Rasagiline

What is Rasagiline used for?

Rasagiline is primarily indicated for the treatment of Parkinson's disease. It is used to manage motor symptoms such as tremors, stiffness, slowness of movement, and balance issues. Rasagiline can be prescribed as monotherapy in early Parkinson’s or as an adjunct therapy with levodopa in advanced stages to enhance symptom control and reduce motor fluctuations.

How does Rasagiline work?

Rasagiline works by inhibiting monoamine oxidase-B (MAO-B), an enzyme responsible for breaking down dopamine in the brain. By reducing dopamine breakdown, it helps increase and maintain dopamine levels, which are crucial for controlling movement. This mechanism helps alleviate motor symptoms like tremors, stiffness, and slowness of movement in Parkinson’s disease, where dopamine levels are naturally low.

Is Rasagiline effective?

Evidence supporting Rasagiline's effectiveness comes from clinical trials like the ADAGIO and TEMPO studies, which demonstrated significant improvement in Parkinson’s symptoms and motor function. Patients using Rasagiline showed delayed symptom progression and reduced motor fluctuations when combined with levodopa. Long-term studies confirmed its safety and efficacy in managing motor symptoms and enhancing the quality of life in Parkinson’s disease patients.

How does one know if Rasagiline is working?

The benefit of Rasagiline is evaluated by monitoring improvements in motor symptoms of Parkinson’s disease, such as reduced tremors, stiffness, slowness of movement, and better balance. Doctors may use standardized tools like the Unified Parkinson's Disease Rating Scale (UPDRS) to assess changes in symptoms. Patients' quality of life, daily functioning, and reduction in motor fluctuations are also key indicators of its effectiveness.

What is the usual dose of Rasagiline?

For adults, the usual dose of rasagiline is 1 mg orally once daily for Parkinson's disease, either as monotherapy or adjunct therapy. If used with levodopa, it may start at 0.5 mg once daily, increasing to 1 mg as needed. Rasagiline is not recommended for children under 18 years. Always consult a healthcare provider for dosing.

How do I take Rasagiline?

Rasagiline is typically taken once daily, with or without food, as directed by your doctor. People taking Rasagiline should avoid consuming large amounts of tyramine-rich foods, such as aged cheeses, cured meats, or fermented products, as these may cause a dangerous rise in blood pressure. Always follow your healthcare provider's instructions regarding diet and medication use.

For how long do I take Rasagiline?

Rasagiline is a medication used to treat Parkinson's disease. Studies have shown that it is effective in improving symptoms for up to 26 weeks. One study specifically looked at the effects of rasagiline over 26 weeks and found that it significantly improved motor function and reduced tremors.

How long does it take for Rasagiline to start working?

Rasagiline typically starts working within 1 to 2 weeks, though some patients may notice improvements in Parkinson’s symptoms sooner. However, the full effect may take several weeks to become apparent as the medication builds up in the system. Individual response times can vary, so it's important to follow your doctor’s guidance and give the treatment time to work.

How should I store Rasagiline?

Rasagiline should be stored at room temperature (between 20°C to 25°C or 68°F to 77°F) in a tight, light-resistant container. It should be kept away from moisture, heat, and direct sunlight. Ensure the medication is out of reach of children and never store it in the bathroom, as humidity can affect its effectiveness. Always follow the storage instructions provided by your pharmacist or healthcare provider.

Who should avoid taking Rasagiline?

Rasagiline is contraindicated in individuals taking MAO inhibitors, certain antidepressants, or opioid medications due to the risk of serotonin syndrome or hypertensive crisis. People with severe liver impairment should not use it. Warnings include avoiding tyramine-rich foods to prevent high blood pressure and monitoring for melanoma. Caution is advised for those with hallucinations, cardiovascular issues, or psychiatric conditions.

Can I take Rasagiline with other prescription drugs?

Rasagiline can interact with several prescription drugs. Key interactions include:

• MAO inhibitors (e.g., phenelzine, tranylcypromine) can cause a dangerous hypertensive crisis.
• SSRIs, SNRIs, and other antidepressants (e.g., fluoxetine, sertraline) increase the risk of serotonin syndrome.
• Levodopa may lead to increased involuntary movements (dyskinesia).
• Meperidine and other opioid pain medications can cause serotonin syndrome.

Patients should consult a doctor before combining Rasagiline with other medications.

Can I take Rasagiline with vitamins or supplements?

Rasagiline may interact with certain vitamins and supplements, particularly those containing tyramine (like aged cheeses or fermented products) which can cause a hypertensive crisis. St. John's Wort should be avoided, as it may reduce Rasagiline's effectiveness. Supplements with vitamin B6 could also interfere with the efficacy of Rasagiline when combined with levodopa. Always consult a healthcare provider before taking new supplements while on Rasagiline.

Can Rasagiline be taken safely while pregnant?

Rasagiline is classified as Category C during pregnancy, meaning its safety has not been well studied in pregnant women. Animal studies have shown potential fetal harm, but there is insufficient human data to confirm these risks. It should only be used during pregnancy if the potential benefit outweighs the potential risk to the fetus. Pregnant women or those planning to become pregnant should consult a doctor before using Rasagiline.

Can Rasagiline be taken safely while breastfeeding?

Rasagiline is not recommended during breastfeeding due to limited data on its excretion in breast milk and its potential effects on a nursing infant. The drug may pass into breast milk, and while no significant adverse effects have been documented, it is advised to consult a healthcare provider before breastfeeding while on Rasagiline. Alternative treatments may be considered to ensure the safety of both mother and baby.

Is Rasagiline safe for the elderly?

In clinical trials, about half of the participants were 65 or older. No significant safety differences were seen when compared to younger patients. However, elderly patients should be cautious about quickly standing up after sitting or lying down, especially at first. They should also be monitored for new or uncontrolled high blood pressure, and advised to avoid driving or dangerous activities if they experience drowsiness or unexpected sleepiness.

Is it safe to exercise while taking Rasagiline?

Exercise is safe while taking Rasagiline, but ensure you don’t experience dizziness, low blood pressure, or fatigue during physical activities. If you feel lightheaded, stop exercising and consult your doctor.

Is it safe to drink alcohol while taking Rasagiline?

Consuming alcohol with Rasagiline may increase the risk of side effects such as drowsiness or low blood pressure. It’s best to limit alcohol consumption while taking Rasagiline.