Olmesartan
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DRUG STATUS
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Angiotensin 2 Receptor Blocker
Olmesartan
Learn more about this medicine -
Click HereSummary
Olmesartan is primarily used to treat high blood pressure in adults and children aged 6 years and older. It may also be used to treat heart failure and diabetic nephropathy in people with diabetes and high blood pressure.
Olmesartan works by blocking the action of angiotensin II, a natural substance that causes blood vessels to tighten. This helps relax and widen blood vessels, which lowers blood pressure and improves blood flow.
For adults, the usual starting dose of Olmesartan is 20 mg once daily, which may be increased to 40 mg if needed. For children aged 6 years and older, the starting dose is typically 10 mg once daily for those weighing 20 to 35 kg, and 20 mg for those weighing 35 kg or more.
Common side effects of Olmesartan include dizziness, headache, and fatigue. Serious side effects can include severe diarrhea, weight loss, and swelling of the face or extremities.
Olmesartan should not be used during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm. It is also contraindicated in patients with diabetes who are taking aliskiren. Patients with kidney or liver disease should use it with caution, and those with a history of angioedema should avoid it.
Indications and Purpose
What is Olmesartan used for?
Olmesartan is primarily indicated for the treatment of high blood pressure (hypertension) in adults and children aged 6 years and older. It may also be used to treat heart failure and diabetic nephropathy in people with diabetes and high blood pressure, although these uses should be discussed with a doctor.
How does Olmesartan work?
Olmesartan works by blocking the action of angiotensin II, a natural substance that causes blood vessels to tighten. By preventing this action, Olmesartan helps blood vessels relax and widen, allowing blood to flow more easily and reducing blood pressure.
Is Olmesartan effective?
Olmesartan is proven to effectively lower blood pressure in adults and children over 6 years old. It works by blocking substances that tighten blood vessels, allowing blood to flow more smoothly. Clinical trials have shown it reduces the risk of cardiovascular events like strokes and heart attacks by lowering blood pressure.
How does one know if Olmesartan is working?
The benefit of Olmesartan is evaluated by regularly monitoring blood pressure to ensure it is effectively lowered. Regular check-ups with your doctor will help assess how well the medication is working and if any adjustments to the dosage are needed.
Directions for Use
What is the usual dose of Olmesartan?
For adults, the usual starting dose of Olmesartan is 20 mg once daily. If needed, the dose can be increased to 40 mg once daily. For children aged 6 years and older, the starting dose is 10 mg once daily for those weighing 20 to <35 kg, and 20 mg once daily for those weighing ≥35 kg. The dose can be increased to a maximum of 20 mg for those under 35 kg and 40 mg for those 35 kg and over.
How do I take Olmesartan?
Olmesartan can be taken with or without food, usually once a day. To help remember, take it at the same time each day. Avoid using salt substitutes containing potassium without consulting your doctor. Follow any dietary recommendations provided by your healthcare provider.
For how long do I take Olmesartan?
Olmesartan is typically used as a long-term treatment for high blood pressure. It is important to continue taking it even if you feel well, as it helps manage blood pressure over time. Always follow your doctor's instructions regarding the duration of use.
How long does it take for Olmesartan to start working?
Olmesartan may start to lower blood pressure within the first week of treatment, but it can take up to 2 weeks to notice the full benefit. It's important to continue taking the medication as prescribed, even if you feel well.
How should I store Olmesartan?
Store Olmesartan in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program to prevent accidental ingestion by children or pets.
Warnings and Precautions
Who should avoid taking Olmesartan?
Olmesartan should not be used during pregnancy as it can cause harm or death to the fetus. It is also contraindicated in patients with diabetes who are taking aliskiren. Patients with kidney or liver disease should use it cautiously. Be aware of potential interactions with NSAIDs and potassium supplements.
Can I take Olmesartan with other prescription drugs?
Significant interactions include those with NSAIDs, which can reduce the effectiveness of Olmesartan and worsen kidney function. Potassium supplements and potassium-sparing diuretics can increase the risk of hyperkalemia. Aliskiren should not be used with Olmesartan in patients with diabetes due to increased risk of adverse effects.
Can I take Olmesartan with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Olmesartan be taken safely while pregnant?
Olmesartan should not be used during pregnancy, especially in the second and third trimesters, as it can cause fetal harm or death. If pregnancy is detected, discontinue use immediately and consult your doctor for alternative treatments. Human studies have shown risks of fetal renal dysfunction and other serious complications.
Can Olmesartan be taken safely while breastfeeding?
There is no information on the presence of Olmesartan in human milk, but it is secreted in the milk of lactating rats. Due to potential adverse effects on the nursing infant, it is recommended to either discontinue breastfeeding or the medication, considering the importance of the drug to the mother.
Is Olmesartan safe for the elderly?
Elderly patients may be more sensitive to the effects of Olmesartan, particularly the risk of hypotension (low blood pressure). It's important for elderly patients to have their blood pressure monitored regularly and to start with a lower dose if necessary. Consult your doctor for personalized advice.
Is it safe to exercise while taking Olmesartan?
Olmesartan does not typically limit the ability to exercise. However, it may cause dizziness or lightheadedness, especially when you first start taking it. If you experience these symptoms, be cautious when exercising and consult your doctor if you have concerns about your exercise routine.
Is it safe to drink alcohol while taking Olmesartan?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.