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Acarbose

Type 2 Diabetes Mellitus

DRUG STATUS

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Approvals

US(FDA), UK(BNF)

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Essential Medicine

NO

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Teratogenicity

N/A

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Pharmaceutical Class

Alpha-Glucosidase Inhibitor

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Acarbose

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Summary

  • Acarbose is a medication used to manage blood sugar levels in people with type 2 diabetes.

  • Acarbose works by blocking enzymes in your intestines that break down carbohydrates into simple sugars. This slows down the breakdown of carbohydrates, helping to prevent spikes in your blood sugar levels after meals.

  • Acarbose is taken by mouth with the first bite of each main meal. The starting dose is usually 25 mg three times a day, but can be increased to 50 mg three times a day if needed. The maximum dose depends on your weight.

  • The most common side effects of Acarbose are digestive issues like gas, diarrhea, and stomach discomfort. These usually improve over time. Serious but rare side effects include liver problems, skin reactions, swelling, intestinal blockages, and low platelet count.

  • Acarbose can cause hypoglycemia, especially if taken with other diabetes medications. It's also not well understood how Acarbose affects fertility or its safety during pregnancy and breastfeeding. It's important to discuss these potential risks with your healthcare provider. Certain medications and supplements, like amoxicillin, corticosteroids, and vitamin C, can interact with Acarbose.

Indications and Purpose

What is Acarbose used for?

Acarbose help people with type 2 diabetes control their blood sugar levels. They work by slowing down the breakdown of carbohydrates in food, which helps keep blood sugar levels from getting too high after meals. Acarbose should be used along with a healthy diet and exercise plan.

How does Acarbose work?

Acarbose is a medication that helps manage blood sugar levels after eating. It works by blocking enzymes in the intestines that break down carbohydrates into simple sugars. By slowing down the breakdown of carbohydrates, acarbose helps prevent spikes in blood sugar levels after meals. Acarbose does not affect the enzyme that breaks down lactose, so it does not cause lactose intolerance.

Is Acarbose effective?

Acarbose has been shown to be effective in improving glycemic control in people with type 2 diabetes, and in reducing the risk of microvascular complications.


How does one know if Acarbose is working?

The benefit of Acarbose is monitored by checking blood glucose levels and HbA1c levels, and adjusting the dosage as needed.

Directions for Use

How do I take Acarbose?

Acarbose should be taken with meals that contain carbohydrates, with the first bite of food, and patients should follow a healthy diet and avoid high-carbohydrate foods.


For how long do I take Acarbose?

Acarbose is typically taken long-term to manage type 2 diabetes, but the exact duration depends on your condition and your doctor's advice. Always follow your healthcare provider's instructions.

How long does it take for Acarbose to start working?

Acarbose starts working as soon as it is taken, and its effects can be observed within 1-2 hours after a meal. However, the full effects of the medication may not be seen for several weeks, as it takes time for the body to adjust to the new medication.


 

How should I store Acarbose?

Acarbose should be stored at room temperature in a tightly closed container, protected from moisture, heat, and light. It should be used before the expiration date and disposed of properly.


Warnings and Precautions

Who should avoid taking Acarbose?

Hypoglycemia: Acarbose can cause hypoglycemia (low blood glucose levels) in some people, especially if taken with other diabetes medications. Patients should monitor their blood glucose levels closely and report any signs of hypoglycemia to their healthcare provider.

Digestive issues: Acarbose can cause digestive issues such as bloating, flatulence, and diarrhea, especially in the first few weeks of treatment. Patients should report any digestive symptoms to their healthcare provider.


Can I take Acarbose with other prescription drugs?

Antibiotics: Some antibiotics, such as amoxicillin, can increase the risk of hypoglycemia when taken with Acarbose.

Corticosteroids: Corticosteroids, such as prednisone, can increase blood glucose levels and reduce the effectiveness of Acarbose.

Insulin and sulfonylureas: Acarbose can increase the risk of hypoglycemia when taken with insulin or sulfonylureas, such as glipizide and glyburide.


Can I take Acarbose with vitamins or supplements?

Vitamin C: Vitamin C can decrease the effectiveness of Acarbose, as it can increase the absorption of carbohydrates in the digestive tract.

Chromium: Chromium can increase the effectiveness of Acarbose, which can increase the risk of hypoglycemia.

St. John's Wort: St. John's Wort can decrease the effectiveness of Acarbose, as it can interfere with the metabolism of the medication.


Can Acarbose be taken safely while pregnant?

Acarbose is a Pregnancy Category B drug, but there is limited information available on its safety during pregnancy, and more research is needed.


Can Acarbose be taken safely while breastfeeding?

The safety of Acarbose during breastfeeding is unknown, and breastfeeding mothers should avoid taking the medication unless the potential benefits outweigh the potential risks.


Is Acarbose safe for the elderly?

Acarbose can be used in the elderly, but caution is needed due to possible side effects and changes in kidney or liver function. Always follow your doctor’s guidance.