Terazosin
Hypertension, Prostatic Hyperplasia ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Alpha-Adrenergic Blocker
Controlled Drug Substance
NO
Terazosin
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Click HereSummary
Terazosin is used to treat symptoms of benign prostatic hyperplasia (BPH), a condition that causes an enlarged prostate, and high blood pressure.
Terazosin is an alpha-blocker that works by relaxing the muscles in the bladder neck and prostate, improving urine flow. It also relaxes blood vessels, allowing blood to flow more easily, which helps lower blood pressure.
The usual daily dose for adults starts at 1 mg at bedtime. The dose can be increased based on response and tolerance. For hypertension, the dose can range from 1 mg to 5 mg daily, with some patients requiring up to 20 mg per day.
Common side effects include dizziness, weakness, headache, and nasal congestion. Serious adverse effects can include fainting and a painful, prolonged erection.
Terazosin can cause dizziness, lightheadedness, and fainting, especially after the first dose or when the dose is increased. It is contraindicated in patients with known hypersensitivity to the drug.
Indications and Purpose
How does one know if Terazosin is working?
The benefit of Terazosin is evaluated by monitoring the improvement in symptoms of benign prostatic hyperplasia (BPH) and the reduction in blood pressure for hypertension. For BPH, symptom scores and peak urine flow rates are assessed to determine effectiveness. For hypertension, regular blood pressure checks are necessary to ensure the medication is effectively lowering blood pressure. Patients should keep all appointments with their doctor to monitor their response to Terazosin and adjust the dosage if needed.
How does Terazosin work?
Terazosin is an alpha-blocker that works by relaxing smooth muscles in the bladder neck and prostate, which helps relieve symptoms of benign prostatic hyperplasia (BPH). It also relaxes blood vessels, allowing blood to flow more easily, which helps lower blood pressure. By blocking alpha-1 adrenoceptors, Terazosin reduces bladder outlet obstruction and decreases peripheral vascular resistance, contributing to its therapeutic effects.
Is Terazosin effective?
Clinical studies have shown that Terazosin effectively improves symptoms of benign prostatic hyperplasia (BPH) and increases peak urine flow rates. In placebo-controlled studies, Terazosin significantly improved symptoms and urine flow compared to placebo. For hypertension, Terazosin has been shown to lower blood pressure by relaxing blood vessels, making it easier for blood to flow. These effects have been observed in both short-term and long-term studies, demonstrating its effectiveness in managing these conditions.
What is Terazosin?
Terazosin is commonly used to treat symptoms of benign prostatic hyperplasia (BPH) and high blood pressure (hypertension). It works by relaxing the muscles of the bladder and prostate to improve urine flow and by relaxing blood vessels to lower blood pressure. This medication helps manage symptoms but does not cure the underlying conditions. Regular monitoring and consultation with a doctor are important for effective treatment.
What is Terazosin used for?
Terazosin is indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH) and hypertension (high blood pressure). For BPH, it helps relieve symptoms such as difficulty urinating and weak urine flow. For hypertension, it lowers blood pressure by relaxing blood vessels, reducing the risk of complications like heart disease and stroke. It can be used alone or in combination with other medications for these conditions.
Directions for Use
For how long do I take Terazosin?
Terazosin is typically used as a long-term treatment for both benign prostatic hyperplasia (BPH) and hypertension. It is important to continue taking the medication even if you feel well, as it controls symptoms but does not cure the underlying conditions. The duration of use should be determined by your doctor based on your specific health needs and response to the medication.
How do I take Terazosin?
Terazosin should be taken exactly as prescribed by your doctor, usually once a day at bedtime. It can be taken with or without food. There are no specific food restrictions, but it's important to follow your doctor's dietary advice, especially if you are managing high blood pressure. If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. Do not double up on doses.
How long does it take for Terazosin to start working?
Terazosin may take 4 to 6 weeks or longer to show the full benefit for symptoms of benign prostatic hyperplasia (BPH). For high blood pressure, the effects can be observed more quickly, but it may still take some time to achieve optimal blood pressure control. It's important to continue taking the medication as prescribed and attend regular check-ups with your doctor to monitor your progress.
