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Ramipril

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DRUG STATUS

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Approvals

US(FDA), UK(BNF)

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Essential Medicine

YES

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Teratogenicity

Unlisted

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Pharmaceutical Class

Angiotensin Converting Enzyme Inhibitor

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Drug Ingredient

Ramipril

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Summary

  • Ramipril is a prescription medication used to treat high blood pressure and heart failure. High blood pressure can make your heart work harder and can cause damage to your body. Heart failure means your heart isn't pumping blood as well as it should. Ramipril helps to lower blood pressure and improve blood flow.

  • Ramipril is a medicine that helps relax and widen blood vessels, making it easier for your heart to pump blood. It does this by blocking a substance in your body that normally tightens blood vessels. When your blood vessels stay relaxed, it lowers blood pressure and reduces strain on the heart.

  • Ramipril is usually taken once or twice a day, with or without food. Your doctor will start you on a low dose, usually between 1.25mg and 2.5mg once a day. They may gradually increase the dose over a few weeks until you reach the right amount for your condition. For the pill form, swallow the tablets or capsules whole with a drink of water.

  • Ramipril may cause some side effects, but most are mild. The most common ones are headache, dizziness, and tiredness. More serious side effects, though rare, include swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs, hoarseness, difficulty breathing or swallowing, and lightheadedness.

  • Ramipril is not recommended for use during pregnancy, particularly during the second and third trimesters, as it can harm the baby's kidneys and cause long-term damage. If you have diabetes, do not take it with aliskiren. Also, be careful if you're taking other blood pressure medicines, antidepressants, nitrates for chest pain, or medicines for an enlarged prostate.

Indications and Purpose

What is Ramipril used for?

Ramipril is a prescription medicine used to treat high blood pressure and heart failure. High blood pressure makes your heart work harder and can damage your body. Heart failure means your heart is not pumping blood as well as it should. Ramipril helps to lower blood pressure and improve blood flow.

How does Ramipril work?

Ramipril is a medicine that helps relax and widen blood vessels, making it easier for your heart to pump blood. It does this by blocking a substance in your body that normally tightens blood vessels. When your blood vessels stay relaxed, it lowers blood pressure and reduces strain on the heart. This can help prevent problems like heart attacks, strokes, or kidney damage.

Is Ramipril effective?

Evidence for Ramipril's Effectiveness:

  1. Blood Pressure Reduction: Lowers blood pressure effectively in mild to severe hypertension.
  2. HOPE Trial: Reduced heart attacks, strokes, and death by ~20-25% in high-risk patients.
  3. Kidney Protection: Preserves kidney function, especially in diabetes and hypertension.
  4. Heart Failure: Improves survival and reduces hospitalizations.
  5. Post-Heart Attack: Lowers risk of future cardiovascular events.

These studies confirm Ramipril’s efficacy in protecting the heart, kidneys, and overall cardiovascular health.

How does one know if Ramipril is working?

Your doctor will monitor your blood pressure and inquire about any side effects from your medication to determine the right dosage for you. They may also order blood tests to evaluate your kidney function and potassium levels.

Directions for Use

What is the usual dose of Ramipril?

For adults, the usual Ramipril dose ranges from 2.5mg to 20mg daily. It can be taken once or twice a day. The starting dose for high blood pressure is usually 2.5mg once a day, which can be adjusted based on how your blood pressure responds. The maximum dose is 5mg twice a day or 10mg once a day. This information does not include dosage for children.

How do I take Ramipril?

Ramipril is a pill or liquid medicine that you take by mouth. It's usually taken once or twice a day, with or without food. Swallow the pills whole with a drink of water, or measure out the liquid with a syringe or spoon provided with the medicine. If you are taking ramipril, it's important to talk to your doctor before using salt substitutes that contain potassium. Additionally, it's crucial to follow your doctor's instructions carefully if you are prescribed a low-salt or low-sodium diet.

For how long do I take Ramipril?

Ramipril is a medicine that helps control blood pressure. It is usually taken over a long period of time, often for the rest of a person's life. This is because high blood pressure often needs to be controlled for a long time to prevent serious health problems like heart attacks and strokes.

How long does it take for Ramipril to start working?

When taken once, doses of ramipril between 5 mg and 20 mg can lower blood pressure within 1 to 2 hours. The greatest reduction in blood pressure happens 3 to 6 hours after taking the medication.

How should I store Ramipril?

Keep this medicine at room temperature between 68°F to 77°F (20°C to 25°C). Keep it away from moisture and heat and out of the bathroom. Keep it tightly closed in the original container. Keep it out of children's reach.

Warnings and Precautions

Who should avoid taking Ramipril?

When you find out you're pregnant, stop taking ramipril capsules right away. Medicines that work directly on the renin-angiotensin system can harm or even kill an unborn baby.

Can I take Ramipril with other prescription drugs?

**Ramipril:** * Don't take with aliskiren if you have diabetes. * Don't take with valsartan and sacubitril. * Use carefully with water pills (diuretics), especially if you've recently started taking them. * Use carefully with other blood pressure medicines, antidepressants, nitrates for chest pain, or medicines for an enlarged prostate. * Use carefully with medicines that increase potassium in your blood, such as spironolactone or potassium supplements. * Use carefully with other medicines that affect the RAS system, such as ACE inhibitors or ARBs. * Use carefully with lithium, as it can increase lithium levels in your blood. * Use carefully with NSAIDs, as they can reduce ramipril's blood pressure-lowering effects. * Use carefully with mTOR inhibitors, as it can increase the risk of swelling.

Can I take Ramipril with vitamins or supplements?

When taking ramipril, it's crucial to inform your doctor about any other medications you're using, including herbs, vitamins, or supplements. This is because there's limited information on how these substances interact with ramipril. Unlike prescription medicines, herbal remedies and supplements haven't undergone the same rigorous testing. Therefore, it's essential to keep your healthcare provider fully informed to ensure safe and effective treatment.

Can Ramipril be taken safely while pregnant?

Ramipril is a medication that is not recommended for use during pregnancy, particularly during the second and third trimesters. It can harm the baby's kidneys and cause long-term damage. Your doctor may prescribe a different medication that is safe to take during pregnancy. 

Can Ramipril be taken safely while breastfeeding?

If your baby was born prematurely, you should not take ramipril. It's not known how much ramipril passes into breast milk, but it's likely to be a small amount. It is unlikely to cause side effects in your baby, but there is a very small risk that it could lower your baby's blood pressure. If you notice any unusual symptoms in your baby, such as poor feeding, unusual sleepiness, or paleness, contact your healthcare provider immediately.

Is Ramipril safe for the elderly?

Ramipril works just as well for all adults. However, older people (over 55) who have hardening of the arteries or diabetes and damage to organs like their kidneys may have worse kidney problems if they take ramipril with another medicine called telmisartan. It's best for them to avoid taking these medicines together. Also, make sure you're not dehydrated or have low sodium before starting ramipril, as it can cause low blood pressure.

Is it safe to exercise while taking Ramipril?

It's generally safe to exercise while on Ramipril. However, be mindful of dizziness or tiredness, especially when standing up quickly. If you feel lightheaded or weak, stop and consult your doctor before resuming physical activity.

Is it safe to drink alcohol while taking Ramipril?

Drinking alcohol while taking Ramipril may enhance its side effects, such as dizziness or low blood pressure. It’s recommended to limit alcohol intake and monitor for adverse effects