grandem (GRANISETRON)
Introduction to Grandem
Grandem is a medication primarily used to prevent and treat nausea and vomiting, especially in patients undergoing chemotherapy, radiation therapy, or surgery. It is particularl... See More
What is Grandem?
Grandem is an anti-nausea medication used to prevent and treat nausea and vomiting caused by chemotherapy, radiation, or surgery. It works by blocking serotonin (a natural substance that can trigger vomiting) in the brain and gut. This helps reduce nausea and improves patient comfort during cancer treatment or post-surgery recovery.
What is the usual dose of Grandem?
For adults, the usual oral dose is 1-2 mg once or twice daily before chemotherapy. For intravenous use, 1 mg is given before chemotherapy. In children, dosing is based on weight, typically 40 mcg/kg IV. Doses may be adjusted depending on treatment type and patient response. Always follow the doctor’s recommendations.
How do I take Grandem?
Grandem is taken with or without food, usually an hour before chemotherapy or as directed by the doctor. If using an oral tablet, swallow it whole with water. If using an injection, a healthcare provider will administer it. Patients should avoid alcohol and excessive caffeine, as they may worsen side effects like dizziness or stomach upset.
For how long do I take Grandem?
Grandem is usually taken only on the day of chemotherapy or radiation therapy to prevent nausea. In some cases, it may be used for several days after treatment if nausea persists. For post-surgical nausea, it is typically given as a single dose. Long-term use is rare and should be discussed with a doctor.
What is Grandem used for?
Grandem is used to prevent and treat nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It helps cancer patients tolerate their treatments better and prevents dehydration or weakness from frequent vomiting. It is also used in hospitals for patients recovering from anesthesia after surgery.
How long does it take for Grandem to start working?
Grandem starts working within 30 minutes to 1 hour after taking a tablet or receiving an injection. Its effects last up to 24 hours, making it effective for preventing nausea throughout the day. Some patients may notice relief sooner, depending on their body's response and the severity of their symptoms.
Is Grandem effective?
Yes, Grandem is highly effective in preventing nausea and vomiting in chemotherapy and post-surgical patients. Studies show that it works in over 70-80% of patients, often better than older anti-nausea drugs. It is considered a first-choice medication for nausea relief in many cancer treatment protocols.
How does one know if Grandem is working?
Patients will notice a reduction in nausea and vomiting after taking Grandem. If it works effectively, they should feel more comfortable, able to eat and drink, and experience fewer episodes of vomiting. If nausea persists despite taking the medication, a doctor may adjust the dosage or try a different treatment.
How does Grandem work?
Grandem works by blocking serotonin (5-HT3 receptors) in the brain and gut. Serotonin is released during chemotherapy, radiation, or surgery, triggering nausea and vomiting. By stopping serotonin from acting on these receptors, Grandem effectively prevents nausea before it starts.
Who should avoid taking Grandem?
People who are allergic to Grandem or similar drugs (ondansetron, palonosetron) should not take it. It should be used with caution in patients with heart conditions, severe constipation, or liver problems. Pregnant women should consult a doctor before using it, as safety data is limited.
Can I take Grandem with vitamins or supplements?
Grandem has no major interactions with most vitamins and supplements. However, patients should inform their doctor about taking magnesium, potassium, or herbal supplements like St. John’s Wort, as they might affect how the medicine works or increase side effects like dizziness.
Can I take Grandem with other prescription drugs?
Grandem can interact with medications that affect serotonin levels, such as antidepressants (SSRIs, SNRIs), tramadol, and certain migraine drugs (triptans). Combining these may lead to serotonin syndrome, a rare but serious condition. It should also be used cautiously with heart medications due to the risk of irregular heartbeats.
Can Grandem be taken safely while pregnant?
Grandem is classified as Category B (animal studies show no harm, but human data is limited). It is generally considered safe during pregnancy if prescribed by a doctor, especially when nausea and vomiting are severe. However, it should only be used when clearly needed, and alternatives may be considered first.
Can Grandem be taken safely while breastfeeding?
There is limited data on Grandem use while breastfeeding. Since it is excreted in very small amounts in breast milk, it may be safe for short-term use. However, mothers should consult a doctor before using it, and monitor the baby for any signs of drowsiness, feeding issues, or irritability.
Is Grandem safe for the elderly?
Yes, Grandem is generally safe for elderly patients, but they may be more sensitive to side effects like constipation, dizziness, or heart rhythm changes. Doctors may prescribe lower doses to reduce risks. Regular monitoring is recommended to ensure the medicine remains effective and well-tolerated.
How should I store Grandem?
Grandem should be stored at room temperature (20-25°C), away from moisture, heat, and direct sunlight. Keep tablets in their original packaging and do not refrigerate the liquid or injection form unless instructed. Keep it out of reach of children and discard expired or unused medication properly.