How should I store Terazosin?
Terazosin should be stored in its original container, tightly closed, and kept out of reach of children. It should be stored at room temperature, away from light, excess heat, and moisture, so avoid storing it in the bathroom. It's important to keep all medications out of sight and reach of children, as many containers are not child-resistant. For disposal, use a medicine take-back program if available, or consult your pharmacist or local waste disposal company for guidance.
What is the usual dose of Terazosin?
The usual daily dose for adults with benign prostatic hyperplasia (BPH) starts at 1 mg at bedtime, which can be increased to 2 mg, 5 mg, or 10 mg once daily based on response and tolerance. For hypertension, the dose also starts at 1 mg at bedtime and can be increased to achieve the desired blood pressure response, typically ranging from 1 mg to 5 mg daily, with some patients requiring up to 20 mg per day. There is no established dose for children as safety and effectiveness have not been determined for pediatric use.
Warnings and Precautions
Can I take Terazosin with other prescription drugs?
Terazosin can interact with other antihypertensive agents, such as diuretics and beta-blockers, potentially leading to an increased risk of hypotension. Caution is advised when used with calcium channel blockers like verapamil, as it may enhance the blood pressure-lowering effects. Patients should inform their doctor about all medications they are taking, including over-the-counter drugs and supplements, to avoid potential interactions. Dosage adjustments may be necessary to ensure safe and effective use.
Can Terazosin be taken safely while breastfeeding?
It is not known whether Terazosin is excreted in breast milk. Because many drugs are excreted in breast milk, caution should be exercised when Terazosin is administered to a nursing woman. Breastfeeding mothers should discuss the potential risks and benefits with their doctor to determine the best course of action for their specific situation.
Can Terazosin be taken safely while pregnant?
Terazosin is not recommended during pregnancy unless the potential benefit justifies the potential risk to the mother and fetus. There are no adequate and well-controlled studies in pregnant women, and the safety of Terazosin in pregnancy has not been established. Animal studies have shown some adverse effects at high doses, but these findings may not directly apply to humans. Pregnant women should consult their doctor to weigh the risks and benefits before using Terazosin.
Is it safe to drink alcohol while taking Terazosin?
Drinking alcohol while taking Terazosin can increase the risk of side effects such as dizziness, lightheadedness, and fainting, especially when standing up quickly. Alcohol can enhance the blood pressure-lowering effects of Terazosin, leading to an increased risk of hypotension. It is advisable to limit alcohol consumption and discuss with your doctor how much alcohol, if any, is safe to consume while taking this medication.
Is it safe to exercise while taking Terazosin?
Terazosin may cause dizziness, lightheadedness, or fainting, especially when you first start taking it or when your dose is increased. These side effects can temporarily limit your ability to exercise safely. It is important to get up slowly from sitting or lying positions to reduce the risk of dizziness. If you experience these symptoms, avoid strenuous activities until you know how the medication affects you. Consult your doctor if you have concerns about exercising while taking Terazosin.
Is Terazosin safe for the elderly?
For elderly patients, Terazosin should be used with caution, especially for treating high blood pressure, as it may not be as safe or effective as other medications. Older adults are more susceptible to side effects like dizziness and fainting, which can increase the risk of falls. It's important for elderly patients to start with a low dose and have their blood pressure and symptoms monitored closely by their doctor. Discuss any concerns with your healthcare provider to ensure safe use.
Who should avoid taking Terazosin?
Important warnings for Terazosin include the risk of dizziness, lightheadedness, and fainting, especially after the first dose or when the dose is increased. It can cause a sudden drop in blood pressure, so caution is advised when standing up quickly. Terazosin is contraindicated in patients with known hypersensitivity to the drug. Patients should inform their doctor if they have prostate cancer, are pregnant, or are breastfeeding. It's also important to inform healthcare providers about Terazosin use before surgery, including eye surgery.
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