Indomethacin
Rheumatoid Arthritis, Ankylosing Spondylitis ... show more
DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
NO
Teratogenicity
Unlisted
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug

Indomethacin
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Click HereSummary
Indomethacin is used for treating conditions that cause pain, swelling, redness, and fever. It's often used for arthritis pain, stiff achy joints, period cramps, and other short-term pains. It can also help reduce joint swelling and improve mobility in patients with arthritis.
Indomethacin works by inhibiting the synthesis of prostaglandins, substances in the body that cause inflammation, pain, and fever. It helps to reduce these symptoms but doesn't cure the underlying condition causing them.
Adults typically take 150 to 200 milligrams of Indomethacin daily. For children over two, the dose is determined based on their weight, but it should not exceed 150-200 mg per day. The medicine is taken orally, usually with food or antacids to reduce stomach side effects.
Common side effects of Indomethacin include upset stomach, nausea, vomiting, indigestion, heartburn, and stomach pain. Less common but serious side effects include ulcers, bleeding in the stomach or intestines, and liver problems. It can also cause drowsiness, fatigue, and dizziness.
Indomethacin should not be used during pregnancy, especially after 20 weeks. It can also cause serious problems like heart attacks, strokes, and stomach ulcers. It's important to avoid alcohol while taking this medicine to lower the risk of stomach ulcers and bleeding. You should also tell your doctor about any other medicines you're taking as Indomethacin can interact with them.
Indications and Purpose
What is Indomethacin used for?
Indomethacint help with aches, swelling, and pain. They're used for things like arthritis pain (stiff, achy joints), period cramps, and other pains that don't last long. They work by reducing both the pain you feel and the swelling causing it.
How does Indomethacin work?
Indomethacin is a medicine that helps with pain, swelling, redness, and fever. It works by stopping the body from making substances that cause these problems. It makes you feel better, but it doesn't actually cure whatever is making you sick. You take it by mouth, and it works quickly. Your body gets rid of it fairly fast, too.
Is Indomethacin effective?
Indomethacin effectively reduces inflammation, fever, and pain in various conditions. It has shown benefits in reducing joint swelling, stiffness, and improving mobility in arthritis patients.
How does one know if Indomethacin is working?
To know if Indomethacin is working check regularly for Improvement in symptoms like reduced pain, swelling, and fever indicates effectiveness. Regular follow-ups are advised for chronic conditions.
Directions for Use
What is the usual dose of Indomethacin?
Adults usually take 150 to 200 milligrams (mg) of this medicine daily. For children over two, the doctor will figure out the right dose based on their weight, making sure it's not more than 150-200 mg total per day. It's very important for doctors to watch children closely when they take this medicine.
How do I take Indomethacin?
Take Indomethacin capsules orally, with food or antacids, to reduce gastrointestinal side effects. Follow the prescribed dose and avoid taking it longer than directed due to potential side effects.
For how long do I take Indomethacin?
Use the medicine indomethacin for as short a time as needed.
The duration varies by condition:
- Acute conditions like gout or bursitis: 7-14 days.
- Chronic conditions like arthritis: Long-term use with periodic monitoring
How long does it take for Indomethacin to start working?
Pain relief occurs within 2-4 hours for acute conditions. Effects on inflammation and fever may take longer.
How should I store Indomethacin?
Store at 20˚-25˚C (68˚-77˚F) in a tightly closed container. Keep away from excessive heat and moisture.
Warnings and Precautions
Who should avoid taking Indomethacin?
NSAIDs like ibuprofen or naproxen can be risky. They might cause serious problems like heart attacks, strokes, bleeding, stomach ulcers, or severe allergic reactions. Don't take them if you've recently had a heart attack or surgery. If you're pregnant, avoid them after 30 weeks, and talk to your doctor if you need them between 20 and 30 weeks. Get immediate medical help if you develop a rash, fever, or trouble breathing or swallowing after taking them. Never take NSAIDs with other NSAIDs or aspirin.
Can I take Indomethacin with other prescription drugs?
Taking aspirin (3.6 grams a day) can lower the amount of indomethacin in your blood by about 20%. Another medicine, diflunisal, can raise the amount of indomethacin in your blood. Doctors aren't sure exactly what these effects mean for your health. It's important to tell your doctor about all the medicines you take.
Can I take Indomethacin with vitamins or supplements?
NSAIDs (like ibuprofen or naproxen) can be risky if you take them with other medicines, vitamins, or supplements. These combinations can sometimes cause serious problems. To be safe, always tell your doctor or pharmacist about *everything* you're taking before starting NSAIDs—even vitamins or herbal remedies.
Can Indomethacin be taken safely while pregnant?
Indomethacin is a medicine that shouldn't be used during pregnancy, especially after 20 weeks. If it absolutely must be used between 20 and 30 weeks, the doctor will give the smallest amount for the shortest time possible. Using it after 30 weeks or longer can harm the baby's heart and kidneys. There's not enough information to know exactly how risky it is.
Can Indomethacin be taken safely while breastfeeding?
Breastfeeding is generally good for babies, helping them grow and stay healthy. However, if a mother takes a medication like Indomethacin, it might get into her breast milk. A study showed that in most mothers taking Indomethacin, the amount in their breast milk was very low and likely wouldn't harm the baby. Still, it's crucial to talk to a doctor. They can assess the benefits of breastfeeding for your baby against any possible risks from the medication, and give the best advice for your situation.
Is Indomethacin safe for the elderly?
Older adults (65 and up) are more likely to have serious problems with their heart, stomach, and kidneys if they take NSAIDs like indomethacin. Start with the smallest amount of medicine needed, watch closely for any side effects, and reduce the dose or stop the medicine if problems occur. Indomethacin can also cause confusion or mental changes in older people. Regular kidney function checks are important.
Is it safe to exercise while taking Indomethacin?
Exercise is generally safe but be cautious if you experience dizziness or fatigue. Avoid strenuous activity if gastrointestinal or cardiovascular symptoms occur.
Is it safe to drink alcohol while taking Indomethacin?
This medicine (an NSAID) can cause ulcers or bleeding in your stomach. Drinking alcohol also increases the risk of stomach ulcers and bleeding. So, if you take this medicine, it's best to avoid alcohol to lower your chances of getting a stomach ulcer or bleeding.