Mifepristone

Ectopic Pregnancy, Brain Neoplasms ... show more

Drug Status

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Government Approvals

US(FDA), UK(BNF)

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WHO Essential Medicine

NO

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Known Teratogen

NO

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Pharmaceutical Class

Progestin Antagonist

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Controlled Drug Substance

NO

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Drug Ingredient

Mifepristone

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Summary

  • Mifepristone is primarily used for medical abortion in pregnancies up to 10 weeks and for treating Cushing's syndrome, a condition characterized by high blood sugar levels due to excess cortisol.

  • Mifepristone works by blocking progesterone, a hormone necessary for pregnancy. This results in the detachment of the pregnancy from the uterus. In Cushing's syndrome, it helps reduce high blood sugar by blocking cortisol effects.

  • For medical abortion, the typical dose is 200 mg taken once, followed by misoprostol 800 mcg after 24-48 hours. For Cushing's syndrome, the dose starts at 300 mg per day and may be increased based on response. Mifepristone should be taken orally with water.

  • Common side effects include nausea, vomiting, cramping, diarrhea, headache, and dizziness. Serious risks include excessive bleeding, infection, and incomplete abortion.

  • Women with ectopic pregnancy, bleeding disorders, severe anemia, or adrenal insufficiency should avoid it. It is also not recommended for those with liver disease, kidney problems, or heart conditions. Always consult a doctor before taking Mifepristone.

Indications and Purpose

Directions for Use

Warnings and Precautions