Olanzapine
DRUG STATUS
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
Unlisted
Pharmaceutical Class
Atypical Antipsychotic

Olanzapine
Learn more about this medicine -
Click HereSummary
Olanzapine is primarily used to treat mental illnesses such as schizophrenia and bipolar disorder. It is also sometimes used in combination with other treatments for depression.
Olanzapine works by affecting brain chemicals called dopamine and serotonin. It attaches to different parts of brain cells, influencing these chemicals' activity. It reaches its highest level in your blood about six hours after intake and stays in your system between 21 and 54 hours.
Olanzapine is typically taken once a day with or without food. For schizophrenia, the usual starting dose is 5 to 10 mg per day. For bipolar disorder, it's around 10 mg per day. The dose may vary depending on the condition being treated and individual factors.
Common side effects of Olanzapine include weight gain, diabetes or increased blood sugar, sedation or drowsiness, involuntary movements, increased cholesterol levels, and heart issues. It can also affect sexual function and make it hard to think clearly.
Olanzapine should not be used in older people with dementia due to increased risk of death. It's also not recommended during pregnancy unless absolutely necessary. It can interact with other medicines, so always inform your doctor about any other medications or supplements you're taking. Avoid alcohol while on Olanzapine and do not drive or operate machinery until you know how the medicine affects you.
Indications and Purpose
What is Olanzapine used for?
Olanzapine is used to treat:
- Schizophrenia
- Bipolar disorder
- Sometimes as an adjunct for depression when other treatments are not sufficient.
How does Olanzapine work?
Olanzapine is a medicine used to treat mental illness. Exactly how it works isn't fully understood, but it seems to affect brain chemicals called dopamine and serotonin. It attaches to different parts of brain cells, influencing these chemicals' activity. After you take it by mouth, the medicine reaches its highest level in your blood about six hours later. Your body breaks down most of it, with only a small amount leaving your body unchanged in your urine. The medicine stays in your system for a long time—between 21 and 54 hours.
Is Olanzapine effective?
Yes, Olanzapine is generally considered effective in managing the symptoms of schizophrenia, bipolar disorder, and as an adjunct for depression.
How does one know if Olanzapine is working?
If Olanzapine is working, you may notice improvements such as:
- Reduced hallucinations or delusions (for schizophrenia)
- Reduced mood swings (for bipolar disorder)
- Improved mood (for depression)
Directions for Use
What is the usual dose of Olanzapine?
- For adults: The usual starting dose for schizophrenia is 5 to 10 mg per day, which may be increased gradually based on individual response.
- For bipolar disorder, the starting dose is usually around 10 mg per day.
- The dose may vary depending on the condition being treated and individual factors
How do I take Olanzapine?
- Olanzapine is typically taken once a day, with or without food.
- It can be taken as a tablet or disintegrating tablet.
- Always follow the specific instructions provided by your doctor.
For how long do I take Olanzapine?
The duration depends on your condition. For chronic conditions like schizophrenia or bipolar disorder, Olanzapine may be taken long-term, but always follow your doctor's guidance.
How long does it take for Olanzapine to start working?
Olanzapine may start to have noticeable effects within 1 to 2 weeks, but it can take several weeks to reach its full effect.
How should I store Olanzapine?
Keep your olanzapine pills in a cool, dry place, away from sunlight. The best temperature is between 68 and 77 degrees Fahrenheit (20 to 25 degrees Celsius).
Warnings and Precautions
Who should avoid taking Olanzapine?
Olanzapine is a strong medicine with serious side effects. Older people with dementia have a higher risk of death while taking it. It can also cause high blood sugar, unhealthy cholesterol and fats, and weight gain. In rare cases, it can lead to a life-threatening condition called Neuroleptic Malignant Syndrome (NMS), causing high fever and stiff muscles. Don't drink alcohol or drive until you know how the medicine affects you. Tell your doctor right away if you have uncontrollable movements or signs of dehydration like sweating a lot, dry mouth, or extreme thirst.
Can I take Olanzapine with other prescription drugs?
Olanzapine is a medicine that can interact badly with other medicines. Some medicines, like fluvoxamine, make olanzapine stay in your body longer, so you might need a lower dose. Others, such as carbamazepine, make your body get rid of olanzapine faster. Olanzapine can also make blood pressure medicine work better and can lessen the effects of medicines for Parkinson's disease. If you take charcoal, it can stop your body from absorbing much of the olanzapine. Finally, taking olanzapine with other medicines that dry you out can increase your risk of bad stomach problems.
Can I take Olanzapine with vitamins or supplements?
- Certain vitamins or supplements, especially those affecting blood sugar or cholesterol, should be used cautiously.
- Always inform your doctor about any supplements you're taking.
Can Olanzapine be taken safely while pregnant?
Olanzapine should only be used during pregnancy if the benefit outweighs the risk. It is not recommended during pregnancy unless absolutely necessary.
Can Olanzapine be taken safely while breastfeeding?
Olanzapine, a medicine some mothers take, can get into breast milk. Babies who are breastfed might get sleepy, fussy, feed poorly, or have shaky movements because of it. If your baby shows any of these signs, tell a doctor right away. Doctors will weigh the good things about breastfeeding against the risks to the baby before deciding what's best.
Is Olanzapine safe for the elderly?
For older people with dementia who also have mental problems like hallucinations, using the drug olanzapine is risky. Studies show they're much more likely to die while taking it than if they don't take any medicine. This increased risk also applies to similar drugs. Olanzapine isn't even supposed to be used for this group. It also raises the chances of strokes and other blood vessel problems in the brain. If an older person needs this kind of medicine, doctors should start with a very low dose.
Is it safe to exercise while taking Olanzapine?
- Exercise is generally safe, but be cautious of dizziness or tiredness due to the sedating effects of Olanzapine. Always check with your doctor.
Is it safe to drink alcohol while taking Olanzapine?
Olanzapine is a medicine. Alcohol is a drug. Taking them together can make you very sleepy and dizzy, especially when you stand up quickly. This is because they both affect your blood pressure. It's best to avoid alcohol while you're on olanzapine.