Glipizide
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DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
NO
Teratogenicity
Unlisted
Pharmaceutical Class
Sulfonylurea
Glipizide
Know More About This Medicine -
Click HereSummary
Glipizide is used to control high blood sugar levels in people with type 2 diabetes. It helps prevent complications like nerve damage, kidney issues, and heart problems.
Glipizide stimulates pancreatic beta cells to release more insulin. This helps lower blood sugar by promoting glucose uptake into cells and reducing its release from the liver.
The usual starting dose is 5 mg once daily before breakfast, with a maximum daily dose of 40 mg. Some patients may require divided doses for better glucose control. Glipizide is an oral medication.
Common side effects include low blood sugar (hypoglycemia), nausea, and diarrhea. Rare but serious risks are liver issues or blood disorders.
Avoid Glipizide if you have type 1 diabetes, severe liver or kidney problems, or a sulfa drug allergy. Pregnant or breastfeeding women should consult their doctor before use. Alcohol can increase the risk of low blood sugar with Glipizide.
Indications and Purpose
What is Glipizide used for?
Glipizide is prescribed to control high blood sugar levels in people with type 2 diabetes. It helps prevent complications like nerve damage, kidney issues, and heart problems.
How does Glipizide work?
Glipizide stimulates pancreatic beta cells to release more insulin. This helps lower blood sugar by promoting glucose uptake into cells and reducing its release from the liver.
Is Glipizide effective?
Yes, Glipizide effectively lowers blood sugar in type 2 diabetes, especially when combined with a healthy diet, exercise, and other medications if necessary.
How does one know if Glipizide is working?
Monitoring blood sugar levels shows if Glipizide is effective. Signs include stable glucose levels within your target range and a reduction in diabetes symptoms like frequent urination or excessive thirst.
Directions for Use
What is the usual dose of Glipizide?
The usual starting dose is 5 mg once daily before breakfast, with a maximum daily dose of 40 mg. Some patients may require divided doses for better glucose control.
How do I take Glipizide?
Take Glipizide 30 minutes before a meal, usually breakfast. Swallow it whole with water, and avoid skipping meals to prevent low blood sugar (hypoglycemia).
For how long do I take Glipizide?
Glipizide is usually taken long-term to manage blood sugar levels in type 2 diabetes. Your doctor will guide you on the duration based on your condition and response to treatment.
How long does it take for Glipizide to start working?
Glipizide begins lowering blood sugar about 30 minutes after taking it, with full effects occurring within 1 to 3 hours after dosing.
How should I store Glipizide?
Store Glipizide at room temperature, away from moisture, heat, and direct sunlight. Keep it out of reach of children and pets.
Warnings and Precautions
Who should avoid taking Glipizide?
Avoid Glipizide if you have type 1 diabetes, severe liver or kidney problems, or a sulfa drug allergy. Pregnant or breastfeeding women should consult their doctor before use.
Can I take Glipizide with other prescription drugs?
Glipizide interacts with medications like beta-blockers, NSAIDs, and antifungal drugs. These can increase or decrease its effects. Inform your doctor of all your medications to avoid complications.
Can I take Glipizide with vitamins or supplements?
Most vitamins are safe, but avoid supplements that raise blood sugar, like glucosamine. Always discuss with your doctor before combining supplements with Glipizide.
Can Glipizide be taken safely while pregnant?
Glipizide is not typically recommended during pregnancy due to potential risks. Insulin is usually preferred for managing diabetes in pregnant women.
Can Glipizide be taken safely while breastfeeding?
Glipizide may pass into breast milk in small amounts. Consult your doctor to assess the risks before breastfeeding while on this medication.
Is Glipizide safe for the elderly?
Glipizide can be used by elderly patients but with caution, as they are more prone to hypoglycemia. Regular monitoring and a lower starting dose are often recommended.
Is it safe to exercise while taking Glipizide?
Yes, exercise is beneficial for diabetes management. However, check your blood sugar before and after workouts to prevent hypoglycemia. Carry snacks for emergencies during physical activity.
Is it safe to drink alcohol while taking Glipizide?
Alcohol can increase the risk of low blood sugar with Glipizide. If you choose to drink, limit alcohol intake and monitor blood sugar closely to avoid complications.
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