Pregabalin
Postherpetic Neuralgia, Seizures ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
undefined
Controlled Drug Substance
YES
Pregabalin
Learn more about this medicine -
Click HereSummary
Pregabalin is primarily used to treat conditions such as neuropathic pain, fibromyalgia, and generalized anxiety disorder.
Pregabalin works by binding to specific calcium channels in the brain and spinal cord. This action reduces the release of neurotransmitters that cause pain and anxiety, thereby providing relief from these conditions.
Pregabalin capsules are taken orally, with or without food. The starting dose is usually 150 mg per day, taken in two doses of 75 mg each. The dose may be increased to 300 mg per day after one week, taken in two doses of 150 mg each. The maximum dose is 600 mg per day.
Common side effects of Pregabalin include dizziness, drowsiness, dry mouth, weight gain, and swelling in the hands or feet. Severe adverse effects can include allergic reactions, suicidal thoughts, mood changes, and rarely, muscle problems.
Pregabalin should be used with caution in people with a history of substance abuse, as it can be habit-forming. It is contraindicated in individuals with severe kidney problems. Pregnant or breastfeeding women should consult a doctor before use.
Indications and Purpose
How does one know if Pregabalin is working?
The benefit of Pregabalin is evaluated by monitoring the reduction in symptoms such as pain, seizure frequency, or anxiety levels. Regular follow-up appointments with your doctor will help assess the medication's effectiveness and determine if any dosage adjustments or alternative treatments are needed.
How does Pregabalin work?
Pregabalin works by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. This action reduces the release of neurotransmitters involved in pain transmission and seizure activity, helping to alleviate pain and control seizures.
Is Pregabalin effective?
Pregabalin is effective in managing neuropathic pain, fibromyalgia, and as an adjunctive therapy for partial-onset seizures. Clinical trials have shown significant pain reduction and improved seizure control in patients using Pregabalin compared to placebo. Its effectiveness is attributed to its ability to decrease pain signals from damaged nerves.
What is Pregabalin?
Pregabalin is used to treat neuropathic pain, fibromyalgia, and as an adjunctive therapy for partial-onset seizures. It works by binding to calcium channels in the central nervous system, reducing the release of neurotransmitters that transmit pain signals. This action helps decrease pain and control seizures.
What is Pregabalin used for?
Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, and as an adjunctive therapy for partial-onset seizures. It is also used to manage neuropathic pain associated with spinal cord injury.
Directions for Use
For how long do I take Pregabalin?
The duration of Pregabalin use varies depending on the condition being treated. It may be used for several weeks to months for conditions like neuropathic pain or fibromyalgia. Your doctor will determine the appropriate length of treatment based on your specific needs and response to the medication.
How do I dispose of Pregabalin?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How do I take Pregabalin?
Pregabalin can be taken with or without food. It's important to take it at the same time each day to maintain consistent blood levels. There are no specific food restrictions, but avoid alcohol as it can increase the risk of side effects like dizziness and drowsiness.
How long does it take for Pregabalin to start working?
Pregabalin may start to relieve symptoms within a week, but it can take several weeks to feel the full benefits. The time it takes to work can vary depending on the condition being treated and individual response. Consult your doctor if you have concerns about its effectiveness.
How should I store Pregabalin?
Store Pregabalin in its original container at room temperature, away from excess heat and moisture. Keep it out of reach of children and pets. Do not store it in the bathroom, and ensure the container is tightly closed to maintain the medication's effectiveness and safety.
What is the usual dose of Pregabalin?
For adults, the usual daily dose of Pregabalin ranges from 150 mg to 600 mg, divided into two or three doses. For children aged 1 month and older, the dose is based on body weight and ranges from 2.5 mg/kg to 10 mg/kg per day, not exceeding 600 mg per day. Always follow your doctor's specific dosage instructions.
Warnings and Precautions
Can I take Pregabalin with other prescription drugs?
