Ursodeoxycholic acid
Biliary Liver Cirrhosis, Cholelithiasis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Bile Acid
Controlled Drug Substance
NO
Ursodeoxycholic acid
Summary
Ursodeoxycholic Acid (UDCA) is primarily used to treat liver conditions like primary biliary cholangitis and gallstones. It's also used for certain liver diseases such as nonalcoholic fatty liver disease and to prevent gallstones in those with risk factors.
UDCA works by reducing cholesterol production in the liver and improving bile flow. This helps dissolve gallstones and prevents toxic bile acids buildup. It also protects liver cells, promoting liver health.
The typical dosage for adults ranges from 10 to 15 mg per kilogram of body weight per day, divided into two to four doses. It's often taken with food to improve absorption. Capsules should be swallowed whole.
Common side effects include diarrhea, nausea, vomiting, stomach pain, constipation, and heartburn. Rarely, it can cause skin irritation, rashes, and inflammation in the lungs.
UDCA can cause severe diarrhea, nausea, and vomiting. It can also cause liver damage in patients with advanced cirrhosis or other severe liver diseases. It can increase the risk of bleeding, especially in patients with bleeding disorders or those taking blood-thinning medications.
Indications and Purpose
How does Ursodeoxycholic acid work?
Ursodeoxycholic acid works by reducing the production of cholesterol and dissolving cholesterol in bile. This helps improve liver function and slow the progression of liver diseases like primary biliary cholangitis. It acts like a detergent, breaking down fats and aiding in their removal from the body.
Is Ursodeoxycholic acid effective?
Ursodeoxycholic acid is primarily used to treat primary biliary cholangitis, a liver disease. It works by reducing the production of cholesterol and dissolving cholesterol in bile, which helps improve liver function. Clinical trials have shown that it can improve liver enzyme levels and slow disease progression, supporting its effectiveness.
What is Ursodeoxycholic acid?
Ursodeoxycholic acid is a medication used primarily to treat primary biliary cholangitis, a liver disease. It helps improve liver function by reducing cholesterol production and dissolving cholesterol in bile. It may also be used for other liver-related conditions.
Directions for Use
For how long do I take Ursodeoxycholic acid?
Ursodeoxycholic acid is often used for long-term management of chronic conditions like primary biliary cholangitis. The duration of use depends on the condition being treated and the individual's response. It's crucial to follow the prescriber's instructions regarding the duration of treatment to ensure effectiveness and safety.
How do I dispose of Ursodeoxycholic acid?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How do I take Ursodeoxycholic acid?
Take Ursodeoxycholic acid with food to improve absorption, usually two to three times a day as prescribed by your healthcare provider. There are no specific dietary restrictions, but it's important to follow your healthcare provider's instructions for optimal results.
How long does it take for Ursodeoxycholic acid to start working?
Ursodeoxycholic acid may take several weeks to months to show its full therapeutic effect. The onset of action can vary based on individual factors and the condition being treated. It's important to follow the prescriber's instructions and attend regular check-ups to monitor progress.
How should I store Ursodeoxycholic acid?
Store Ursodeoxycholic acid at room temperature, away from moisture and light. Keep it in a secure place out of reach of children. Avoid storing it in the bathroom or near a sink to prevent exposure to moisture.
What is the usual dose of Ursodeoxycholic acid?
The usual starting dose of Ursodeoxycholic acid for adults is typically 13-15 mg/kg/day, divided into two or three doses. The dose may be adjusted based on the individual's response and condition. The maximum recommended dose is usually around 20 mg/kg/day. For children or the elderly, dose adjustments may be necessary. Always follow your healthcare provider's instructions for dosing.
Warnings and Precautions
Can I take Ursodeoxycholic acid with other prescription drugs?
Ursodeoxycholic acid may interact with drugs like cholestyramine, colestipol, and certain antacids, which can reduce its effectiveness. These interactions may require dose adjustments or monitoring. Always inform your healthcare provider about all medications you are taking to avoid potential interactions.
