Mycophenolate mofetil
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Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
NA
Controlled Drug Substance
NO
Mycophenolate mofetil
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Click HereSummary
Mycophenolate mofetil is primarily used to prevent organ transplant rejection in patients who have had a kidney, liver, or heart transplant. It can also be used for autoimmune diseases like lupus when other treatments have failed.
Mycophenolate mofetil works by suppressing the immune system. It blocks an enzyme called inosine monophosphate dehydrogenase, which is involved in the production of immune cells. This reduces the immune system's ability to attack the transplanted organ, thus preventing rejection.
For adults, the usual dose of Mycophenolate mofetil is 1.5 grams taken twice daily. For children, the dose depends on weight, usually 600 mg/m2 twice daily. The medicine is taken orally, and should be swallowed whole without crushing or chewing.
Common side effects of Mycophenolate mofetil include nausea, diarrhea, vomiting, and infections due to a weakened immune system. In rare cases, it can cause fatigue, confusion, and sleep disturbances.
Mycophenolate mofetil is not recommended for people with severe infections, pregnant women due to risk of fetal harm, or those allergic to its ingredients. It can also interact with certain other medications, so it's important to inform your doctor about all the medications you are taking.
Indications and Purpose
How does Mycophenolate mofetil work?
It inhibits the production of immune cells by blocking the enzyme inosine monophosphate dehydrogenase, suppressing the immune system's response to the transplanted organ.
How does one know if Mycophenolate mofetil is working?
Routine lab tests, including organ function tests, help monitor its effectiveness. Stable transplant function without rejection episodes indicates the medicine is working.
Is Mycophenolate mofetil effective?
Yes, it is effective in preventing organ transplant rejection. Clinical studies have demonstrated its success in reducing rejection episodes when combined with other immunosuppressive therapies.
What is Mycophenolate mofetil?
Mycophenolate mofetil is an immunosuppressive medication primarily used to prevent organ transplant rejection. It works by suppressing the immune system, reducing its ability to attack the transplanted organ while maintaining overall balance.
What is Mycophenolate mofetil used for?
It is used to prevent rejection in kidney, liver, or heart transplant patients. It is sometimes used for autoimmune diseases like lupus when other treatments fail.
Directions for Use
For how long do I take Mycophenolate mofetil?
It is generally taken long-term to maintain organ transplant health and prevent rejection. Duration depends on your doctor’s recommendation and ongoing monitoring of your condition.
How do I take Mycophenolate mofetil?
Take this medication on an empty stomach, one hour before or two hours after meals, unless otherwise advised. Swallow the tablets whole without crushing or chewing them.
How long does it take for Mycophenolate mofetil to start working?
Its effects begin within a few hours but the full benefit may take weeks to assess, especially in transplant management or autoimmune treatment.
How should I store Mycophenolate mofetil?
Store it at room temperature, away from moisture, heat, and direct sunlight. Keep it out of reach of children.
What is the usual dose of Mycophenolate mofetil?
For adults, the usual dose is 1–1.5 grams taken twice daily. For children, the dose depends on weight (usually 600 mg/m² twice daily). Always follow the prescribed dosage.
Warnings and Precautions
Can I take Mycophenolate mofetil with other prescription drugs?
Some drugs, such as cholestyramine, antivirals, or other immunosuppressants, may interact with this medication. Inform your doctor about all medications you are taking.
Can I take Mycophenolate mofetil with vitamins or supplements?
Avoid antacids or supplements containing magnesium, aluminum, or calcium within two hours of taking this medication, as they may reduce its absorption.
Can Mycophenolate mofetil be taken safely while breastfeeding?
No, it is not recommended as it may pass into breast milk and harm the baby. Consult your doctor for alternative options.
Can Mycophenolate mofetil be taken safely while pregnant?
No, it is not safe during pregnancy due to the risk of birth defects and miscarriage. Women should use effective contraception while on this medication.
Is it safe to drink alcohol while taking Mycophenolate mofetil?
Moderate alcohol use is usually safe, but avoid excessive drinking as it may weaken your immune system further. Consult your doctor for guidance.
Is it safe to exercise while taking Mycophenolate mofetil?
Yes, light to moderate exercise is typically safe. Avoid activities that risk injury or strain, especially if your immune system is suppressed. Stay hydrated and consult your doctor before starting a new routine.
Is Mycophenolate mofetil safe for the elderly?
Elderly patients can take it, but they may have a higher risk of infections and gastrointestinal side effects, requiring close monitoring by their doctor.
Who should avoid taking Mycophenolate mofetil?
It is not recommended for people with severe infections, pregnant women (due to risk of fetal harm), or those allergic to its ingredients. Consult your doctor for specific concerns.
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