Pyridoxine
Vitamin B 6 Deficiency, Drug-Related Side Effects and Adverse Reactions ... show more
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DRUG STATUS
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
Unlisted
Pharmaceutical Class
Vitamin B6 Analog
Pyridoxine
Learn more about this medicine -
Click HereSummary
Pyridoxine, also known as vitamin B6, is used to treat or prevent vitamin B6 deficiency, which can lead to conditions like peripheral neuropathy, anemia, and seizures. It's also used to manage nausea and vomiting during pregnancy and to treat certain types of homocystinuria, a genetic disorder. Additionally, Pyridoxine is prescribed for certain neurological conditions.
Pyridoxine works as a coenzyme in various biochemical reactions in the body. It plays a key role in enzyme function, protein metabolism, and the production of neurotransmitters in the brain. It helps convert food into energy, supports brain function, and promotes healthy nerve function. Pyridoxine also plays a role in the production of red blood cells, which carry oxygen in the blood.
Adults and children 18 years and older typically take one 50 mg tablet of Pyridoxine daily. It can be taken with or without food as directed by your doctor. Always follow your healthcare provider's instructions for proper use and dosing.
Common side effects of Pyridoxine are generally mild and may include nausea, headache, and stomach upset. Significant adverse effects are rare but can include nerve damage or peripheral neuropathy with prolonged high doses, typically above 200 mg per day.
Pyridoxine should be used with caution in individuals with liver disease as high doses can worsen liver function. It's contraindicated in people who have had an allergic reaction to Pyridoxine. Prolonged use of high doses can lead to nerve damage or peripheral neuropathy. Always consult a healthcare provider before using Pyridoxine.
Indications and Purpose
What is Pyridoxine used for?
Pyridoxine (vitamin B6) is commonly indicated for treating or preventing vitamin B6 deficiency, which can lead to conditions like peripheral neuropathy, anemia, and seizures. It is also used to manage nausea and vomiting during pregnancy (morning sickness) and to treat certain types of homocystinuria, a genetic disorder. Pyridoxine is also prescribed for certain neurological conditions and as an adjunctive treatment in conditions like depression or carpal tunnel syndrome.
How does Pyridoxine work?
Pyridoxine (vitamin B6) works as a coenzyme in various biochemical reactions, particularly in amino acid metabolism, neurotransmitter synthesis, and the production of red blood cells. It helps convert food into energy, supports brain function by aiding the production of neurotransmitters like serotonin and dopamine, and promotes healthy nerve function. Pyridoxine also plays a role in hemoglobin production, which is crucial for carrying oxygen in the blood.
Is Pyridoxine effective?
The effectiveness of Pyridoxine in treating conditions like vitamin B6 deficiency, neuropathy, and morning sickness has been supported by clinical research. Studies have shown that Pyridoxine supplementation can alleviate symptoms of peripheral neuropathy and reduce the severity of nausea and vomiting during pregnancy. It also helps correct biochemical imbalances associated with vitamin B6 deficiency, supporting its role in improving overall health and managing specific health conditions.
How does one know if Pyridoxine is working?
The benefit of Pyridoxine is evaluated by monitoring the improvement of symptoms related to vitamin B6 deficiency, such as nerve pain, anemia, and fatigue. Blood tests may be conducted to check vitamin B6 levels and confirm deficiency. Additionally, healthcare providers assess clinical outcomes, such as reduced nausea during pregnancy or improved neurological function, to determine the effectiveness of treatment.
Directions for Use
What is the usual dose of Pyridoxine?
Most adults take one 50mg tablet each day. Kids under 12 need to ask a doctor how much to take.
How do I take Pyridoxine?
Pyridoxine can be taken with or without food, depending on personal preference. It is typically available in tablet or liquid form and should be taken according to the dosage prescribed by your healthcare provider. There are no specific food restrictions when taking Pyridoxine, but it is advisable to follow a balanced diet to ensure adequate vitamin intake. Always follow your healthcare provider's instructions for proper use and dosing.
For how long do I take Pyridoxine?
Pyridoxine can be taken with or without food. There are no specific food restrictions associated with this vitamin.
How long does it take for Pyridoxine to start working?
Pyridoxine typically starts showing effects within a few days to a week, depending on the condition being treated. For example, in cases of vitamin B6 deficiency or neuropathy, symptoms may begin to improve gradually as the body replenishes its vitamin levels. However, it may take a few weeks for the full benefits, especially for conditions like nerve damage or anemia.
How should I store Pyridoxine?
Keep in a cool, dry place between 59-86ºF. Protect from getting wet. Store in the original container to easily identify it. Use by the date on the package.
Warnings and Precautions
Who should avoid taking Pyridoxine?
Pyridoxine should be used with caution in individuals with liver disease, as high doses can worsen liver function. It is contraindicated in people who have had a hypersensitivity or allergic reaction to Pyridoxine. Prolonged use of high doses (above 200 mg/day) can lead to nerve damage or peripheral neuropathy. It is important to follow the recommended dosage and consult a healthcare provider before using Pyridoxine, especially for long periods.
Can I take Pyridoxine with other prescription drugs?
Pyridoxine can interact with several prescription medications. It may reduce the effectiveness of certain anticonvulsants, such as phenytoin, phenobarbital, and primidone, by affecting their metabolism. Pyridoxine can also interfere with the action of levodopa (used in Parkinson's disease) when taken without carbidopa, as it can reduce levodopa's effectiveness. Additionally, isoniazid (used for tuberculosis) may increase the risk of Pyridoxine deficiency. It's important to consult a healthcare provider if taking Pyridoxine alongside these medications.
Can I take Pyridoxine with vitamins or supplements?
Pyridoxine may interact with other vitamins and supplements, particularly with vitamin B12 and folic acid. High doses of Pyridoxine can interfere with the effectiveness of vitamin B12, potentially leading to nerve damage if deficiencies occur. Additionally, Pyridoxine may alter the metabolism of homocysteine when used with folic acid, which can affect cardiovascular health. It's important to consult a healthcare provider when combining Pyridoxine with other vitamins or supplements to avoid negative interactions.
Can Pyridoxine be taken safely while pregnant?
Pyridoxine is considered safe during pregnancy and is often used to treat nausea and vomiting (morning sickness). The recommended doses for pregnant women (usually up to 200 mg per day) do not pose significant risk to the fetus. Higher doses should only be used under medical supervision, as excessive amounts could potentially lead to adverse effects, such as nerve damage. Always consult a healthcare provider before using Pyridoxine during pregnancy.
Can Pyridoxine be taken safely while breastfeeding?
Pyridoxine is considered safe during lactation, as it is excreted into breast milk in small amounts. The typical doses used for treating deficiency or other conditions are not expected to cause harm to the nursing infant. However, high doses should be avoided, as they could potentially affect the infant. It is always advisable for breastfeeding mothers to consult a healthcare provider before taking Pyridoxine.
Is Pyridoxine safe for the elderly?
Elderly patients may require careful monitoring when using pyridoxine due to potential interactions with other medications they may be taking.
Is it safe to exercise while taking Pyridoxine?
Exercising while taking pyridoxine is typically safe and can help improve overall health. However, individuals should listen to their bodies and consult their healthcare provider before starting any new exercise regimen to ensure it's appropriate for their health status while on this supplement.
Is it safe to drink alcohol while taking Pyridoxine?
Moderate alcohol consumption does not significantly impact the effectiveness of pyridoxine. However, excessive alcohol intake can interfere with vitamin absorption and exacerbate side effects. It's best to consult your healthcare provider regarding alcohol use while taking this vitamin.
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