Lenalidomide

What is Lenalidomide used for?

Lenalidomide is primarily used to treat multiple myeloma (a type of blood cancer), myelodysplastic syndromes (MDS), and mantle cell lymphoma (MCL). It helps slow the growth of cancer cells, boosts the immune system, and prevents tumors from forming new blood vessels.

How does Lenalidomide work?

Lenalidomide works in multiple ways: it modifies the immune system, prevents tumor blood vessel formation, and slows cancer cell growth. It enhances the body's ability to fight abnormal cells while reducing inflammation and stopping cancer cells from spreading.

Is Lenalidomide effective?

Yes, clinical studies show lenalidomide improves survival rates and slows cancer progression, especially in multiple myeloma and MDS. It works best when combined with other treatments like dexamethasone or chemotherapy. However, effectiveness varies based on individual response.

How does one know if Lenalidomide is working?

Doctors monitor blood tests, imaging scans, and symptom improvement to check effectiveness. In multiple myeloma, a decrease in M-protein levels indicates progress. In MDS, improved blood counts suggest a positive response. Symptoms like fatigue and pain may also improve over time.

What is the usual dose of Lenalidomide?

The dose depends on the condition:

• Multiple Myeloma: 25 mg once daily for 21 days in a 28-day cycle.
• MDS: 10 mg once daily.
• MCL: 25 mg once daily for 21 days in a 28-day cycle.Dosage adjustments may be needed based on kidney function and side effects.

How do I take Lenalidomide?

Take lenalidomide by mouth, with or without food, at the same time daily. Swallow the capsule whole with water; do not break or chew it. Avoid handling broken or crushed capsules. Women of childbearing age must use effective contraception due to serious birth defects risk.

For how long do I take Lenalidomide?

The treatment duration varies based on the condition and response. For multiple myeloma, it is taken long-term with periodic breaks. For MDS or MCL, treatment continues as long as it is effective and tolerated. The doctor will monitor and adjust treatment based on progress.

How long does it take for Lenalidomide to start working?

Lenalidomide does not provide instant relief . It may take weeks to months before significant improvements are seen. Blood tests and regular check-ups help track progress. Patients should continue taking it as prescribed, even if results are not immediately noticeable.

How should I store Lenalidomide?

Store lenalidomide at room temperature (20–25°C), away from heat, moisture, and direct sunlight. Keep it in its original container and out of reach of children. Do not handle broken capsules, as the powder can be harmful if inhaled or touched.

Who should avoid taking Lenalidomide?

• Pregnant women (due to severe birth defects).
• People with severe kidney disease, unless adjusted by a doctor.
• Patients with a history of blood clots (high clotting risk).
• Those allergic to lenalidomide or similar drugs like thalidomide.

Can I take Lenalidomide with other prescription drugs?

Lenalidomide interacts with blood thinners (warfarin, aspirin), steroids, and some antibiotics. Combining it with other drugs that affect the immune system or blood cells may increase side effects. Always inform your doctor about all medications you take.

Can I take Lenalidomide with vitamins or supplements?

Certain supplements, especially vitamin K, fish oil, and herbal blood thinners, may increase bleeding risk. Always consult a doctor before taking any supplements, as they may interfere with lenalidomide’s effects or increase side effects.

Can Lenalidomide be taken safely while pregnant?

No! Lenalidomide causes severe birth defects or miscarriage. Women of childbearing age must take two forms of birth control and undergo pregnancy tests before and during treatment. It should be completely avoided during pregnancy.

Can Lenalidomide be taken safely while breastfeeding?

No, lenalidomide should not be used while breastfeeding. It may pass into breast milk and harm the baby. If treatment is necessary, breastfeeding must be stopped. Consult a doctor for alternative feeding options.

Is Lenalidomide safe for the elderly?

Yes, but elderly patients have a higher risk of blood clots, low blood counts, and infections. Kidney function is often reduced with age, requiring dose adjustments. Close monitoring helps minimize risks.

Is it safe to exercise while taking Lenalidomide?

Yes, but moderate exercise is recommended. Light activities like walking, yoga, or stretching can help improve energy levels, mood, and circulation. Avoid intense workouts if you feel fatigued or dizzy. Listen to your body, and consult your doctor before starting or adjusting your exercise routine.

Is it safe to drink alcohol while taking Lenalidomide?

It’s not recommended to drink alcohol while on lenalidomide. Alcohol can increase dizziness, drowsiness, and liver strain, making side effects worse. If you choose to drink occasionally, limit intake and monitor how you feel. Always check with your doctor before drinking alcohol while on this medication.