Venetoclax
Lymphoid Leukemia
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
BCL-2 Inhibitor
Controlled Drug Substance
NO
Venetoclax
Summary
Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). It is often used in combination with other medications to enhance its effectiveness.
Venetoclax works by inhibiting the BCL2 protein. This protein helps cancer cells survive. By blocking this protein, Venetoclax promotes the death of cancer cells, helping to reduce the number of cancerous cells in the body.
For CLL or SLL, Venetoclax is typically started at a low dose and gradually increased over 5 weeks to a daily dose of 400 mg. For AML, the dose depends on the combination agent and is gradually increased over 3 to 4 days to a daily dose of 400 mg or 600 mg. Venetoclax should be taken once daily with a meal and water.
Common side effects of Venetoclax include decreased appetite, difficulty falling asleep, headaches, nausea, diarrhea, vomiting, constipation, weight loss, and fatigue. It may also cause dizziness or fatigue which could affect your ability to drive.
Venetoclax can interact with strong and moderate CYP3A inhibitors, increasing its levels and risk of side effects. It's contraindicated with strong CYP3A inhibitors during the initial dose ramp-up phase. Venetoclax may cause harm to an unborn baby, so women who can become pregnant should use effective contraception during treatment. It's not known if Venetoclax passes into breast milk, so breastfeeding is not recommended during treatment.
Indications and Purpose
How does one know if Venetoclax is working?
The benefit of Venetoclax is evaluated through regular medical check-ups and laboratory tests ordered by your doctor. These tests monitor your body's response to the medication, including blood counts and other relevant health indicators. Always keep all appointments with your healthcare provider to ensure the treatment is working effectively.
How does Venetoclax work?
Venetoclax works by inhibiting the BCL-2 protein, which is involved in preventing cancer cell death. By blocking this protein, Venetoclax promotes the death of cancer cells, helping to reduce the number of cancerous cells in the body. This mechanism is particularly effective in certain types of leukemia.
Is Venetoclax effective?
Venetoclax has been shown to be effective in treating chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) through clinical trials. It works by inhibiting the BCL-2 protein, which helps cancer cells survive, thereby promoting cancer cell death. Clinical studies have demonstrated its ability to improve progression-free survival and overall response rates in patients.
What is Venetoclax?
Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). It works by inhibiting the BCL-2 protein, which helps cancer cells survive, thereby promoting cancer cell death. Venetoclax is often used in combination with other medications to enhance its effectiveness.
What is Venetoclax used for?
Venetoclax is indicated for the treatment of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL), as well as acute myeloid leukemia (AML) in certain patients. It is used alone or in combination with other medications to enhance its effectiveness in treating these cancers.
Directions for Use
For how long do I take Venetoclax?
The duration of Venetoclax treatment varies based on the condition being treated. For CLL or SLL, it is often continued until disease progression or unacceptable toxicity. In combination with other drugs for AML, treatment continues until disease progression or unacceptable toxicity. Always follow your doctor's guidance on treatment duration.
How do I take Venetoclax?
Venetoclax should be taken once daily with a meal and water, at approximately the same time each day. Avoid grapefruit, Seville oranges, and starfruit, as they can interact with the medication. Always follow your doctor's instructions regarding dosage and dietary restrictions.
How long does it take for Venetoclax to start working?
The time it takes for Venetoclax to start working can vary depending on the individual and the condition being treated. Some patients may begin to see effects within a few weeks, but it may take longer for others. Regular monitoring by your doctor will help assess the effectiveness of the treatment.
How should I store Venetoclax?
Store Venetoclax in its original container at room temperature, away from excess heat and moisture. Keep it tightly closed and out of reach of children. Do not transfer the medication to a different container to ensure it remains effective and safe.
What is the usual dose of Venetoclax?
For adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), Venetoclax is typically started at a low dose and gradually increased over 5 weeks to a daily dose of 400 mg. For acute myeloid leukemia (AML), the dose depends on the combination agent and is gradually increased over 3 to 4 days to a daily dose of 400 mg or 600 mg. The safety and effectiveness of Venetoclax in children have not been established.
Warnings and Precautions
Can I take Venetoclax with other prescription drugs?
Venetoclax interacts with strong and moderate CYP3A inhibitors, which can increase its levels and risk of side effects. It is contraindicated with strong CYP3A inhibitors during the initial dose ramp-up phase. Avoid using P-gp inhibitors and certain herbal products like St. John's wort. Always inform your doctor of all medications you are taking to avoid harmful interactions.
Can I take Venetoclax with vitamins or supplements?
Venetoclax may interact with certain herbal supplements, such as St. John's wort, which can affect its effectiveness. It's important to inform your doctor about all vitamins and supplements you are taking to avoid potential interactions. Always consult your healthcare provider before starting any new supplements while on Venetoclax.
Can Venetoclax be taken safely while breastfeeding?
It is not known if Venetoclax passes into breast milk, so breastfeeding is not recommended during treatment and for 1 week after the last dose. Consult your doctor for personalized advice if you are breastfeeding or planning to breastfeed while taking Venetoclax.
Can Venetoclax be taken safely while pregnant?
Venetoclax may cause harm to an unborn baby, and it is recommended that women who can become pregnant use effective contraception during treatment and for 30 days after the last dose. There is no strong evidence from human studies, but animal studies have shown potential risks. Always consult your doctor if you are pregnant or planning to become pregnant while on Venetoclax.
Is Venetoclax safe for the elderly?
Elderly patients may require more intensive monitoring and prophylaxis to reduce the risk of tumor lysis syndrome (TLS) when starting Venetoclax. No specific dose adjustment is required solely based on age, but individual health conditions should be considered. Always follow your doctor's guidance.
Who should avoid taking Venetoclax?
Venetoclax can cause tumor lysis syndrome (TLS), a serious condition that can lead to kidney failure and other complications. It is contraindicated with strong CYP3A inhibitors during the initial dose ramp-up phase. Patients should avoid grapefruit products and certain medications that interact with Venetoclax. Always inform your doctor of all medications and supplements you are taking.