Cyclophosphamide
Idiopathic Thrombocytopenic Purpura, BCR-ABL Positive Chronic Myelogenous Leukemia ... show more
.svg)
DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
YES
Teratogenicity
Unlisted
Pharmaceutical Class
Alkylating Drug
Cyclophosphamide
Know More About This Medicine -
Click HereSummary
Cyclophosphamide is primarily used to treat various cancers like lymphoma, leukemia, breast cancer, and ovarian cancer. It is also used to manage autoimmune disorders such as lupus, rheumatoid arthritis, and certain types of vasculitis.
Cyclophosphamide works by interfering with the DNA of cancer cells, preventing them from growing and dividing. This is particularly effective against rapidly growing cells like cancer cells.
The dosage for Cyclophosphamide varies depending on the condition. For cancers, it can range from 50 mg to 200 mg per day, while for autoimmune diseases, it may vary from 1 to 2 mg/kg body weight daily. It is typically administered by intravenous injection in a healthcare setting, but it can also be taken orally in tablet form.
Common side effects of Cyclophosphamide include nausea, vomiting, hair loss, fatigue, and lowered immune function. Serious side effects can include heart damage, bladder issues, and increased risk of infections.
Cyclophosphamide should be avoided by those with a history of severe allergic reactions to it, active infections, certain heart conditions, and pregnant women. It's not safe to take while breastfeeding. It can interact with several medications and supplements, so it's important to inform your doctor about all medicines you're taking.
Indications and Purpose
What is Cyclophosphamide used for?
Cyclophosphamide is primarily used for treating cancers such as lymphoma, leukemia, breast cancer, and ovarian cancer. It also treats autoimmune diseases, including lupus, rheumatoid arthritis, and certain types of vasculitis by suppressing the immune system.
How does Cyclophosphamide work?
Cyclophosphamide works by alkylating the DNA inside cells, preventing them from dividing and reproducing. This action is particularly effective against rapidly growing cells, including cancer cells, thereby inhibiting their ability to multiply.
Is Cyclophosphamide effective?
Cyclophosphamide is considered highly effective in the treatment of various cancers and autoimmune diseases, especially when used in combination with other chemotherapy or immunosuppressive agents. Its effectiveness is well-established in clinical studies and patient experiences.
How does one know if Cyclophosphamide is working?
Doctors monitor the effectiveness of Cyclophosphamide through regular blood tests, imaging scans, and evaluating the symptoms. A reduction in tumor size or improvement in blood counts indicates the drug is working.
Directions for Use
What is the usual dose of Cyclophosphamide?
The dose varies depending on the condition being treated and the individual's response to the drug. For cancers, the dose can range from 50 mg to 200 mg per day, while for autoimmune diseases, it may vary from 1 to 2 mg/kg body weight daily, as determined by the doctor.
How do I take Cyclophosphamide?
Cyclophosphamide is typically administered by intravenous injection (IV) in a healthcare setting. In some cases, it can be taken orally in tablet form. It is often given in cycles based on the treatment plan provided by the doctor. Ensure to take the drug as directed.
For how long do I take Cyclophosphamide?
The length of treatment with Cyclophosphamide depends on the type of cancer or disease being treated, and the patient's response to the therapy. Typically, cancer treatments last several months, with cycles of the drug, while autoimmune treatments may last longer, up to a few years.
How long does it take for Cyclophosphamide to start working?
The response time varies depending on the condition. For cancers, you may start noticing improvements in weeks to months, while autoimmune conditions may take several weeks to show noticeable results. Consistent monitoring by the doctor is important during this period.
How should I store Cyclophosphamide?
Store Cyclophosphamide at room temperature, away from moisture, heat, and direct sunlight. If it’s in liquid form, refrigerate according to the manufacturer’s instructions. Keep it out of reach of children and safely dispose of any unused medicine.
Warnings and Precautions
Who should avoid taking Cyclophosphamide?
Cyclophosphamide should be avoided by individuals who have a history of severe allergic reactions to it, active infections, or certain heart conditions. Pregnant women and those with a history of bladder or bone marrow problems should consult their doctor before starting treatment.
Can I take Cyclophosphamide with other prescription drugs?
Cyclophosphamide can interact with several medications, including corticosteroids, blood thinners, and certain antibiotics. These interactions can either increase side effects or reduce the effectiveness of treatment, so make sure your healthcare provider is aware of all medicines you are taking.
Can I take Cyclophosphamide with vitamins or supplements?
Some supplements, especially antioxidants like Vitamin E, may interfere with the chemotherapy action. It’s essential to inform your doctor about any vitamins or supplements you’re taking to avoid any possible interactions or unwanted effects.
Can Cyclophosphamide be taken safely while pregnant?
Cyclophosphamide is not recommended during pregnancy due to its potential to harm the developing fetus, causing birth defects or miscarriage. Women who may become pregnant must use effective contraception while undergoing treatment.
Can Cyclophosphamide be taken safely while breastfeeding?
Cyclophosphamide is not considered safe to take while breastfeeding, as it can pass into breast milk and harm the infant. It is advised to avoid breastfeeding during treatment and for a period afterward.
Is Cyclophosphamide safe for the elderly?
Elderly patients may experience more pronounced side effects like lowered immune function or kidney issues. Special care is needed, with frequent monitoring of kidney and heart function during treatment to ensure safety and effectiveness.
Is it safe to exercise while taking Cyclophosphamide?
Moderate exercise is generally safe but should be approached with caution, especially if experiencing fatigue or other side effects. Your doctor can provide personalized advice about exercise based on your condition and overall health.
Is it safe to drink alcohol while taking Cyclophosphamide?
It’s advisable to limit or avoid alcohol while on Cyclophosphamide as it can increase side effects such as liver toxicity, dehydration, or exacerbate nausea and vomiting. Always consult your doctor regarding alcohol consumption during treatment.
Forms / Brands
