Ursodeoxycholic acid
Biliary Liver Cirrhosis, Cholelithiasis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Bile Acid
Controlled Drug Substance
NO
Ursodeoxycholic acid
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Click HereSummary
Ursodeoxycholic Acid (UDCA) is primarily used to treat liver conditions like primary biliary cholangitis and gallstones. It's also used for certain liver diseases such as nonalcoholic fatty liver disease and to prevent gallstones in those with risk factors.
UDCA works by reducing cholesterol production in the liver and improving bile flow. This helps dissolve gallstones and prevents toxic bile acids buildup. It also protects liver cells, promoting liver health.
The typical dosage for adults ranges from 10 to 15 mg per kilogram of body weight per day, divided into two to four doses. It's often taken with food to improve absorption. Capsules should be swallowed whole.
Common side effects include diarrhea, nausea, vomiting, stomach pain, constipation, and heartburn. Rarely, it can cause skin irritation, rashes, and inflammation in the lungs.
UDCA can cause severe diarrhea, nausea, and vomiting. It can also cause liver damage in patients with advanced cirrhosis or other severe liver diseases. It can increase the risk of bleeding, especially in patients with bleeding disorders or those taking blood-thinning medications.
Indications and Purpose
What is Ursodeoxycholic acid used for?
Ursodeoxycholic acid is used to treat primary biliary cholangitis, a liver disease. It helps improve liver function by reducing cholesterol production and dissolving cholesterol in bile. It may also be used for other liver-related conditions, often in combination with other treatments.
How does Ursodeoxycholic acid work?
Ursodeoxycholic acid works by reducing the production of cholesterol and dissolving cholesterol in bile. This helps improve liver function and slow the progression of liver diseases like primary biliary cholangitis. It acts like a detergent, breaking down fats and aiding in their removal from the body.
Is Ursodeoxycholic acid effective?
Ursodeoxycholic acid is primarily used to treat primary biliary cholangitis, a liver disease. It works by reducing the production of cholesterol and dissolving cholesterol in bile, which helps improve liver function. Clinical trials have shown that it can improve liver enzyme levels and slow disease progression, supporting its effectiveness.
How does one know if Ursodeoxycholic acid is working?
Ursodeoxycholic acid is used to treat primary biliary cholangitis. Its effectiveness is monitored through improvements in liver enzyme levels and symptoms. Regular blood tests and clinical evaluations by a healthcare provider help assess its effectiveness.
Directions for Use
What is the usual dose of Ursodeoxycholic acid?
The usual starting dose of Ursodeoxycholic acid for adults is typically 13-15 mg/kg/day, divided into two or three doses. The dose may be adjusted based on the individual's response and condition. The maximum recommended dose is usually around 20 mg/kg/day. For children or the elderly, dose adjustments may be necessary. Always follow your healthcare provider's instructions for dosing.
How do I take Ursodeoxycholic acid?
Take Ursodeoxycholic acid with food to improve absorption, usually two to three times a day as prescribed by your healthcare provider. There are no specific dietary restrictions, but it's important to follow your healthcare provider's instructions for optimal results.
For how long do I take Ursodeoxycholic acid?
Ursodeoxycholic acid is often used for long-term management of chronic conditions like primary biliary cholangitis. The duration of use depends on the condition being treated and the individual's response. It's crucial to follow the prescriber's instructions regarding the duration of treatment to ensure effectiveness and safety.
How long does it take for Ursodeoxycholic acid to start working?
Ursodeoxycholic acid may take several weeks to months to show its full therapeutic effect. The onset of action can vary based on individual factors and the condition being treated. It's important to follow the prescriber's instructions and attend regular check-ups to monitor progress.
How should I store Ursodeoxycholic acid?
Store Ursodeoxycholic acid at room temperature, away from moisture and light. Keep it in a secure place out of reach of children. Avoid storing it in the bathroom or near a sink to prevent exposure to moisture.
Warnings and Precautions
Who should avoid taking Ursodeoxycholic acid?
Ursodeoxycholic acid should not be used in individuals with complete biliary obstruction or known hypersensitivity to the drug. Caution is needed in patients with liver disease or gallstones. Always inform your healthcare provider about any medical conditions or allergies before starting this medication.
Can I take Ursodeoxycholic acid with other prescription drugs?
Ursodeoxycholic acid may interact with drugs like cholestyramine, colestipol, and certain antacids, which can reduce its effectiveness. These interactions may require dose adjustments or monitoring. Always inform your healthcare provider about all medications you are taking to avoid potential interactions.
Can I take Ursodeoxycholic acid with vitamins or supplements?
There are no confirmed interactions between Ursodeoxycholic acid and vitamins or supplements. However, it's important to inform your healthcare provider about all medications and supplements you are taking. This ensures safe and effective use of Ursodeoxycholic acid and helps monitor any potential nutrient depletions or adverse effects.
Is it safe to exercise while taking Ursodeoxycholic acid?
Most people tolerate Ursodeoxycholic acid well, and it should not limit your ability to exercise. There are no known symptoms caused by this medicine that would limit exercise capacity, physical strength, or endurance. However, if you experience any unusual symptoms during physical activity, consult a healthcare provider.
Is it safe to drink alcohol while taking Ursodeoxycholic acid?
Most people tolerate Ursodeoxycholic acid well, and occasional alcoholic drinks should not affect how this medicine works. There are no well-established interactions between Ursodeoxycholic acid and alcohol. However, it's always best to consume alcohol in moderation and consult with a healthcare provider for personalized advice.
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