Desmopressin
Neurogenic Diabetes Insipidus, Thrombocytopenia ... show more
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DRUG STATUS
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Unlisted
Pharmaceutical Class
Factor VIII Activator and Vasopressin Analog
Controlled Drug Substance
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Desmopressin
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Click HereSummary
Desmopressin is used for treating conditions like central diabetes insipidus, which is characterized by excessive thirst and urination, and primary nocturnal enuresis, a condition in which children wet the bed at night. It's also used for certain bleeding disorders like hemophilia A or von Willebrand's disease.
Desmopressin mimics the antidiuretic hormone (ADH) in your body. It signals the kidneys to absorb more water, which reduces urine production. It also helps with blood clotting. The medication starts working within 1 hour of consumption.
Desmopressin is usually taken as a tablet two to three times a day for diabetes insipidus or once at bedtime for bedwetting. For children 6 years and older, the starting dose is 0.2 mg at bedtime, which may be increased to 0.6 mg if needed.
Common side effects of Desmopressin include headaches, nausea, and stomach pain. Serious effects like low sodium levels leading to seizures or confusion can occur if fluid intake isn't limited. Always seek medical help for severe reactions.
People with low sodium levels, severe kidney problems, or heart conditions should avoid Desmopressin. It's also unsuitable for those with a history of fluid retention issues. Elderly patients may be more prone to low sodium levels and need close monitoring, especially if taking other medications.
Indications and Purpose
What is Desmopressin used for?
It is used for central diabetes insipidus, bedwetting (nocturnal enuresis), and certain bleeding disorders like hemophilia A or von Willebrand’s disease.
How does Desmopressin work?
Desmopressin mimics the antidiuretic hormone (ADH), signaling the kidneys to absorb water, thereby reducing urine production. It also helps with blood clotting.
Is Desmopressin effective?
Yes, desmopressin is effective for controlling urine output and managing bleeding disorders when used as prescribed, as proven in studies.
How does one know if Desmopressin is working?
Desmopressin begins to work within 1 hour, reducing excessive urine production or improving clotting.
Directions for Use
What is the usual dose of Desmopressin?
The optimal daily dose range of melatonin for adults is between 0.1 mg and 0.8 mg, divided into doses. For children 6 years and older, the initial dose is 0.2 mg at bedtime, which can be increased up to 0.6 mg as needed. Dosage adjustments are important to ensure an adequate response to the medication and should be individualized based on the patient's response.
How do I take Desmopressin?
Take desmopressin exactly as prescribed, with or without food. Drink only the advised amount of water, as too much fluid may lead to low sodium levels.
For how long do I take Desmopressin?
The treatment duration depends on the condition. It may range from short-term (e.g., for bedwetting) to long-term use (e.g., for diabetes insipidus).
How long does it take for Desmopressin to start working?
**What is the starting dose of desmopressin for children 6 years and older?** The starting dose of desmopressin for children 6 years and older is 0.2 mg at bedtime. This dose may be increased to 0.6 mg at bedtime if needed. **What is central diabetes insipidus?** Central diabetes insipidus is a condition in which the body does not produce enough of the hormone vasopressin. Vasopressin helps the kidneys to retain water. In people with central diabetes insipidus, the kidneys cannot retain water properly, which can lead to dehydration. **What is primary nocturnal enuresis?** Primary nocturnal enuresis is a condition in which children wet the bed at night. This condition is usually caused by a delay in the development of the bladder control mechanisms.
How should I store Desmopressin?
Store at room temperature, away from moisture and direct light. Keep it out of reach of children.
Warnings and Precautions
Who should avoid taking Desmopressin?
People with low sodium levels, severe kidney problems, or heart conditions should avoid desmopressin. It’s unsuitable for those with a history of fluid retention issues.
Can I take Desmopressin with other prescription drugs?
Desmopressin interacts with NSAIDs, diuretics, and antidepressants, increasing the risk of low sodium levels. Share your medication list with your doctor.
Can I take Desmopressin with vitamins or supplements?
Generally safe, but avoid supplements containing sodium or excessive fluid intake. Always inform your doctor about all vitamins or supplements.
Can Desmopressin be taken safely while pregnant?
Desmopressin is generally considered safe in pregnancy when needed. Consult your doctor for risks and benefits before use.
Can Desmopressin be taken safely while breastfeeding?
It may pass into breast milk in small amounts. Consult your doctor to assess the benefits and risks for your baby.
Is Desmopressin safe for the elderly?
Elderly patients may be more prone to low sodium levels. Close monitoring is required, especially if taking other medications.
Is it safe to exercise while taking Desmopressin?
Yes, but avoid excessive fluid intake during intense exercise. Monitor hydration levels and avoid overexertion.
Is it safe to drink alcohol while taking Desmopressin?
Alcohol can increase the risk of side effects like drowsiness and confusion. It’s best to avoid alcohol during treatment.
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