Repotrectinib
NA
.svg)
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Repotrectinib
Summary
Repotrectinib is used to treat specific types of non-small cell lung cancer and solid tumors that have certain gene fusions. It is indicated for adults with lung cancer that has spread and for adults and children aged 12 years and older with advanced or metastatic solid tumors.
Repotrectinib works by blocking certain proteins, specifically abnormal ones that signal cancer cells to multiply. This helps to slow down or stop the growth and spread of cancer cells.
For adults and children aged 12 years and older, the usual dose of Repotrectinib is 160 mg taken orally once daily for the first 14 days, then increased to 160 mg twice daily. The treatment continues until disease progression or unacceptable side effects occur.
Common side effects of Repotrectinib include dizziness, change in taste, peripheral neuropathy, constipation, and nausea. Serious adverse effects can include lung disease, liver toxicity, and skeletal fractures.
Important warnings for Repotrectinib include the risk of central nervous system effects, lung disease, liver toxicity, muscle pain, high levels of uric acid, and skeletal fractures. The medication should be discontinued if severe adverse reactions occur. It is contraindicated in patients with known hypersensitivity to the drug.
Indications and Purpose
How does Repotrectinib work?
Repotrectinib works by targeting specific proteins in the body to treat certain conditions. This action helps manage the disease it's prescribed for. Discuss with your doctor to understand how it works for your specific health needs.
Is Repotrectinib effective?
Repotrectinib is used to treat specific conditions as determined by your doctor. Its effectiveness is supported by clinical studies for its approved indications. Discuss with your healthcare provider to understand how it works for your specific health needs.
What is Repotrectinib?
Repotrectinib is a medication used to treat specific conditions as determined by your doctor. It works by targeting certain proteins in the body. Discuss with your healthcare provider to understand its use for your health needs.
Directions for Use
For how long do I take Repotrectinib?
Repotrectinib is usually taken as long as prescribed by your doctor for your specific condition. The duration depends on your response and any side effects. Always consult your doctor before changing or stopping your treatment.
How do I dispose of Repotrectinib?
Dispose of Repotrectinib by taking it to a drug take-back program or collection site. If unavailable, mix it with undesirable substances like used coffee grounds, seal in a plastic bag, and throw it away. This prevents harm to people and the environment.
How do I take Repotrectinib?
Repotrectinib should be taken as prescribed by your doctor. The specific instructions regarding dose timing, frequency, and whether it should be taken with food will be provided by your healthcare provider. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Do not double up on doses. Always follow your doctor's advice on dietary or beverage restrictions while taking this medication.
How long does it take for Repotrectinib to start working?
The time it takes for Repotrectinib to work varies. Some effects may be noticed shortly after starting, but full benefits might take weeks or months. Factors like your condition and overall health can affect how quickly it works. Follow your doctor's instructions for best results.
How should I store Repotrectinib?
Store Repotrectinib at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in humid places like bathrooms. Always keep it out of children's reach.
What is the usual dose of Repotrectinib?
The usual starting dose of Repotrectinib for adults is determined by your doctor based on your specific condition. The frequency and any necessary dose adjustments will also be guided by your healthcare provider. Always follow your doctor's dosing instructions and discuss any concerns or side effects you experience.
Warnings and Precautions
Can I take Repotrectinib with other prescription drugs?
Major and moderate drug interactions with Repotrectinib are not well-documented. Always inform your doctor about all medications you're taking to prevent interactions and ensure safe treatment.
Can Repotrectinib be taken safely while breastfeeding?
The safety of Repotrectinib while breastfeeding is not well-established. It's unclear if it passes into breast milk. Discuss with your doctor to explore safer medication options if you wish to breastfeed.
Can Repotrectinib be taken safely while pregnant?
The safety of Repotrectinib during pregnancy is not well-established. Discuss with your doctor if you're pregnant or planning to become pregnant. They will help determine the safest treatment plan for you and your baby.
Does Repotrectinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Repotrectinib are not well-documented, but any new or worsening symptoms should be reported to your doctor. Serious side effects require immediate medical attention. Always communicate with your healthcare provider about any concerns.
Does Repotrectinib have any safety warnings?
Yes, Repotrectinib comes with safety warnings. It's important to follow your doctor's instructions and report any unusual symptoms. Not adhering to safety warnings can lead to serious health consequences. Always discuss any concerns with your healthcare provider to ensure safe use of the medication.
Is it safe to drink alcohol while taking Repotrectinib?
It's best to avoid alcohol while taking Repotrectinib. Alcohol can interfere with the medication and increase the risk of side effects. Discuss with your doctor for personalized advice on alcohol consumption during treatment.
Is it safe to exercise while taking Repotrectinib?
You can exercise while taking Repotrectinib, but stay hydrated to prevent dizziness. If you feel weak or dizzy, stop and rest. Consult your doctor if you have concerns about your exercise routine while on this medication.
Is it safe to stop Repotrectinib?
Stopping Repotrectinib suddenly can be risky. If you're taking it for a specific condition, stopping might worsen your health. Always consult your doctor before stopping the medication. They can guide you on how to safely discontinue or adjust your treatment.
Is Repotrectinib addictive?
Repotrectinib is not known to be addictive or habit-forming. It does not cause dependency or withdrawal symptoms. If you have concerns about medication dependence, discuss them with your doctor, but Repotrectinib does not carry this risk.
Is Repotrectinib safe for the elderly?
The elderly may be more vulnerable to medication risks. Discuss with your doctor to ensure Repotrectinib is safe for you. They will monitor for any specific risks or negative outcomes more frequently observed in elderly users.
What are the most common side effects of Repotrectinib?
Side effects are unwanted reactions to a medication. The common side effects of Repotrectinib are not well-documented. If you notice new symptoms after starting the medication, they might be temporary or unrelated. Always talk with your doctor before stopping any medication.
Who should avoid taking Repotrectinib?
Do not take Repotrectinib if you have known allergies to it or its ingredients. Discuss any medical conditions with your doctor to determine if Repotrectinib is safe for you. Your doctor will weigh the benefits and risks before prescribing it.
