Voclosporin
Lupus Nephritis
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Calcineurin Inhibitor Immunosuppressant
Controlled Drug Substance
No
voclosporin
Summary
Voclosporin is used to treat lupus nephritis, which is a kidney inflammation caused by lupus, an autoimmune disease where the immune system attacks the body's own tissues.
Voclosporin works by suppressing the immune system, which helps reduce inflammation in the kidneys and improve kidney function, preventing further damage.
The usual starting dose for adults is 23.7 mg taken twice daily. It should be taken on an empty stomach, either one hour before or two hours after a meal.
Common side effects include high blood pressure and kidney problems. Some people may also experience stomach upset, such as nausea or diarrhea.
Avoid alcohol as it can increase kidney problems. It's not recommended during pregnancy or breastfeeding. Regular monitoring of kidney function and blood pressure is essential.
Indications and Purpose
How does Voclosporin work?
Voclosporin is a calcineurin inhibitor, which works by suppressing the immune system to prevent further kidney damage. Think of it like turning down the volume on an overactive immune response. This helps reduce inflammation in the kidneys and improve kidney function. It's used to treat lupus nephritis, which is kidney inflammation caused by lupus.
Is Voclosporin effective?
Voclosporin is effective in treating lupus nephritis, which is a kidney inflammation caused by lupus. Clinical studies show it helps improve kidney function and reduce protein in the urine. This medication works by suppressing the immune system to prevent further kidney damage. Always follow your doctor's instructions to achieve the best results.
What is Voclosporin?
Voclosporin is a medication used to treat lupus nephritis, which is kidney inflammation caused by lupus. It belongs to a class of drugs called calcineurin inhibitors, which work by suppressing the immune system to prevent further kidney damage. This medication helps improve kidney function and reduce protein in the urine. It's used as part of a comprehensive treatment plan for lupus nephritis.
Directions for Use
For how long do I take Voclosporin?
Voclosporin is usually a long-term medication for managing lupus nephritis, which is kidney inflammation caused by lupus. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Voclosporin treatment.
How do I dispose of Voclosporin?
If you can, bring unused Voclosporin to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Voclosporin?
Take Voclosporin exactly as your doctor prescribes. It's usually taken twice daily, in the morning and evening, on an empty stomach, at least one hour before or two hours after a meal. Do not crush or chew the capsules. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Never take two doses at once. Follow your doctor's advice on diet and fluid intake.
How long does it take for Voclosporin to start working?
Voclosporin begins working in your body shortly after you take it, but the full therapeutic effect may take several weeks to months. You'll know it's working when your kidney function improves, and protein levels in your urine decrease. How quickly the medication works can depend on your overall health and how your body responds. Take it exactly as prescribed for the best results.
How should I store Voclosporin?
Store Voclosporin at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep it out of reach of children to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Voclosporin?
The usual starting dose of Voclosporin for adults is 23.7 mg taken twice daily. Your doctor may adjust your dose based on your response and any side effects. Always follow your doctor's specific dosing instructions. The maximum recommended dose should not be exceeded. Special populations, such as the elderly, may require dose adjustments.
Warnings and Precautions
Can I take Voclosporin with other prescription drugs?
Voclosporin can interact with other medications, increasing the risk of adverse effects. For example, it may interact with drugs that affect the immune system or those that are metabolized by the liver. Always inform your doctor about all the medications you are taking to manage potential interactions and ensure your treatment remains safe and effective.
Can Voclosporin be taken safely while breastfeeding?
Voclosporin is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. If you're taking Voclosporin and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Voclosporin be taken safely while pregnant?
Voclosporin is not recommended during pregnancy due to limited evidence on its safety. Animal studies suggest potential risks, but human data is lacking. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Does Voclosporin have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Voclosporin include high blood pressure and kidney problems. Serious side effects can occur, such as increased risk of infections. If you notice any new or worsening symptoms, contact your doctor immediately. Regular monitoring by your healthcare provider can help manage these risks.
Does Voclosporin have any safety warnings?
Yes, Voclosporin has important safety warnings. It can increase the risk of kidney problems and high blood pressure. Not adhering to these warnings can lead to serious health issues. Always follow your doctor's instructions and report any unusual symptoms immediately. Regular monitoring of kidney function and blood pressure is essential while taking this medication.
Is it safe to drink alcohol while taking Voclosporin?
It's best to avoid alcohol while taking Voclosporin. Alcohol can increase the risk of kidney problems and high blood pressure, which are potential side effects of Voclosporin. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like dizziness or nausea. Talk with your doctor about alcohol use while taking Voclosporin.
Is it safe to exercise while taking Voclosporin?
You can exercise while taking Voclosporin, but keep a few things in mind. This medication can cause high blood pressure, which might affect your exercise capacity. To exercise safely, monitor your blood pressure and stay hydrated. If you notice dizziness or unusual fatigue, slow down or stop exercising and rest. Check with your doctor if you have concerns about your specific situation.
Is it safe to stop Voclosporin?
Stopping Voclosporin suddenly can cause your condition to worsen. It's usually used long-term for chronic conditions. Always talk with your doctor before stopping Voclosporin. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
Is Voclosporin addictive?
Voclosporin is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. This medication works by affecting your immune system to help manage your condition. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Voclosporin doesn't carry this risk.
Is Voclosporin safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Voclosporin, such as kidney problems and high blood pressure. Regular monitoring by a healthcare provider is important to manage these risks. Your doctor may adjust the dose based on your kidney function and overall health to ensure safe use of Voclosporin.
What are the most common side effects of Voclosporin?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Voclosporin include high blood pressure and kidney problems. These effects vary from person to person. If you notice new symptoms after starting Voclosporin, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Voclosporin?
Don't take Voclosporin if you're allergic to it or its ingredients. It's contraindicated in patients with severe kidney impairment. Caution is needed in patients with high blood pressure or those taking other medications that affect the immune system. Always consult your doctor about these concerns to ensure safe use of Voclosporin.
