Irbesartan
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DRUG STATUS
Approvals
US(FDA)
Essential Medicine
NO
Teratogenicity
N/A
Pharmaceutical Class
Angiotensin 2 Receptor Blocker
Irbesartan
Know More About This Medicine -
Click HereSummary
Irbesartan is used to treat high blood pressure, also known as hypertension, and diabetic nephropathy, a type of kidney disease that occurs in people with type 2 diabetes.
Irbesartan works by blocking a substance in the body called angiotensin II that causes blood vessels to tighten. This allows blood vessels to relax and widen, improving blood flow and reducing blood pressure.
Irbesartan is typically taken orally once a day. The usual starting dose for adults is 150 mg, which can be increased to a maximum of 300 mg if needed.
Common side effects of Irbesartan include diarrhea, heartburn, and excessive tiredness. More serious side effects can include swelling of the face, throat, or tongue, difficulty breathing, and severe dizziness.
Irbesartan should not be used during pregnancy, especially in the second and third trimesters, as it can harm the developing fetus. It's also contraindicated in patients with diabetes who are taking a medication called aliskiren. Patients with a history of hypersensitivity to any component of the medication should avoid it.
Indications and Purpose
What is Irbesartan used for?
Irbesartan is indicated for the treatment of high blood pressure and diabetic nephropathy in patients with type 2 diabetes. It helps lower blood pressure and slows the progression of kidney disease, reducing the risk of cardiovascular events like heart attacks and strokes.
How does Irbesartan work?
Irbesartan works by blocking the action of angiotensin II, a natural substance that causes blood vessels to tighten. By preventing this action, Irbesartan helps blood vessels relax and widen, allowing blood to flow more easily and reducing blood pressure.
Is Irbesartan effective?
Irbesartan has been shown in clinical trials to effectively lower blood pressure and reduce the risk of cardiovascular events such as stroke and heart attack. It is also effective in slowing the progression of kidney disease in patients with type 2 diabetes and hypertension. These benefits are primarily due to its ability to block substances that tighten blood vessels, allowing smoother blood flow.
How does one know if Irbesartan is working?
The benefit of Irbesartan is evaluated by regularly monitoring blood pressure to ensure it is within the target range. For patients with diabetic nephropathy, kidney function tests are also conducted to assess the medication's effectiveness in slowing disease progression. Regular follow-ups with a healthcare provider are essential.
Directions for Use
What is the usual dose of Irbesartan?
For adults, the usual starting dose of Irbesartan is 150 mg once daily, which can be increased to a maximum of 300 mg once daily if needed to control blood pressure. For children, the safety and efficacy of Irbesartan have not been established, and no specific dosage recommendations are available. Always follow your doctor's advice for dosing.
How do I take Irbesartan?
Irbesartan is taken as a tablet once daily, with or without food. It is important to take it at the same time each day. Avoid using salt substitutes containing potassium unless advised by your doctor. Follow any dietary recommendations provided by your healthcare provider.
For how long do I take Irbesartan?
Irbesartan is typically used as a long-term treatment for high blood pressure and diabetic nephropathy. It is important to continue taking it even if you feel well, as it helps manage your condition over time. Always follow your doctor's instructions regarding the duration of use.
How long does it take for Irbesartan to start working?
It may take about 2 weeks to notice the full benefit of Irbesartan in lowering blood pressure. However, some effects may be observed sooner. Continue taking the medication as prescribed, even if you feel well.
How should I store Irbesartan?
Store Irbesartan in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program, not by flushing it down the toilet.
Warnings and Precautions
Who should avoid taking Irbesartan?
Irbesartan should not be used during pregnancy, especially in the second and third trimesters, as it can harm the fetus. It is contraindicated in patients with diabetes who are also taking aliskiren. Patients with kidney or liver issues should use it cautiously. It may cause dizziness, so getting up slowly from sitting or lying positions is advised.
Can I take Irbesartan with other prescription drugs?
Irbesartan can interact with potassium supplements, NSAIDs like ibuprofen, and lithium, potentially leading to increased potassium levels or lithium toxicity. It should not be combined with aliskiren in diabetic patients. Always inform your doctor about all medications you are taking to avoid interactions.
Can I take Irbesartan with vitamins or supplements?
Irbesartan may interact with potassium supplements, leading to high potassium levels. It is important to consult your doctor before taking any new vitamins or supplements while on Irbesartan to avoid potential interactions.
Can Irbesartan be taken safely while pregnant?
Irbesartan is not recommended during pregnancy, especially in the second and third trimesters, as it can cause fetal harm, including kidney issues and death. If pregnancy is detected, discontinue use immediately and consult a doctor for alternative treatments.
Can Irbesartan be taken safely while breastfeeding?
There is no available data on the presence of Irbesartan in human milk, but it is secreted in the milk of lactating rats. Due to potential adverse effects on the nursing infant, Irbesartan is not recommended for breastfeeding women. Consult your doctor for alternative treatments.
Is Irbesartan safe for the elderly?
Elderly patients may be more sensitive to the effects of Irbesartan, but no specific dosage adjustment is usually necessary. However, starting with a lower dose, such as 75 mg, may be considered for those over 75 years old. Regular monitoring of blood pressure and kidney function is recommended.
Is it safe to exercise while taking Irbesartan?
Irbesartan does not typically limit the ability to exercise. However, it may cause dizziness or lightheadedness, especially when you first start taking it. If you experience these symptoms, be cautious when exercising and consult your doctor for advice.
Is it safe to drink alcohol while taking Irbesartan?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
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