Chlordiazepoxide
Anxiety Disorders, Alcohol Withdrawal Delirium
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DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
NO
Teratogenicity
Unlisted
Pharmaceutical Class
Benzodiazepine
Chlordiazepoxide
Know More About This Medicine -
Click HereSummary
Chlordiazepoxide is used to treat anxiety disorders, withdrawal symptoms from alcohol, and anxiety before surgery.
Chlordiazepoxide works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in your brain. This neurotransmitter reduces nerve cell activity, leading to calming effects, reducing anxiety, inducing sedation, and reducing muscle spasms.
Chlordiazepoxide is taken orally. The starting dose for adults is 50-100 mg per day, which can be adjusted up to 300 mg per day if needed. Once symptoms are under control, the dose is reduced to the lowest effective amount. For elderly or debilitated patients, the starting dose is 10 mg or less per day.
Common side effects include feeling sleepy, having trouble moving, and confusion. In rare cases, it can cause serious problems like passing out, seizures, or even death.
Never take Chlordiazepoxide with opioids as it can lead to serious side effects like slowed breathing, coma, or even death. This medication can be addictive, and stopping suddenly can cause serious withdrawal symptoms which can be life-threatening.
Indications and Purpose
What is Chlordiazepoxide used for?
Chlordiazepoxide is indicated for the management of anxiety disorders, short-term relief of anxiety symptoms, treatment of withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
How does Chlordiazepoxide work?
Chlordiazepoxide works by enhancing the effects of the neurotransmitter GABA in the brain. This action helps to calm the nervous system, reducing anxiety and producing a sedative effect.
Is Chlordiazepoxide effective?
Chlordiazepoxide is a benzodiazepine with proven effectiveness in relieving anxiety, as demonstrated by extensive clinical evidence. It is considered a safer psychopharmacologic compound for managing anxiety disorders and related conditions.
How does one know if Chlordiazepoxide is working?
The benefit of Chlordiazepoxide is evaluated by assessing the reduction in anxiety symptoms and improvement in the patient's overall condition. Regular follow-ups with a healthcare provider are necessary to monitor effectiveness and adjust the dosage as needed.
Directions for Use
What is the usual dose of Chlordiazepoxide?
For adults, the usual dose of Chlordiazepoxide is 5 mg or 10 mg, taken 3 or 4 times daily. For children, the dosage should be initiated with the lowest dose and increased as required. However, use in children under 6 years of age is not recommended.
How do I take Chlordiazepoxide?
Chlordiazepoxide can be taken with or without food. There are no specific food restrictions, but it is important to avoid alcohol as it can increase the sedative effects of the medication. Always follow your healthcare provider's instructions regarding dosage and administration.
For how long do I take Chlordiazepoxide?
Chlordiazepoxide is typically used for short-term relief of anxiety symptoms. The effectiveness of long-term use, beyond 4 months, has not been systematically assessed. It is important to periodically reassess the need for continued treatment.
How long does it take for Chlordiazepoxide to start working?
Chlordiazepoxide takes several hours to reach peak blood levels, and its effects can be felt within this time frame. However, the exact onset of action may vary depending on individual factors such as metabolism and dosage.
How should I store Chlordiazepoxide?
Store Chlordiazepoxide at room temperature between 68°F to 77°F (20°C to 25°C) in a dry place. Keep it in a tightly closed, light-resistant container and out of the reach of children. Follow any additional storage instructions provided by your pharmacist.
Warnings and Precautions
Who should avoid taking Chlordiazepoxide?
Chlordiazepoxide should not be used with opioids due to risks of sedation, respiratory depression, coma, and death. It carries risks of abuse, misuse, addiction, and physical dependence. Avoid abrupt discontinuation to prevent withdrawal reactions. It is contraindicated in patients with hypersensitivity to the drug.
Can I take Chlordiazepoxide with other prescription drugs?
Chlordiazepoxide should not be used with opioids due to increased risk of respiratory depression. Caution is advised when used with other CNS depressants, MAO inhibitors, and phenothiazines. Always inform your healthcare provider about all medications you are taking.
Can I take Chlordiazepoxide with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Chlordiazepoxide be taken safely while pregnant?
Chlordiazepoxide use during pregnancy can cause sedation and withdrawal symptoms in newborns. There is a pregnancy registry to monitor outcomes. Pregnant women should consult their healthcare provider and consider alternatives due to potential risks.
Can Chlordiazepoxide be taken safely while breastfeeding?
Breastfeeding is not recommended during treatment with Chlordiazepoxide due to the potential for serious adverse reactions in infants, including sedation and withdrawal symptoms. Consult your healthcare provider for alternative treatments.
Is Chlordiazepoxide safe for the elderly?
For elderly patients, it is recommended to use the smallest effective dose of Chlordiazepoxide to avoid ataxia or oversedation. Start with 10 mg or less per day and increase gradually as needed. Close monitoring is essential to prevent adverse effects.
Is it safe to exercise while taking Chlordiazepoxide?
Chlordiazepoxide may impair physical abilities due to its sedative effects, which can cause drowsiness and ataxia. This may limit your ability to exercise safely. It is advisable to avoid strenuous activities until you understand how the medication affects you.
Is it safe to drink alcohol while taking Chlordiazepoxide?
Drinking alcohol while taking Chlordiazepoxide can be dangerous. Alcohol can increase the sedative effects of Chlordiazepoxide, leading to severe drowsiness, respiratory depression, coma, or even death. It is advised to avoid alcohol consumption while on this medication.
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