Mefenamic acid
Menorrhagia, Dysmenorrhea ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Possible
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug
Controlled Drug Substance
NO
Mefenamic acid
Learn more about this medicine -
Click HereSummary
Mefenamic acid is used for the relief of mild to moderate pain such as headaches, dental pain, muscle pain, and menstrual cramps. It's also used in the treatment of inflammatory conditions like arthritis and can provide short-term relief of fever in some cases.
Mefenamic acid is a pain reliever and anti-inflammatory medicine. It works by stopping the body from making substances that cause pain and swelling. It's quickly absorbed when taken orally, with its effects lasting for a couple of hours.
For adults and teens 14 and older, you start with a large dose (500mg), then take smaller doses (250mg) every six hours as needed, but only for up to a week for sudden sharp pain. For period pain, start with the large dose when your period starts and take smaller doses every six hours for two or three days.
Mefenamic acid can cause stomach upset, nausea, heartburn, and may affect sleep. It can sometimes cause headaches, skin rashes, dizziness, and swelling. Rarely, it can lead to serious effects like heart attacks, strokes, severe liver damage, and severe skin reactions.
Mefenamic acid should not be taken if you're allergic to it or similar medicines like aspirin. It can increase your chances of a heart attack, stroke or bleeding. It's risky around heart surgery and can cause stomach and intestinal problems. It should not be taken during pregnancy, especially after 20 weeks, and only small amounts can pass to a baby through breast milk.
Indications and Purpose
What is Mefenamic acid used for?
Mefenamic acid is indicated for the relief of mild to moderate pain, including menstrual pain, and for the treatment of primary dysmenorrhea. It is also used for short-term pain relief in conditions like arthritis and other inflammatory disorders.
How does Mefenamic acid work?
Mefenamic acid works by inhibiting the enzymes COX-1 and COX-2, which are involved in the production of prostaglandins. Prostaglandins are substances that cause inflammation, pain, and fever, so by reducing their production, Mefenamic acid alleviates these symptoms.
Is Mefenamic acid effective?
Clinical trials have shown that Mefenamic acid is effective in treating mild to moderate pain, including menstrual pain. It works by inhibiting the production of substances in the body that cause inflammation and pain, providing relief from symptoms.
How does one know if Mefenamic acid is working?
The benefit of Mefenamic acid is evaluated by monitoring the reduction in pain and inflammation symptoms. Regular follow-ups with your doctor can help assess its effectiveness and adjust the dosage if necessary.
Directions for Use
What is the usual dose of Mefenamic acid?
For adults and adolescents aged 14 years and older, the usual dose of Mefenamic acid is 500 mg as an initial dose, followed by 250 mg every 6 hours as needed, typically not exceeding one week. For children under 14, safety and effectiveness have not been established, so consult a doctor for appropriate dosing.
How do I take Mefenamic acid?
Take Mefenamic acid with food to reduce the risk of gastrointestinal upset. There are no specific food restrictions, but avoid alcohol to minimize the risk of stomach bleeding.
For how long do I take Mefenamic acid?
Mefenamic acid is typically used for short-term relief of pain, usually not exceeding one week. For menstrual pain, it is often taken at the onset of symptoms and continued for 2 to 3 days as needed.
How long does it take for Mefenamic acid to start working?
Mefenamic acid typically starts working within 2 to 4 hours after taking a dose, providing relief from pain and inflammation.
How should I store Mefenamic acid?
Store Mefenamic acid in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children to prevent accidental ingestion.
Warnings and Precautions
Who should avoid taking Mefenamic acid?
Mefenamic acid carries risks of serious cardiovascular events and gastrointestinal bleeding. It is contraindicated in patients with a history of allergic reactions to NSAIDs, recent heart surgery, or active gastrointestinal bleeding. Always consult your doctor before use, especially if you have underlying health conditions.
Can I take Mefenamic acid with other prescription drugs?
Mefenamic acid can interact with anticoagulants, other NSAIDs, SSRIs, and SNRIs, increasing the risk of bleeding. It may also affect the efficacy of antihypertensives and diuretics. Always inform your doctor of all medications you are taking to avoid adverse interactions.
Can I take Mefenamic acid with vitamins or supplements?
There are no well-documented confirmed interactions between Mefenamic acid and vitamins or supplements. There is no evidence that it causes nutrient depletion or requires supplementation. However, it's important to inform your healthcare provider about all medications and supplements you're taking to avoid potential interactions. They can provide personalized advice and monitor for any adverse effects.
Can Mefenamic acid be taken safely while pregnant?
Mefenamic acid is not recommended during pregnancy, especially after 20 weeks, due to risks of fetal harm such as premature closure of the ductus arteriosus and renal dysfunction. Consult your doctor for safer alternatives if you are pregnant or planning to become pregnant.
Can Mefenamic acid be taken safely while breastfeeding?
Trace amounts of Mefenamic acid may be present in breast milk. Due to potential risks to the nursing infant, consult your doctor to weigh the benefits and risks before using this medication while breastfeeding.
Is Mefenamic acid safe for the elderly?
Elderly patients are at a higher risk for serious side effects from Mefenamic acid, such as gastrointestinal bleeding and cardiovascular events. It's important to use the lowest effective dose for the shortest duration possible and to monitor for any adverse effects closely.
Is it safe to exercise while taking Mefenamic acid?
Mefenamic acid does not specifically limit the ability to exercise. However, if you experience side effects like dizziness or shortness of breath, it may be wise to avoid strenuous activities and consult your doctor for advice.
Is it safe to drink alcohol while taking Mefenamic acid?
Drinking alcohol while taking Mefenamic acid can increase the risk of gastrointestinal bleeding, ulcers, or holes in the stomach or intestine. It's advisable to limit or avoid alcohol consumption to reduce these risks.
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