Solriamfetol
Sleepiness
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Dopamine and Norepinephrine Reuptake Inhibitor
Controlled Drug Substance
NO
Solriamfetol
Summary
Solriamfetol is used to treat excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea. It's designed to improve wakefulness in adults who experience significant sleepiness due to these conditions.
Solriamfetol works by increasing the levels of certain natural substances in the brain that help promote wakefulness. It is a dopamine and norepinephrine reuptake inhibitor, which means it increases the levels of these neurotransmitters in the brain, enhancing the brain's natural alertness mechanisms.
The usual daily dose of Solriamfetol for adults with narcolepsy is 75 mg to 150 mg once daily. For adults with obstructive sleep apnea, the dose ranges from 37.5 mg to 150 mg once daily. It is taken by mouth, with or without food, as soon as you wake up in the morning.
Common side effects of Solriamfetol include headache, nausea, decreased appetite, anxiety, and insomnia. Serious adverse effects can include increased blood pressure, heart rate, psychiatric symptoms, and potential for abuse.
Solriamfetol may increase blood pressure and heart rate, and can cause psychiatric symptoms like anxiety and insomnia. It has potential for abuse and should not be used by patients using monoamine oxidase inhibitors or those with severe renal impairment. It should not be used as a substitute for primary treatments for obstructive sleep apnea.
Indications and Purpose
How does Solriamfetol work?
Solriamfetol acts as a dopamine and norepinephrine reuptake inhibitor, increasing the levels of these neurotransmitters in the brain. This action helps promote wakefulness and alertness, reducing excessive daytime sleepiness in individuals with narcolepsy or obstructive sleep apnea.
Is Solriamfetol effective?
Clinical studies have shown that Solriamfetol improves wakefulness in patients with excessive daytime sleepiness due to narcolepsy or obstructive sleep apnea. It has been demonstrated to increase the ability to stay awake and reduce sleepiness as measured by standardized tests like the Maintenance of Wakefulness Test and the Epworth Sleepiness Scale.
What is Solriamfetol?
Solriamfetol is used to treat excessive daytime sleepiness in adults with narcolepsy or obstructive sleep apnea. It works by increasing levels of certain natural substances in the brain that promote wakefulness. Solriamfetol is a wakefulness-promoting agent that helps improve alertness and reduce sleepiness.
Directions for Use
For how long do I take Solriamfetol?
Solriamfetol is typically used as a long-term treatment for managing excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea. The duration of use should be determined by a healthcare provider based on individual patient needs and response to the medication.
How do I take Solriamfetol?
Solriamfetol should be taken once daily, as soon as you wake up, with or without food. It is important to take it at the same time each day and avoid taking it within 9 hours of bedtime to prevent sleep disturbances. There are no specific food restrictions while taking Solriamfetol.
How long does it take for Solriamfetol to start working?
Solriamfetol typically starts working within 1 to 2 hours after taking it. Its effects on wakefulness and alertness can be observed relatively quickly, helping to reduce excessive daytime sleepiness.
How should I store Solriamfetol?
Store Solriamfetol in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and in a safe place to prevent accidental or intentional misuse. Track the number of tablets to ensure none are missing.
What is the usual dose of Solriamfetol?
For adults with narcolepsy, the usual dose of Solriamfetol is 75 mg to 150 mg once daily. For adults with obstructive sleep apnea, the dose starts at 37.5 mg and can be increased to 150 mg once daily. Solriamfetol is not recommended for children as its safety and effectiveness have not been established in pediatric patients.
Warnings and Precautions
Can I take Solriamfetol with other prescription drugs?
Solriamfetol should not be used with monoamine oxidase inhibitors due to the risk of hypertensive reactions. Caution is advised when used with other drugs that increase blood pressure or heart rate. Always inform your healthcare provider of all medications you are taking to avoid interactions.
Can Solriamfetol be taken safely while breastfeeding?
Solriamfetol is present in breast milk, and its effects on infants are not well understood. Breastfeeding mothers should monitor infants for signs of agitation, insomnia, and reduced weight gain. Discuss with your healthcare provider to weigh the benefits and risks of continuing Solriamfetol while breastfeeding.
Can Solriamfetol be taken safely while pregnant?
There is limited data on the use of Solriamfetol during pregnancy. Animal studies have shown potential risks, but human data is insufficient. Pregnant women should only use Solriamfetol if the potential benefits justify the risks. A pregnancy registry is available to monitor outcomes.
Is it safe to exercise while taking Solriamfetol?
Solriamfetol does not inherently limit the ability to exercise. However, it can increase heart rate and blood pressure, which might affect physical activity. If you experience any unusual symptoms during exercise, such as chest pain or shortness of breath, consult your healthcare provider.
Is Solriamfetol safe for the elderly?
Elderly patients may have decreased renal function, which can affect how Solriamfetol is processed in the body. It is important to adjust the dosage based on kidney function and monitor for side effects. Close monitoring and possibly lower doses are recommended for elderly patients.
Who should avoid taking Solriamfetol?
Solriamfetol can increase blood pressure and heart rate, so it should be used cautiously in patients with cardiovascular issues. It is contraindicated with monoamine oxidase inhibitors due to the risk of hypertensive reactions. Patients should be monitored for psychiatric symptoms and avoid driving until they know how the medication affects them.