Dofetilide
Atrial Fibrillation , Atrial Flutter
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Antiarrhythmic
Controlled Drug Substance
No
Summary
Dofetilide is used to treat irregular heartbeats, such as atrial fibrillation, which is a condition where the heart beats irregularly and often rapidly. It helps maintain a normal heart rhythm and is part of a comprehensive treatment plan to manage heart rhythm disorders effectively.
Dofetilide works by blocking certain electrical signals in the heart that can cause irregular heartbeats. It stabilizes the heart's electrical activity, helping to maintain a normal rhythm, similar to adjusting a radio to reduce static.
The usual starting dose of Dofetilide for adults is 500 micrograms taken twice daily. It is taken orally, which means by mouth, and should be swallowed whole with water. The dose may be adjusted based on kidney function and response to the medication.
Common side effects of Dofetilide include dizziness and headache. These effects vary from person to person and are generally mild. If you notice any new or worsening symptoms, it's important to contact your doctor immediately.
Dofetilide can cause serious heart rhythm problems, especially if you have low potassium or magnesium levels. It is not recommended for people with severe kidney problems or those allergic to it. Regular monitoring of heart rhythm and kidney function is necessary.
Indications and Purpose
How does Dofetilide work?
Dofetilide works by blocking certain electrical signals in the heart that can cause irregular heartbeats. Think of it like adjusting the settings on a radio to reduce static. By stabilizing the heart's electrical activity, Dofetilide helps maintain a normal rhythm. This makes it effective for treating conditions like atrial fibrillation.
Is Dofetilide effective?
Dofetilide is effective for treating certain types of irregular heartbeats, such as atrial fibrillation. It works by helping the heart maintain a normal rhythm. Clinical studies show Dofetilide can reduce the risk of hospitalization and improve heart rhythm control. Always follow your doctor's instructions and attend regular check-ups to monitor your condition.
What is Dofetilide?
Dofetilide is a medication used to treat certain types of irregular heartbeats, such as atrial fibrillation. It belongs to a class of drugs called antiarrhythmics, which help the heart maintain a normal rhythm. Dofetilide works by affecting the heart's electrical activity. It's used to prevent and treat irregular heartbeats and is often part of a comprehensive treatment plan.
Directions for Use
For how long do I take Dofetilide?
Dofetilide is usually a long-term medication for managing irregular heartbeats. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your Dofetilide treatment.
How do I dispose of Dofetilide?
Bring unused Dofetilide to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm. If you can't find a take-back program, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash.
How do I take Dofetilide?
Take Dofetilide exactly as prescribed by your doctor. It's usually taken twice daily, about 12 hours apart. Swallow the capsules whole with water; do not crush or chew them. You can take Dofetilide with or without food. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Do not double up on doses. Always follow your doctor's specific instructions.
How long does it take for Dofetilide to start working?
Dofetilide begins working shortly after you take it, but it may take a few days to notice improvements in your heart rhythm. The full therapeutic effect can take several weeks. How quickly it works can depend on your overall health and kidney function. Take it exactly as prescribed for the best results.
How should I store Dofetilide?
Store Dofetilide at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep Dofetilide out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Dofetilide?
The usual starting dose of Dofetilide for adults is 500 micrograms taken twice daily. Your doctor may adjust the dose based on your kidney function and response to the medication. The maximum recommended dose is 500 micrograms twice daily. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Dofetilide be taken safely while breastfeeding?
Dofetilide is not recommended while breastfeeding. Limited information is available on whether it passes into human breast milk. If you're taking Dofetilide and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Dofetilide be taken safely while pregnant?
Dofetilide is not recommended during pregnancy due to potential risks to the unborn baby. Limited information is available on its safety in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your heart condition. Your doctor can help create a pregnancy-specific treatment plan.
Can I take Dofetilide with other prescription drugs?
Dofetilide has major interactions with certain medications, such as cimetidine and ketoconazole, which can increase the risk of heart rhythm problems. Always inform your doctor about all medicines you take to avoid interactions. Your doctor will assess the risks and benefits before prescribing Dofetilide.
Does Dofetilide have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Dofetilide include dizziness and headache. Serious effects can include heart rhythm problems. If you notice any new or worsening symptoms, contact your doctor immediately. Regular monitoring by your healthcare provider is important to manage any potential adverse effects.
Does Dofetilide have any safety warnings?
Yes, Dofetilide has important safety warnings. It can cause serious heart rhythm problems, especially if you have low potassium or magnesium levels. Regular monitoring of your heart rhythm and kidney function is necessary. If you experience symptoms like dizziness, fainting, or a fast heartbeat, seek medical help immediately. Always follow your doctor's instructions and attend all scheduled appointments.
Is Dofetilide addictive?
Dofetilide is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Dofetilide works by affecting the heart's electrical activity to maintain a normal rhythm. It doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Dofetilide doesn't carry this risk.
Is Dofetilide safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Dofetilide, such as dizziness and heart rhythm problems. Regular monitoring by a healthcare provider is important to ensure safety. Dose adjustments may be necessary based on kidney function and overall health. Always follow your doctor's instructions and attend all scheduled appointments.
Is it safe to drink alcohol while taking Dofetilide?
It's best to avoid alcohol while taking Dofetilide. Alcohol can increase the risk of side effects like dizziness and may affect your heart rhythm. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like dizziness or palpitations. Talk with your doctor about alcohol use while taking Dofetilide for personalized advice.
Is it safe to exercise while taking Dofetilide?
You can exercise while taking Dofetilide, but be cautious. This medication can cause dizziness, which might affect your ability to exercise safely. To exercise safely, start slowly and avoid strenuous activities until you know how the medication affects you. If you feel dizzy or lightheaded, stop exercising and rest. Talk with your doctor if you have concerns.
Is it safe to stop Dofetilide?
Stopping Dofetilide suddenly can cause serious problems, such as a return of irregular heartbeats. Always talk with your doctor before stopping Dofetilide. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Dofetilide?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Dofetilide include dizziness and headache. These effects vary from person to person. If you notice new symptoms after starting Dofetilide, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Dofetilide?
Don't take Dofetilide if you have severe kidney problems or are allergic to it. It's also contraindicated with certain medications that can cause serious heart rhythm problems. Always inform your doctor about all medicines you take. They will assess the risks and benefits before prescribing Dofetilide.
