGFR is a measure of how well your kidneys filter blood. If your eGFR is below 40 mL/min/1.73 m² (meaning your kidneys aren't working very well), treatment stops. If it's between 40 and 60 mL/min/1.73 m², the starting dose is halved. If your eGFR drops by more than a third from your starting level, the daily dose is lowered by either 3.5mg/kg or 5mg/kg of your body weight, and your kidney function is checked again within a week. (mg/kg means milligrams per kilogram of body weight).
How does Oleptiss work?
Oleptiss binds to excess iron in the blood, forming a compound that is excreted in feces. This prevents iron buildup in major organs, particularly the liver, heart, and pancreas, reducing the risk of iron-related complications. By lowering serum ferritin and liver iron concentration, it helps protect the body from long-term damage. Continuous use is necessary to maintain safe iron levels
Who should avoid taking Oleptiss?
Patients with severe kidney or liver disease should not take Oleptiss, as it may worsen their condition. Those with low platelet counts (<50,000/mm³) or active gastric ulcers or bleeding disorders should use it with caution. Individuals allergic to Oleptiss or its components should avoid it. Doctors will evaluate potential risks before prescribing the medication
Can I take Oleptiss with vitamins or supplements?
Oleptiss can interact with some vitamins and supplements. Avoid taking it with aluminum-containing antacids (medicines that reduce stomach acid) – wait at least two hours between taking them. Melatonin (a sleep aid) and caffeine (a stimulant) may also interact negatively with Oleptiss. It's very important to keep a complete list of all your medicines, vitamins, and supplements and share it with your doctor or pharmacist. This helps them to avoid harmful interactions.
Can I take Oleptiss with other prescription drugs?
Oleptiss shouldn't be taken with aluminum-containing antacids (antacids that neutralize stomach acid). It can also weaken the effects of some other medicines. These include drugs broken down by the body's CYP3A4 enzyme (like cyclosporine, simvastatin, and birth control pills), drugs that boost UGT enzymes (which help the body process medications – like rifampicin, phenytoin, phenobarbital, and ritonavir), and bile acid sequestrants (medicines that bind to bile acids in the gut, like cholestyramine, colesevelam, and colestipol). If you take Oleptiss with UGT boosters or bile acid sequestrants, your doctor might need to increase your Oleptiss dose. This is because these other drugs can reduce the amount of Oleptiss your body absorbs, making it less effective. Your doctor will check your ferritin levels (a blood test measuring iron stores) and how you're responding to treatment to decide on the right dose.
Can Oleptiss be taken safely while pregnant?
Oleptiss is not recommended during pregnancy, as it may harm the fetus. Animal studies show evidence of birth defects and fetal toxicity, and human data is limited. Women taking this medication should use non-hormonal contraception to prevent pregnancy. If pregnancy occurs, the risks should be discussed with a doctor immediately
Can Oleptiss be taken safely while breastfeeding?
This medication, Oleptiss, might pass into breast milk. We don't know for sure how much or what effects it might have on a baby. Because it could seriously harm a nursing infant, you and your doctor need to decide: continue breastfeeding or take Oleptiss. You shouldn't do both. If you choose breastfeeding, you'll stop taking Oleptiss. Your doctor can help you make the best decision for you and your baby.
Is Oleptiss safe for the elderly?
Elderly patients have a higher risk of kidney and liver complications, so Oleptiss should be used cautiously. Frequent monitoring is necessary to detect any signs of organ toxicity or bleeding issues. Dose adjustments may be required based on kidney function and overall health status. Doctors will assess individual risks before prescribing the medication
How should I store Oleptiss?
Oleptiss tablets should be stored at room temperature (ideally 77°F or 25°C, but acceptable between 59°F/15°C and 86°F/30°C). Keep them in a dry place away from moisture, in the original tightly sealed container. This protects the medication from damage and keeps it safe for use. Children should not have access to the medication. When you have leftover Oleptiss, don't flush it down the toilet. Instead, take it to a medicine take-back program for safe disposal. This prevents environmental contamination and ensures proper waste management.