Does Grandem make people tired or drowsy?
Grandem does not usually cause drowsiness, but in some cases, patients may experience fatigue (5-10%) or mild dizziness (5-10%). If you feel very tired while taking this medicine, avoid driving or operating heavy machinery. Drinking plenty of water and resting may help. If fatigue becomes severe or persistent, consult a doctor.
Does Grandem cause stomach upset?
Grandem may cause constipation (10-20%), abdominal pain (5-10%), or diarrhea (5-10%) in some patients. If constipation occurs, drinking water, eating fiber-rich foods, and mild physical activity may help. If diarrhea becomes severe or persistent, contact a doctor for advice, as dehydration could be a risk.
Does Grandem affect sleep?
Grandem is not known to cause major sleep disturbances, but some patients may experience insomnia (3-5%) or mild restlessness. If you have trouble sleeping, try taking the medicine in the morning rather than at night. If sleep problems continue, inform your doctor to discuss alternative options.
Does Grandem make it hard to think or concentrate?
Grandem does not usually affect cognitive function, but dizziness (5-10%) or headache (10-15%) may occur, making it harder to focus. If you feel mentally foggy or struggle to concentrate, avoid activities that require alertness. These effects should improve as your body adjusts to the medicine.
Does Grandem affect mood?
Mood changes with Grandem are rare, but some people report mild anxiety or restlessness (3-5%). This may be due to the body's response to nausea relief rather than the drug itself. If you experience significant mood changes, inform your doctor to discuss possible alternatives or adjustments in your treatment.
Does Grandem interfere with sexual function?
Grandem is not known to affect libido or sexual performance, as it primarily targets nausea receptors in the gut and brain. However, if nausea-related stress improves, some patients may experience better sexual well-being. If you notice any unusual sexual side effects, discuss them with your doctor.
Does Grandem affect appetite?
Grandem may increase appetite in some patients by reducing nausea, making it easier to eat. However, others might experience mild loss of appetite (3-5%) due to its effects on serotonin. If your appetite changes significantly, try eating small, frequent meals and consult a doctor if necessary.
Does Grandem cause weight gain?
Grandem does not directly cause weight gain, but patients may gain weight if their appetite improves after nausea relief. If weight gain is a concern, maintaining a balanced diet and regular physical activity can help. Any significant or sudden weight changes should be reported to a doctor.
Does Grandem cause headaches?
Yes, headache is a common side effect (10-15%) of Grandem. This may be due to changes in serotonin levels. Drinking water, resting, and using mild pain relievers like paracetamol may help. If headaches become severe or frequent, consult a doctor to adjust the dosage or consider an alternative medication.
Does Grandem limit driving?
Grandem does not usually impair driving ability, but dizziness (5-10%) or drowsiness (5-10%) may occur. If you feel dizzy or lightheaded after taking it, avoid driving or operating heavy machinery until the effects wear off. If symptoms persist, inform your doctor for further advice.
Is it safe to drink alcohol while taking Grandem?
Drinking alcohol while taking Grandem is not recommended, as it may increase dizziness, drowsiness, and stomach irritation. Occasional small amounts may be safe, but moderate to heavy drinking should be avoided. If you experience strong side effects after drinking alcohol, consult your doctor.
Is it safe to drink coffee or tea while taking Grandem?
Yes, but caffeine may worsen side effects like headache, dizziness, or restlessness in some patients. If you notice discomfort after drinking coffee or tea, consider reducing your intake. Herbal teas without caffeine may be a safer option if you need a warm drink.
Is it safe to exercise while taking Grandem?
Yes, moderate exercise is generally safe while taking Grandem. However, if you experience dizziness or fatigue, avoid strenuous workouts until you feel better. Staying hydrated and choosing low-impact activities like walking or stretching can help maintain fitness without worsening side effects.
What are Grandem possible harms and risks?
Common side effects include headache (10-15%), constipation (10-20%), dizziness (5-10%), and fatigue (5-10%). Rare but serious risks include allergic reactions, irregular heartbeat, or severe constipation. If any severe reactions occur, such as chest pain or trouble breathing, medical help should be sought immediately.
Available in 5 variations
Grandem 1 Tablet 6s
Granisetron (1mg)
strip of 6 tablets
Grandem MD Tablet 10s
Granisetron (1mg)
strip of 10 tablet md
Grandem MD Tablet 6s
Grandem MD Tablet 6s
Granisetron (1mg)
strip of 6 tablet md
Grandem Syrup 10ml
Granisetron (1mg/5ml)
bottle of 10 ml syrup
Grandem Injection 1ml
Granisetron (1mg)
vial of 1 ml injection
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