Dicyclomine + Simethicone
Find more information about this combination medication at the webpages for Simethicone and Dicyclomine simethicone and
Irritable Bowel Syndrome
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Advisory
- This medicine contains a combination of 2 drugs Dicyclomine and Simethicone.
- Each of these drugs treats a different disease or symptom.
- Treating different diseases with different medicines allows doctors to adjust the dose of each medicine separately. This prevents overmedication or undermedication.
- Most doctors advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
Summary
Dicyclomine is used to treat irritable bowel syndrome, which is a condition that causes abdominal pain and muscle spasms in the gastrointestinal tract. Simethicone is used to relieve symptoms of excessive gas, such as bloating and discomfort. Both medications help alleviate gastrointestinal distress, but Dicyclomine specifically targets muscle spasms, while Simethicone focuses on gas relief.
Dicyclomine works by blocking the action of acetylcholine, which is a neurotransmitter that causes muscle contractions, thereby relaxing the muscles in the gastrointestinal tract and relieving spasms. Simethicone acts as an anti-foaming agent, which means it reduces the surface tension of gas bubbles in the gut, allowing them to combine and be expelled more easily. Both medications target gastrointestinal discomfort but through different mechanisms: Dicyclomine as a muscle relaxant and Simethicone as a gas reducer.
Dicyclomine is usually taken orally, with a typical adult dose of 20 mg four times a day, which can be increased to 40 mg four times a day if needed and tolerated. Simethicone is also taken orally, typically in doses of 40-125 mg after meals and at bedtime, as needed, to relieve symptoms of gas. Both medications are taken by mouth and can be adjusted based on individual patient needs.
Common side effects of Dicyclomine include dry mouth, dizziness, blurred vision, and drowsiness. Serious adverse effects can include confusion, hallucinations, and difficulty breathing. Simethicone is generally well-tolerated, with few reported side effects, though some may experience mild gastrointestinal discomfort. Dicyclomine has a higher risk of side effects due to its anticholinergic properties, while Simethicone is considered safer with minimal adverse effects.
Dicyclomine is contraindicated in patients with glaucoma, which is a condition that increases pressure in the eye, myasthenia gravis, which is a neuromuscular disease, and severe ulcerative colitis, which is a chronic inflammatory bowel disease, due to its anticholinergic effects. It should be used with caution in elderly patients and those with cardiovascular conditions. Simethicone has no major contraindications but should be used as directed. Dicyclomine's anticholinergic properties necessitate more caution compared to Simethicone.
Indications and Purpose
How does combination of Dicyclomine and Simethicone work?
Dicyclomine works by blocking the action of acetylcholine, a neurotransmitter that causes muscle contractions, thereby relaxing the muscles in the gastrointestinal tract and relieving spasms. Simethicone acts as an anti-foaming agent, reducing the surface tension of gas bubbles in the gut, allowing them to combine and be expelled more easily. Both medications target gastrointestinal discomfort but through different mechanisms: Dicyclomine as a muscle relaxant and Simethicone as a gas reducer.
How effective is combination of Dicyclomine and Simethicone?
Clinical trials have shown that Dicyclomine is effective in reducing symptoms of irritable bowel syndrome, with a significant number of patients experiencing relief from abdominal pain and spasms. Simethicone's effectiveness is supported by its ability to reduce gas-related symptoms, as it helps break down gas bubbles in the digestive tract. Both medications have been proven to improve gastrointestinal comfort, though they work through different mechanisms: Dicyclomine as an anticholinergic and Simethicone as an anti-foaming agent.
Directions for Use
What is the usual dose of combination of Dicyclomine and Simethicone?
The usual adult daily dose for Dicyclomine is 20 mg taken four times a day, which can be increased to 40 mg four times a day if needed and tolerated. Simethicone is typically taken in doses of 40-125 mg after meals and at bedtime, as needed, to relieve symptoms of gas. Both medications are used to treat gastrointestinal issues, but Dicyclomine is specifically for irritable bowel syndrome, while Simethicone is for gas relief. They are both taken orally and can be adjusted based on individual patient needs.