Does Oleptiss make people tired or drowsy?
Oleptiss can cause fatigue and weakness, which may affect more than 10% of users. If you experience excessive tiredness, consult your doctor for guidance on managing this side effect.
Does Oleptiss cause stomach upset?
Gastrointestinal side effects such as nausea, vomiting, and diarrhea can occur in over 10% of patients. If you experience persistent stomach upset, inform your healthcare provider for potential adjustments or treatments.
Does Oleptiss affect sleep?
Some users report insomnia or changes in sleep patterns, affecting over 10% of patients. If you notice significant sleep disturbances, discuss this with your doctor to explore possible solutions.
Does Oleptiss make it hard to think or concentrate?
Oleptiss may lead to difficulties with concentration and thinking, reported by more than 10% of users. If you encounter cognitive challenges, consult your healthcare provider for advice on managing these effects.
Does Oleptiss affect mood?
Mental health effects such as anxiety or mood swings can occur in over 10% of patients. If you experience mood changes, reach out to your doctor to discuss your symptoms and possible interventions.
Does Oleptiss interfere with sexual function?
Some individuals may experience a decrease in libido or difficulties with sexual performance, affecting more than 10% of users. If this occurs, talk to your healthcare provider about potential solutions.
Does Oleptiss affect appetite?
Oleptiss can lead to alterations in appetite, with more than 10% of users affected. If you notice significant changes in your appetite, consult your doctor for guidance.
Does Oleptiss cause weight gain?
Weight gain can occur in over 10% of patients taking Oleptiss. If you experience unexpected weight changes, discuss this with your healthcare provider for appropriate management strategies.
Does Oleptiss cause headaches?
Headaches may affect more than 10% of users. If you develop frequent headaches while taking Oleptiss, inform your doctor for potential treatment options.
Does Oleptiss limit driving?
Oleptiss can make you dizzy. This means you might feel unsteady or lightheaded. Because of this risk, you shouldn't drive a car or use any machinery (like power tools) until you know how the medication affects you personally. If you feel dizzy after taking Oleptiss, definitely avoid driving. Dizziness is a sensation of unsteadiness, often accompanied by a feeling that you might faint. It's important to be cautious and prioritize your safety and the safety of others. If you experience dizziness, contact your doctor.
Is it safe to drink alcohol while taking Oleptiss?
Drinking alcohol while taking Oleptiss is not recommended as it may increase the risk of liver damage and other side effects. It's best to limit or avoid alcohol and discuss any concerns with your doctor.
Is it safe to drink coffee or tea while taking Oleptiss?
Caffeinated beverages like coffee and tea do not significantly affect the safety or effectiveness of Oleptiss. However, moderation is advised, particularly if caffeine increases anxiety or insomnia.
Is it safe to exercise while taking Oleptiss?
Exercising while on Oleptiss is generally safe unless you experience severe fatigue or other side effects that limit physical activity. Always consult your healthcare provider before starting any new exercise regimen while on this medication.
What are Oleptiss possible harms and risks?
Oleptiss's most common side effects are diarrhea and nausea. More serious, but rarer, side effects can include: * **Serious allergic reactions:** A severe, life-threatening response to the drug, usually appearing within the first month. * **Bone marrow problems:** This can lead to low levels of white blood cells (which fight infection), platelets (which help blood clot), or worsening anemia (low red blood cells). These problems can be fatal. * **Severe skin reactions:** Serious skin problems that can be life-threatening. * **Hearing and vision problems:** This includes cataracts (clouding of the eye lens) and increased pressure inside the eye. If you experience any of these side effects, especially the serious ones, seek immediate medical attention. It's important to talk to your doctor about any concerns regarding Oleptiss.
Available in 3 variations
Oleptiss 90mg Tablet DT
Oleptiss 90mg Tablet DT
Deferasirox (90mg)
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Oleptiss 180mg Tablet DT
Oleptiss 180mg Tablet DT
Deferasirox (180mg)
strip of 10 tablet dt
Oleptiss 360mg Tablet DT
Oleptiss 360mg Tablet DT
Deferasirox (360mg)
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