Fenofibrate
Coronary Artery Disease, Hypercholesterolemia ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Peroxisome Proliferator Receptor alpha Agonist
Controlled Drug Substance
No
Summary
Indications and Purpose
How does Fenofibrate work?
Fenofibrate works by activating peroxisome proliferator-activated receptor alpha (PPARĪ±), which increases the breakdown and removal of triglyceride-rich particles from the blood. It also reduces the production of certain proteins that inhibit fat breakdown, leading to lower triglyceride levels and increased HDL cholesterol.
Is Fenofibrate effective?
Fenofibrate is effective in reducing triglyceride levels and increasing HDL cholesterol in patients with hypertriglyceridemia and mixed dyslipidemia. Clinical trials have shown significant improvements in lipid profiles, although it has not been proven to reduce cardiovascular disease morbidity or mortality.
What is Fenofibrate?
Fenofibrate is used to reduce high levels of cholesterol and triglycerides in the blood. It works by activating an enzyme that breaks down fats in the blood, helping to lower triglyceride levels and increase HDL (good) cholesterol. This can help reduce the risk of heart disease.
Directions for Use
For how long do I take Fenofibrate?
Fenofibrate is typically used as a long-term treatment to manage cholesterol and triglyceride levels. The duration of use depends on individual response and medical advice. Regular monitoring by a healthcare provider is essential to determine the ongoing need for the medication.
How do I dispose of Fenofibrate?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How do I take Fenofibrate?
Fenofibrate should be taken once daily, with or without food, depending on the brand. Some brands require it to be taken with a meal. Follow your doctor's instructions and check with your pharmacist if unsure. Maintain a low-fat, low-cholesterol diet while on this medication.
How long does it take for Fenofibrate to start working?
Fenofibrate may start to show effects on lipid levels within a few weeks, but it can take up to two months to see the full benefit. Regular blood tests will help monitor its effectiveness, and your doctor may adjust the dosage based on these results.
How should I store Fenofibrate?
Store Fenofibrate in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program.
What is the usual dose of Fenofibrate?
For adults, the usual daily dose of Fenofibrate is 160 mg taken once daily. The safety and effectiveness of Fenofibrate in children have not been established, so it is not recommended for pediatric use. Always follow your doctor's advice for the correct dosage.
Warnings and Precautions
Can Fenofibrate be taken safely while breastfeeding?
Fenofibrate is likely to be present in human milk and may cause serious adverse reactions in breastfed infants. Women are advised not to breastfeed during treatment with Fenofibrate and for 5 days after the final dose. Consult your doctor for personalized advice.
Can Fenofibrate be taken safely while pregnant?
Fenofibrate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There is limited data on its use in pregnant women, and animal studies have shown adverse effects at high doses. Consult your doctor for personalized advice.
Can I take Fenofibrate with other prescription drugs?
Fenofibrate can interact with statins, increasing the risk of muscle damage. It may also enhance the effects of anticoagulants, increasing bleeding risk. Caution is advised when used with immunosuppressants due to potential renal effects. Always inform your doctor of all medications you are taking.
Does Fenofibrate have adverse effects?
Adverse effects are unwanted or harmful effects caused by a medicine. Fenofibrate can cause adverse effects like stomach pain, back pain, headache, and respiratory issues. Serious but rare effects include muscle pain or weakness, which may indicate muscle damage, and liver problems. It's important to report any new or severe symptoms to your healthcare provider and not stop the medicine without consulting them.
Does Fenofibrate have any safety warnings?
Fenofibrate has safety warnings related to liver and muscle health. It can cause liver damage, so watch for symptoms like yellowing skin or eyes, dark urine, or severe stomach pain. It can also cause muscle damage, so be alert for unexplained muscle pain or weakness. If you notice these symptoms, contact your doctor immediately.
Is Fenofibrate addictive?
Fenofibrate is not addictive and has no known potential for dependence. There are no behaviors or warning signs of addiction associated with this medicine. You can take it as prescribed without worrying about addiction.
Is Fenofibrate safe for the elderly?
For elderly patients, it is important to assess renal function before starting Fenofibrate and periodically thereafter. Dosage adjustments may be necessary based on kidney function. Elderly patients are more likely to have renal impairment, which can increase the risk of side effects.
Is it safe to drink alcohol while taking Fenofibrate?
Drinking alcohol, especially in large amounts, can affect the liver and may increase the risk of liver damage when taking Fenofibrate. It is advisable to limit alcohol consumption while on this medication. Consult your doctor for personalized advice.
Is it safe to exercise while taking Fenofibrate?
Fenofibrate does not typically limit the ability to exercise. However, if you experience muscle pain, weakness, or tenderness, it is important to stop exercising and consult your doctor, as these could be signs of a serious side effect.
Is it safe to stop Fenofibrate?
Fenofibrate is used for long-term management of high cholesterol, which is a chronic condition. Stopping it suddenly can lead to a rise in cholesterol levels, increasing the risk of heart disease or stroke. There are no known withdrawal symptoms, but it's crucial to consult your doctor before stopping to avoid any potential health risks.
What are the most common side effects of Fenofibrate?
A side effect is an unwanted effect of a medicine. Common side effects of Fenofibrate include stomach pain, back pain, headache, and respiratory issues. These effects are not experienced by everyone and may be unrelated to the medicine. Always talk to your healthcare provider before stopping any medication.
Who should avoid taking Fenofibrate?
Fenofibrate is contraindicated in patients with severe renal impairment, active liver disease, pre-existing gallbladder disease, and known hypersensitivity to the drug. It may cause liver enzyme elevations, muscle toxicity, and increased bleeding risk when used with anticoagulants. Regular monitoring is essential.
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