How does one take combination of Dicyclomine and Simethicone?
Dicyclomine should be taken as directed by a healthcare provider, usually four times a day, and can be taken with or without food. Patients should avoid alcohol as it can increase drowsiness. Simethicone is typically taken after meals and at bedtime to relieve gas symptoms. There are no specific food restrictions for Simethicone, but it is important to follow the dosing instructions. Both medications should be taken as prescribed, and patients should consult their healthcare provider for any specific dietary advice.
For how long is combination of Dicyclomine and Simethicone taken?
Dicyclomine is typically used for short-term relief of irritable bowel syndrome symptoms, with treatment duration often limited to two weeks if no improvement is seen. Simethicone can be used as needed for gas relief, with no specific duration of use, as it is generally considered safe for longer-term use. Both medications are used to manage gastrointestinal symptoms, but Dicyclomine's use is more restricted due to potential side effects, while Simethicone can be used more flexibly.
How long does it take for combination of Dicyclomine and Simethicone to work?
Dicyclomine typically starts working within 60-90 minutes after oral administration. It is absorbed quickly and distributed throughout the body, providing relief from muscle spasms in the gastrointestinal tract. Simethicone, on the other hand, works by breaking up gas bubbles in the gut, providing relief from bloating and discomfort. The onset of action for Simethicone is usually within a few minutes to an hour. Both medications are used to alleviate symptoms related to gastrointestinal discomfort, but they work through different mechanisms: Dicyclomine as an anticholinergic and Simethicone as an anti-foaming agent.
Warnings and Precautions
Are there harms and risks from taking combination of Dicyclomine and Simethicone?
Common side effects of Dicyclomine include dry mouth, dizziness, blurred vision, and drowsiness. Serious adverse effects can include confusion, hallucinations, and difficulty breathing. Simethicone is generally well-tolerated, with few reported side effects, though some may experience mild gastrointestinal discomfort. Both medications aim to relieve gastrointestinal symptoms, but Dicyclomine has a higher risk of side effects due to its anticholinergic properties, while Simethicone is considered safer with minimal adverse effects.
Can I take combination of Dicyclomine and Simethicone with other prescription drugs?
Dicyclomine can interact with other anticholinergic drugs, increasing the risk of side effects like dry mouth and blurred vision. It may also interact with medications that affect the central nervous system, such as sedatives and antidepressants. Simethicone has minimal drug interactions, making it safe to use with most medications. Both medications should be used with caution, and patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.
Can I take combination of Dicyclomine and Simethicone if I am pregnant?
Dicyclomine should be used during pregnancy only if clearly needed, as there are no well-controlled studies in pregnant women. However, animal studies have not shown harm to the fetus. Simethicone is generally considered safe during pregnancy, as it is not absorbed into the bloodstream. Both medications should be used under medical supervision during pregnancy, with Dicyclomine requiring more caution due to its potential effects on the fetus.
Can I take combination of Dicyclomine and Simethicone while breastfeeding?
Dicyclomine is contraindicated during breastfeeding as it is excreted in breast milk and may cause serious adverse effects in infants, such as respiratory issues. Simethicone is generally considered safe during breastfeeding, as it is not absorbed into the bloodstream and thus not excreted in breast milk. Both medications require consideration of the risks and benefits, but Dicyclomine poses a higher risk to nursing infants compared to Simethicone.
Who should avoid taking combination of Dicyclomine and Simethicone?
Dicyclomine is contraindicated in patients with glaucoma, myasthenia gravis, and severe ulcerative colitis due to its anticholinergic effects. It should be used with caution in elderly patients and those with cardiovascular conditions. Simethicone has no major contraindications but should be used as directed. Both medications require careful use in specific populations, and patients should inform their healthcare provider of their medical history to avoid potential risks. Dicyclomine's anticholinergic properties necessitate more caution compared to Simethicone.
