Alfuzosin
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DRUG STATUS
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Alpha-Adrenergic Blocker
Controlled Drug Substance
No
Alfuzosin
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Click HereSummary
Alfuzosin is a medication used to treat the symptoms of an enlarged prostate in adult men. It is not intended for use by women or children.
Alfuzosin works by relaxing the muscles around the bladder and prostate, which helps urine flow more easily. It does not typically affect weight, appetite, or eating behaviors.
Alfuzosin is typically administered as extended-release tablets taken with food and the same meal each day. The tablets should not be crushed or chewed as they are designed to release the medication slowly over time.
Common side effects of Alfuzosin include dizziness, headaches, and fatigue. Other side effects include upper respiratory tract infection, abdominal pain, and nausea. Serious side effects include a sudden drop in blood pressure and a painful, long-lasting erection known as priapism.
Alfuzosin can lower blood pressure, especially when first taken, which could cause dizziness or fainting. It should not be taken if you have liver problems, are taking certain antifungal or anti-HIV medicines, or are allergic to Alfuzosin. It is important to avoid driving or operating machinery until you know how Alfuzosin affects you.
Indications and Purpose
What is Alfuzosin used for?
Alfuzosin is indicated for the treatment of symptoms associated with benign prostatic hyperplasia (BPH) in men. It helps alleviate urinary difficulties such as hesitation, dribbling, weak stream, and incomplete bladder emptying.
How does Alfuzosin work?
Alfuzosin is an alpha blocker that selectively targets alpha-1 adrenergic receptors in the prostate and bladder. By blocking these receptors, it relaxes the smooth muscles in these areas, improving urine flow and reducing symptoms of benign prostatic hyperplasia (BPH).
Is Alfuzosin effective?
Clinical trials have shown that Alfuzosin significantly improves urinary flow rates and reduces symptoms of benign prostatic hyperplasia (BPH). Patients reported a reduction in symptom severity and an increase in peak urinary flow rate, demonstrating the medication's effectiveness.
How does one know if Alfuzosin is working?
The benefit of Alfuzosin is evaluated by monitoring the improvement in urinary symptoms associated with benign prostatic hyperplasia (BPH). Regular follow-up appointments with your doctor will help assess the effectiveness of the treatment and make any necessary adjustments.
Directions for Use
What is the usual dose of Alfuzosin?
The usual daily dose for adults is one 10 mg extended-release tablet taken once daily. Alfuzosin is not indicated for use in children.
How do I take Alfuzosin?
Take Alfuzosin as an extended-release tablet once daily, immediately after a meal. Do not take it on an empty stomach. Swallow the tablet whole without crushing or chewing. Discuss with your doctor about consuming grapefruit or grapefruit juice while on this medication.
For how long do I take Alfuzosin?
Alfuzosin is typically used as a long-term treatment for symptoms of an enlarged prostate. It is important to continue taking it even if you feel well, as it controls symptoms but does not cure the condition.
How long does it take for Alfuzosin to start working?
Alfuzosin may start to improve symptoms within a few days, but it can take up to a few weeks to experience the full benefits. Continue taking the medication as prescribed, even if you feel well.
How should I store Alfuzosin?
Store Alfuzosin in its original container, tightly closed, at room temperature away from light, excess heat, and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program.
Warnings and Precautions
Who should avoid taking Alfuzosin?
Alfuzosin should not be used in patients with moderate or severe liver impairment or those taking potent CYP3A4 inhibitors. It may cause dizziness and fainting, especially when standing up quickly. Patients should be cautious when driving or operating machinery. Women, especially those who are pregnant or breastfeeding, should not take Alfuzosin.
Can I take Alfuzosin with other prescription drugs?
Alfuzosin should not be taken with potent CYP3A4 inhibitors like ketoconazole, itraconazole, or ritonavir, as these can increase Alfuzosin blood levels. Caution is advised when used with other alpha-blockers, antihypertensive medications, and PDE5 inhibitors due to the risk of hypotension.
Can I take Alfuzosin with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Alfuzosin be taken safely while pregnant?
Alfuzosin is not indicated for use in women, especially during pregnancy. There is no adequate data on the developmental risk associated with its use in pregnant women. Consult a healthcare provider for personalized advice.
Can Alfuzosin be taken safely while breastfeeding?
Alfuzosin is not indicated for use in women, including those who are breastfeeding. There is no data on its presence in human milk or its effects on the breastfed child. Consult a healthcare provider for personalized advice.
Is Alfuzosin safe for the elderly?
Elderly patients may be more sensitive to the effects of Alfuzosin, particularly the risk of dizziness and fainting. It is important for elderly patients to be cautious when standing up quickly and to avoid activities that require full alertness until they know how the medication affects them.
Is it safe to exercise while taking Alfuzosin?
Alfuzosin may cause dizziness or lightheadedness, especially when you first start taking it. This could potentially affect your ability to exercise safely. If you experience these symptoms, it is advisable to avoid strenuous activities until you know how the medication affects you.
Is it safe to drink alcohol while taking Alfuzosin?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
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