Pregabalin can interact with central nervous system depressants like opioids, benzodiazepines, and alcohol, increasing the risk of sedation and respiratory depression. It's important to inform your doctor about all medications you're taking to avoid potential interactions and ensure safe use of Pregabalin.
Can I take Pregabalin with vitamins or supplements?
There are no well-documented interactions between Pregabalin and vitamins or supplements. However, it's important to inform your healthcare provider about all medications and supplements you're taking. This helps them monitor for any potential interactions or nutrient depletions and ensure your treatment is safe and effective.
Can Pregabalin be taken safely while breastfeeding?
Pregabalin is excreted in breast milk, and its effects on nursing infants are unknown. Breastfeeding is not recommended while taking Pregabalin. Consult your doctor to discuss the risks and benefits and explore alternative treatments if necessary.
Can Pregabalin be taken safely while pregnant?
Pregabalin should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. Some studies suggest a possible risk of birth defects, but data is limited. Pregnant women should consult their doctor to weigh the risks and benefits before using Pregabalin.
Does Pregabalin have adverse effects?
Adverse effects are unwanted or harmful effects caused by a medicine. Pregabalin can cause dizziness, drowsiness, dry mouth, swelling, and weight gain. These are common but usually mild. Rarely, it can cause serious effects like allergic reactions, vision changes, or suicidal thoughts, which need immediate medical attention. Always report new symptoms to your doctor and consult them before stopping the medicine.
Does Pregabalin have any safety warnings?
Pregabalin comes with safety warnings, including the risk of dizziness and drowsiness, which can affect your ability to drive or operate machinery. It may also cause allergic reactions, so watch for symptoms like rash or swelling. There's a warning about potential suicidal thoughts, so report mood changes to your doctor. Always follow your healthcare provider's instructions and report any unusual symptoms.
Is it safe to drink alcohol while taking Pregabalin?
Drinking alcohol while taking Pregabalin can increase the risk of side effects such as dizziness, drowsiness, and difficulty concentrating. It is generally advised to avoid alcohol to prevent these enhanced effects and ensure safety while on this medication.
Is it safe to exercise while taking Pregabalin?
Pregabalin may cause dizziness, drowsiness, and coordination issues, which can affect your ability to exercise safely. If you experience these side effects, it is advisable to avoid strenuous activities until you know how the medication affects you. Consult your doctor for personalized advice on exercise while taking Pregabalin.
Is it safe to stop Pregabalin?
Pregabalin is often used for long-term management of conditions like nerve pain or epilepsy. Stopping it suddenly can lead to withdrawal symptoms such as anxiety, insomnia, nausea, or seizures. It's important to consult your doctor before stopping Pregabalin, as they may need to gradually reduce your dose to prevent these effects.
Is Pregabalin addictive?
Pregabalin does have the potential to be habit-forming. It can cause physical dependence, where your body gets used to the medicine, and psychological dependence, where you feel you need it. Warning signs include taking more than prescribed or feeling anxious without it. To avoid addiction, follow your doctor's instructions closely and don't increase your dose without consulting them.
Is Pregabalin safe for the elderly?
Elderly patients may be more sensitive to the side effects of Pregabalin, such as dizziness and drowsiness, which can increase the risk of falls. Dose adjustments may be necessary due to decreased renal function. It's important for elderly patients to be closely monitored by their healthcare provider while taking Pregabalin.
What are the most common side effects of Pregabalin?
A side effect is an unwanted reaction to a medicine. Common side effects of Pregabalin include dizziness, drowsiness, dry mouth, swelling, and weight gain. These effects are usually mild and may go away as your body adjusts. It's important to remember that new symptoms might not be related to the medicine. Always talk to your healthcare provider before stopping any medication.
Who should avoid taking Pregabalin?
Pregabalin may cause serious side effects like allergic reactions, suicidal thoughts, and respiratory depression. It should be used cautiously in patients with a history of substance abuse, and those with renal impairment may require dose adjustments. Pregabalin is contraindicated in patients with known hypersensitivity to the drug or its components.
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