Candesartan
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DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
NO
Teratogenicity
Definite
Pharmaceutical Class
Angiotensin 2 Receptor Blocker
Candesartan
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Click HereSummary
Candesartan is commonly used to treat high blood pressure and heart failure. It helps to lower blood pressure and reduce the risk of heart attacks and strokes. In heart failure, it improves symptoms and reduces hospitalizations.
Candesartan works by blocking the action of a substance in your body called angiotensin II, which causes blood vessels to tighten and narrow. By blocking this action, Candesartan helps to relax and widen your blood vessels, which lowers your blood pressure and improves blood flow.
For adults, the usual starting dose of Candesartan for high blood pressure is 16 mg once daily, which can be adjusted based on response. For children aged 1 to 17 years, the dose varies by weight. Always follow your doctor's specific dosing instructions.
Common side effects of Candesartan include headache, dizziness, and back pain. Serious side effects, though rare, include swelling of the face or throat, difficulty breathing, and decreased urination. If any serious side effects occur, seek medical attention immediately.
Candesartan should not be used during pregnancy and by those with known hypersensitivity to the drug. Caution is advised for patients with kidney or liver problems, and those taking potassium supplements due to the risk of high potassium levels in the blood.
Indications and Purpose
What is Candesartan used for?
Candesartan is indicated for the treatment of high blood pressure (hypertension) and heart failure. It is used to lower blood pressure, reducing the risk of cardiovascular events such as heart attacks and strokes. In heart failure, it helps improve symptoms and reduce hospitalizations by making it easier for the heart to pump blood.
How does Candesartan work?
Candesartan works by blocking the action of angiotensin II, a substance in the body that causes blood vessels to tighten and narrow. By inhibiting this action, Candesartan helps to relax and widen blood vessels, which lowers blood pressure and improves blood flow. This mechanism also reduces the workload on the heart, making it easier for the heart to pump blood.
Is Candesartan effective?
Candesartan has been shown to effectively lower blood pressure and reduce the risk of cardiovascular events such as stroke and heart attack in patients with hypertension. Clinical trials have demonstrated its efficacy in improving heart failure symptoms and reducing hospitalizations. Its effectiveness is attributed to its ability to block angiotensin II receptors, leading to vasodilation and reduced blood pressure.
How does one know if Candesartan is working?
The benefit of Candesartan is evaluated through regular monitoring of blood pressure and assessment of heart failure symptoms. Patients should have their blood pressure checked regularly to ensure the medication is effectively controlling it. Additionally, any changes in symptoms or side effects should be reported to the doctor, who may adjust the dosage or treatment plan as needed.
Directions for Use
What is the usual dose of Candesartan?
For adults, the usual starting dose of Candesartan for hypertension is 16 mg once daily, which can be adjusted between 8 mg to 32 mg per day based on response. For children aged 1 to <17 years, the dose varies by weight: those under 50 kg typically start at 4 to 8 mg, while those over 50 kg may start at 8 to 16 mg. Always follow your doctor's specific dosing instructions.
How do I take Candesartan?
Candesartan can be taken with or without food, usually once or twice a day as prescribed by your doctor. It is important to take it at the same time each day to maintain consistent blood levels. Avoid using salt substitutes containing potassium without consulting your doctor, as this can increase the risk of hyperkalemia. Follow any dietary recommendations provided by your healthcare provider.
For how long do I take Candesartan?
Candesartan is typically used as a long-term treatment for managing high blood pressure and heart failure. The duration of use is determined by the treating physician based on the patient's condition and response to the medication. It is important to continue taking Candesartan even if you feel well, unless advised otherwise by your doctor.
How long does it take for Candesartan to start working?
Candesartan may start to lower blood pressure within the first two weeks of treatment, but it can take up to four to six weeks to notice the full benefit. It is important to continue taking the medication as prescribed, even if you feel well, and to attend regular check-ups to monitor your blood pressure.
How should I store Candesartan?
Candesartan should be stored at room temperature, away from excess heat and moisture. It should be kept in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom. Unused medication should be disposed of properly, preferably through a medicine take-back program, to prevent accidental ingestion by children or pets.
Warnings and Precautions
Who should avoid taking Candesartan?
Candesartan is contraindicated in pregnancy due to the risk of fetal harm. It should not be used in patients with known hypersensitivity to the drug or its components. Caution is advised in patients with renal or hepatic impairment, and those taking potassium supplements or potassium-sparing diuretics due to the risk of hyperkalemia. Regular monitoring of blood pressure and kidney function is recommended.
Can I take Candesartan with other prescription drugs?
Candesartan may interact with other medications that affect blood pressure, such as diuretics, leading to an increased risk of hypotension. It can also interact with potassium supplements or potassium-sparing diuretics, increasing the risk of hyperkalemia. Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce its antihypertensive effect and worsen renal function. Always inform your doctor of all medications you are taking.
Can I take Candesartan with vitamins or supplements?
Candesartan can interact with potassium supplements and potassium-containing salt substitutes, increasing the risk of hyperkalemia. It is important to inform your doctor of any vitamins or supplements you are taking, as they may need to adjust your treatment plan to avoid potential interactions. Regular monitoring of potassium levels may be necessary.
Can Candesartan be taken safely while pregnant?
Candesartan is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm, including kidney damage and death. Studies have shown that drugs affecting the renin-angiotensin system can cause fetal toxicity. Women of childbearing age should use effective contraception while taking Candesartan and discontinue use immediately if pregnancy is detected.
Can Candesartan be taken safely while breastfeeding?
It is not known whether Candesartan is excreted in human breast milk, but it is present in the milk of lactating animals. Due to the potential for adverse effects on the nursing infant, a decision should be made to either discontinue breastfeeding or discontinue the medication, considering the importance of the drug to the mother. Consult your doctor for personalized advice.
Is Candesartan safe for the elderly?
Elderly patients taking Candesartan should be monitored closely, as they may be more sensitive to its effects, particularly the risk of hypotension (low blood pressure) and renal function changes. Dose adjustments may be necessary based on the individual's response and tolerance. Regular monitoring of blood pressure and kidney function is recommended to ensure safe use.
Is it safe to exercise while taking Candesartan?
Candesartan does not typically limit the ability to exercise. However, because it can cause dizziness or lightheadedness, especially when starting the medication or adjusting the dose, it is important to be cautious when engaging in physical activities. If you experience any symptoms that affect your ability to exercise, consult your doctor for advice.
Is it safe to drink alcohol while taking Candesartan?
Drinking alcohol while taking Candesartan can enhance the blood pressure-lowering effect of the medication, which may lead to dizziness or fainting. It is generally advised to limit alcohol consumption while on this medication to avoid these potential side effects. Always consult with your doctor for personalized advice.