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Brivaracetam

Seizures

DRUG STATUS

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Approvals

US(FDA), UK(BNF)

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Essential Medicine

NO

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Teratogenicity

Unlisted

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Pharmaceutical Class

N/A

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Drug Ingredient

Brivaracetam

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Summary

  • Brivaracetam is an anticonvulsant or anti-seizure medication. It is primarily used to treat partial-onset seizures in individuals who have epilepsy.

  • Brivaracetam works by modulating a protein in the brain known as synaptic vesicle protein 2A (SV2A). This action is thought to reduce abnormal electrical activity in the brain, thus helping to control seizures.

  • Brivaracetam can be taken orally as tablets, liquid, or via injection. Adults typically take 100mg a day, but the dosage can range from 50mg to 200mg. For children, the dosage depends on their weight.

  • Common side effects of Brivaracetam include drowsiness, dizziness, and mood changes. It can also cause nausea and vomiting. In rare cases, it may lead to serious problems like suicidal thoughts and changes in behavior.

  • Brivaracetam may cause cognitive side effects like difficulty concentrating or confusion. If you feel depressed, your mood changes, or you have thoughts of suicide, tell your doctor right away. It's important not to stop taking it suddenly and to avoid driving or operating heavy machinery until you know how it affects you.

Indications and Purpose

What is Brivaracetam used for?

Briviact is a medicine that helps control a type of seizure called a partial-onset seizure. It can be used for people of all ages, starting from one month old. Doctors don't know if it's safe or works well for babies younger than one month.

How does Brivaracetam work?

Brivaracetam is a medicine that's easily and fully absorbed when you take it by mouth. Your body processes it in a predictable way at normal doses. It's broken down in the body and leaves your system mostly through your urine. It takes about 9 hours for half of the medicine to leave your body.

Is Brivaracetam effective?

Brivaracetam helped reduce seizures in some people. Three big studies showed that, compared to a sugar pill, it lowered the number of seizures by 9.5% to 25.7%. Higher doses generally led to bigger reductions.

How does one know if Brivaracetam is working?

Studies compared brivaracetam to a sugar pill (placebo) to see if it helped reduce seizures. The studies looked at how many seizures people had each week and each month. Results showed that brivaracetam lowered the number of seizures in some people compared to those who took the placebo. For example, one dose reduced seizures by 17% over a week, and another dose reduced them by 26% over a month. Scientists used statistics to confirm these weren't just random differences.

Directions for Use

What is the usual dose of Brivaracetam?

Adults usually take 100mg a day, but it can be as low as 50mg or as high as 200mg. For kids, the amount depends on their weight. Heavier kids (50kg and up) get the same dose as adults. Lighter kids get a smaller amount based on their weight in kilograms (kg). The instructions give a range for each weight group, so a doctor will decide the exact amount.

How do I take Brivaracetam?

Brivaracetam is taken orally as tablets, liquid, or via injection. It can be taken with or without food. If prescribed tablets or liquid, take it at the same time each day to maintain consistent levels in your body.

For how long do I take Brivaracetam?

Brivaracetam is usually taken as a long-term treatment for epilepsy. The duration of therapy is determined by your healthcare provider based on your condition and seizure control.

How long does it take for Brivaracetam to start working?

Brivaracetam is quickly and almost completely absorbed into your body when you take it by mouth. It usually reaches its peak level in your blood within an hour, but a fatty meal can delay this by three hours. Doctors don't usually start you on a low dose and gradually increase it; you can start taking a normal dose right away.

How should I store Brivaracetam?

Keep Briviact pills at room temperature, not too hot or cold. Don't freeze the liquid or injection. Use the liquid within 5 months of opening. The injection is for one use only.

Warnings and Precautions

Who should avoid taking Brivaracetam?

Brivaracetam is a medicine that can help some people, but it has some risks. A very small number of people who take it might have thoughts of harming themselves. It can also make you sleepy, dizzy, unsteady on your feet, or change your behavior (make you angry, anxious, or irritable). Because of these risks, it's important to tell your doctor about any mental health problems or substance abuse you have before taking it. Don't stop taking it suddenly, and don't drive or operate heavy machinery until you know how it affects you. If you feel depressed, your mood changes, or you have thoughts of suicide, tell your doctor right away.

Can I take Brivaracetam with other prescription drugs?

Brivaracetam may interact with other medications, including:

  • Other antiepileptic drugs (e.g., carbamazepine, phenytoin)
  • Sedatives or CNS depressants
  • Rifampin (an antibiotic)Always inform your doctor about all medications you are taking.

Can I take Brivaracetam with vitamins or supplements?

Brivaracetam generally does not interact with most vitamins or supplements. However, consult your doctor to ensure no specific supplements interfere with its effectiveness.

Can Brivaracetam be taken safely while pregnant?

Limited data exist on Brivaracetam in pregnancy. It should only be used if the potential benefits outweigh the risks. Discuss with your doctor if you're pregnant or planning to become pregnant.

Can Brivaracetam be taken safely while breastfeeding?

Brivaracetam, a medicine some mothers take, passes into breast milk. It's important to talk to your doctor about breastfeeding. They can help you weigh the good things about breastfeeding for your baby against any possible risks from the medicine or your health problem that needs treatment.

Is Brivaracetam safe for the elderly?

Older adults (65 and up) often need lower doses of medicine. This is because their livers, kidneys, and hearts might not work as well as younger people's, and they may have other health problems or be taking other medications. Starting with a small dose helps prevent problems.

Is it safe to exercise while taking Brivaracetam?

Yes, you can exercise while taking Brivaracetam, provided you feel well and are not experiencing significant side effects such as dizziness or fatigue. Always listen to your body and stay hydrated.

Is it safe to drink alcohol while taking Brivaracetam?

Mixing the seizure medicine brivaracetam with alcohol makes it harder to think clearly, pay attention, and remember things. It slows down your eye movements and makes you less alert. You'll also be more unsteady on your feet and slower to react. Basically, it makes you less coordinated and more forgetful.