Can Ursodeoxycholic acid be taken safely while breastfeeding?
There is limited information on whether Ursodeoxycholic acid is excreted into breast milk. The potential effects on a breastfed infant are not well-documented, and there is no clear evidence on its impact on milk supply. Due to the lack of sufficient evidence, it's important to consult a healthcare provider before taking this medicine while breastfeeding. They can help weigh the benefits and risks and provide personalized advice based on your situation.
Can Ursodeoxycholic acid be taken safely while pregnant?
The safety of Ursodeoxycholic acid during pregnancy is not well-established. There is limited information from human studies on its effects, and specific risks during different trimesters are not clearly documented. Due to the lack of sufficient evidence, it's crucial to consult a healthcare provider before using this medicine while pregnant. They can help assess the potential benefits and risks and provide guidance tailored to your individual needs.
Does Ursodeoxycholic acid have adverse effects?
Adverse effects are harmful or unintended reactions to a medication. Ursodeoxycholic acid may cause adverse effects such as diarrhea, nausea, and abdominal pain. These are generally mild and infrequent. Rarely, serious adverse effects like liver problems may occur, requiring immediate medical attention. Always report new symptoms to a healthcare provider and consult them before stopping the medication.
Does Ursodeoxycholic acid have any safety warnings?
Ursodeoxycholic acid may have safety warnings related to liver function. It's important to monitor liver enzymes regularly while taking this medication. Symptoms like jaundice, dark urine, or severe abdominal pain should be reported to a healthcare provider immediately. Always follow the prescription information and consult a healthcare provider for personalized advice.
Is it safe to drink alcohol while taking Ursodeoxycholic acid?
Most people tolerate Ursodeoxycholic acid well, and occasional alcoholic drinks should not affect how this medicine works. There are no well-established interactions between Ursodeoxycholic acid and alcohol. However, it's always best to consume alcohol in moderation and consult with a healthcare provider for personalized advice.
Is it safe to exercise while taking Ursodeoxycholic acid?
Most people tolerate Ursodeoxycholic acid well, and it should not limit your ability to exercise. There are no known symptoms caused by this medicine that would limit exercise capacity, physical strength, or endurance. However, if you experience any unusual symptoms during physical activity, consult a healthcare provider.
Is it safe to stop Ursodeoxycholic acid?
Ursodeoxycholic acid is typically used for long-term management of chronic conditions. Stopping it abruptly may lead to a return of symptoms or worsening of the condition. There are no known withdrawal symptoms, but it's important to consult a healthcare provider before stopping the medication to avoid potential complications.
Is Ursodeoxycholic acid addictive?
Ursodeoxycholic acid has no known potential for dependence or addiction. It is not habit-forming, and there are no behaviors or warning signs associated with physical or psychological dependence on this medicine.
Is Ursodeoxycholic acid safe for the elderly?
Ursodeoxycholic acid is generally considered safe for the elderly. There are no specific risks or negative outcomes more frequently observed in elderly individuals compared to younger adults. However, as with any medication, it's important to exercise caution and vigilance when starting new treatments in elderly populations. Regular monitoring and communication with healthcare providers can help ensure safe and effective use of the medicine.
What are the most common side effects of Ursodeoxycholic acid?
A side effect is an unwanted symptom caused by medical treatment. Common side effects of Ursodeoxycholic acid include diarrhea, nausea, and abdominal pain. These effects are generally mild and occur in a small percentage of users. It's important to note that new symptoms can appear when starting any medication, which may be unrelated or temporary. Always consult a healthcare provider before stopping any medication.
Who should avoid taking Ursodeoxycholic acid?
Ursodeoxycholic acid should not be used in individuals with complete biliary obstruction or known hypersensitivity to the drug. Caution is needed in patients with liver disease or gallstones. Always inform your healthcare provider about any medical conditions or allergies before starting this medication.
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