Dofetilide
Atrial Fibrillation, Atrial Flutter
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Antiarrhythmic
Controlled Drug Substance
NO
Dofetilide
Summary
Dofetilide is used to treat irregular heartbeats, specifically atrial fibrillation and atrial flutter. It helps to restore and maintain a normal heart rhythm.
Dofetilide works by blocking a specific cardiac ion channel responsible for a type of potassium current in the heart. This action helps to prolong the cardiac action potential duration and refractory period, aiding in the restoration and maintenance of a normal heart rhythm.
The usual dose of Dofetilide for adults is typically 500 mcg taken orally twice daily. However, the dose may be adjusted based on kidney function and QT interval.
Common side effects of Dofetilide include headache, chest pain, dizziness, and nausea. Serious adverse effects can include a dangerous heart rhythm disorder known as Torsade de Pointes.
Dofetilide can cause serious heart rhythm problems, including Torsade de Pointes. It is not recommended for patients with long QT syndrome, severe kidney impairment, or those taking certain medications that interact with Dofetilide. Close monitoring in a hospital setting is required when starting or restarting treatment.
Indications and Purpose
How does Dofetilide work?
Dofetilide works by blocking the cardiac ion channel responsible for the rapid component of the delayed rectifier potassium current, IKr. This action prolongs the cardiac action potential duration and refractory period, helping to restore and maintain a normal heart rhythm.
How does one know if Dofetilide is working?
The benefit of Dofetilide is evaluated through regular monitoring of heart rhythm and kidney function. Patients should have their heart rhythm checked regularly to ensure the medication is working effectively and safely. Kidney function tests are also important to adjust dosing as needed.
Is Dofetilide effective?
Clinical studies have shown that Dofetilide is effective in converting atrial fibrillation or atrial flutter to normal sinus rhythm and maintaining it. It has been proven to delay the recurrence of these conditions, especially in patients with symptomatic atrial fibrillation or flutter.
What is Dofetilide?
Dofetilide is used to treat irregular heartbeats, specifically atrial fibrillation and atrial flutter. It works by blocking certain electrical signals in the heart, helping to restore and maintain a normal heart rhythm. This medication is typically used in patients with symptomatic atrial fibrillation or flutter.
Directions for Use
For how long do I take Dofetilide?
Dofetilide is used for long-term management of atrial fibrillation or atrial flutter. It is not a cure but helps control the heart rhythm. Patients should continue taking it as prescribed by their doctor, even if they feel well, and should not stop without consulting their healthcare provider.
How do I take Dofetilide?
Dofetilide can be taken with or without food. Patients should follow their doctor's instructions regarding dosage and should not alter their dose without consulting their healthcare provider. There are no specific food restrictions, but patients should discuss any dietary concerns with their doctor.
How long does it take for Dofetilide to start working?
Dofetilide begins to work within a few hours of administration, with peak plasma concentrations occurring about 2 to 3 hours after taking the dose. However, the full therapeutic effect may take a few days to be observed as the medication reaches steady-state levels in the body.
How should I store Dofetilide?
Store Dofetilide at room temperature, between 59°F to 86°F (15°C to 30°C), away from moisture and humidity. Keep it in a tightly closed container and out of reach of children. Do not store it in the bathroom.
What is the usual dose of Dofetilide?
The usual dose of Dofetilide for adults is typically 500 mcg taken twice daily, but it may be adjusted based on kidney function and QT interval. Dofetilide is not recommended for use in children under 18 years of age, as its safety and effectiveness have not been established for this age group.
Warnings and Precautions
Can Dofetilide be taken safely while breastfeeding?
There is no information on the presence of Dofetilide in breast milk. Patients are advised not to breastfeed while taking Dofetilide to avoid potential harm to the infant. Consult your doctor for personalized advice.
Can Dofetilide be taken safely while pregnant?
Dofetilide should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. There are no adequate and well-controlled studies in pregnant women, so it is important to consult a healthcare provider to weigh the risks and benefits.
Can I take Dofetilide with other prescription drugs?
Dofetilide interacts with several medications, including cimetidine, verapamil, ketoconazole, and hydrochlorothiazide, which can increase its plasma concentration and risk of side effects. Patients should inform their doctor of all medications they are taking to avoid harmful interactions.
Is Dofetilide safe for the elderly?
Elderly patients may have decreased kidney function, which can affect how Dofetilide is processed in the body. Therefore, careful dose selection and monitoring of kidney function are important. Regular check-ups with a healthcare provider are recommended to ensure safe use.
Is it safe to exercise while taking Dofetilide?
Dofetilide does not specifically limit the ability to exercise. However, if you experience dizziness, shortness of breath, or any other side effects, it may affect your ability to exercise safely. Always consult your doctor before starting or continuing an exercise regimen while on this medication.
Who should avoid taking Dofetilide?
Dofetilide can cause serious heart rhythm problems, including Torsade de Pointes, a potentially life-threatening condition. It is contraindicated in patients with long QT syndrome, severe kidney impairment, or those taking certain medications that interact with Dofetilide. Close monitoring in a hospital setting is required when starting or restarting treatment.