Promethazine
Perennial Allergic Rhinitis, Allergic Conjunctivitis ... show more
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DRUG STATUS
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
Unlisted
Pharmaceutical Class
Phenothiazine
Controlled Drug Substance
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Promethazine
Learn more about this medicine -
Click HereSummary
Promethazine is used to treat allergy symptoms like runny nose, sneezing, and itching. It's also used to prevent and treat nausea and vomiting caused by motion sickness or post-surgery. Additionally, it's used as a sleep aid for short-term insomnia treatment and as a sedative before or after surgery.
Promethazine works primarily as an antihistamine, blocking histamine, a substance in the body that triggers allergic reactions. It also has antiemetic (anti-nausea) and sedative properties, acting on the brain's neurotransmitter receptors to prevent nausea and induce drowsiness.
For adults, the typical dosage is 25 mg taken twice per day. The first dose should be taken 30-60 minutes before travel or bedtime. If needed, a second dose can be taken 8-12 hours later.
Common side effects include drowsiness, dizziness, dry mouth, constipation, and blurred vision. Serious side effects can include severe allergic reactions, respiratory depression, tremors, and low blood pressure.
Promethazine should not be used in children under 2 years old due to risk of fatal respiratory depression. It should be used with caution in patients with liver impairment or severe hypotension. It's also not recommended within two weeks of delivery as it can affect newborn's blood clotting.
Indications and Purpose
What is Promethazine used for?
Promethazine is indicated for treating allergy symptoms, nausea, vomiting, motion sickness, and as a sedative before surgery. It is also used to relieve symptoms of the common cold and to prevent nausea after surgery.
How does Promethazine work?
Promethazine works by blocking histamine receptors in the body, which helps reduce allergy symptoms. It also has sedative and antiemetic properties, making it effective for nausea and motion sickness.
Is Promethazine effective?
Promethazine is effective in treating allergy symptoms, nausea, and motion sickness by blocking histamine receptors. It is also used as a sedative. Its effectiveness is supported by its long-standing use and clinical studies.
How does one know if Promethazine is working?
The benefit of Promethazine is evaluated by monitoring the relief of symptoms it is prescribed for, such as allergy relief or nausea control. Regular follow-ups with a healthcare provider can help assess its effectiveness and adjust the dosage if needed.
Directions for Use
What is the usual dose of Promethazine?
For adults, the typical dose of Promethazine for allergies is 25 mg before bedtime, or 12.5 mg before meals and at bedtime. For children, the dose is usually 0.5 mg per pound of body weight, adjusted based on age and condition. Always follow your doctor's specific instructions.
How do I take Promethazine?
Promethazine can be taken with or without food. There are no specific food restrictions, but avoid alcohol as it can increase drowsiness. Always follow your doctor's instructions regarding dosage and timing.
For how long do I take Promethazine?
Promethazine is typically used for short-term relief of symptoms such as allergies, nausea, or motion sickness. The duration of use depends on the condition being treated and the doctor's recommendation. Always follow your doctor's guidance on how long to use this medication.
How long does it take for Promethazine to start working?
Promethazine typically starts working within 20 minutes after oral administration. Its effects can last between 4 to 6 hours, and sometimes up to 12 hours.
How should I store Promethazine?
Store Promethazine tablets and liquid at room temperature, away from heat and moisture. Suppositories should be kept in the refrigerator. Keep all forms of the medication out of reach of children and protect from light.
Warnings and Precautions
Who should avoid taking Promethazine?
Promethazine should not be used in children under 2 years due to the risk of fatal respiratory depression. It should be used cautiously in the elderly and those with respiratory issues. Avoid alcohol and other CNS depressants while taking this medication.
Can I take Promethazine with other prescription drugs?
Promethazine can interact with CNS depressants like alcohol, sedatives, and narcotics, increasing sedation. It may also interact with MAO inhibitors, increasing the risk of side effects. Always inform your doctor of all medications you are taking.
Can I take Promethazine with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Promethazine be taken safely while pregnant?
Promethazine should be used during pregnancy only if the potential benefits justify the risks. There is limited data on its safety in pregnancy, so it should be used under a doctor's supervision.
Can Promethazine be taken safely while breastfeeding?
Promethazine is excreted in breast milk and may cause irritability in the infant. It is generally not recommended for use while breastfeeding unless deemed necessary by a healthcare provider.
Is Promethazine safe for the elderly?
Elderly patients should use Promethazine with caution due to increased sensitivity to side effects like confusion and sedation. Lower doses are often recommended, and close monitoring by a healthcare provider is advised.
Is it safe to exercise while taking Promethazine?
Promethazine can cause drowsiness and dizziness, which may affect your ability to exercise safely. If you feel drowsy or dizzy, it is best to avoid strenuous activities or exercise until you know how the medication affects you.
Is it safe to drink alcohol while taking Promethazine?
Drinking alcohol while taking Promethazine can increase the sedative effects of the medication, leading to increased drowsiness and impaired motor skills. It is advised to avoid alcohol consumption while using this medication to prevent these enhanced effects.
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