Diazepam

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Drug Status

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Government Approvals

US(FDA), UK(BNF)

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WHO Essential Medicine

YES

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Known Teratogen

NO

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Pharmaceutical Class

Benzodiazepine

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Controlled Drug Substance

YES

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Drug Ingredient

Diazepam

Summary

  • Diazepam is used to treat conditions like anxiety disorders, muscle spasms, seizures, and alcohol withdrawal symptoms. It can also be used as an adjunct treatment for epilepsy.

  • Diazepam works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA), which helps calm the brain and nervous system. This results in a sedative, anxiolytic, and anticonvulsant effect, helping to relax muscles and reduce nervous activity.

  • For anxiety, the usual dose is 2-10 mg taken 2-4 times per day. For muscle spasms, the dose can range from 2-10 mg taken 3-4 times daily. For seizures, doses depend on the severity but typically start at 2-10 mg. Diazepam can be taken orally in tablet form or as a liquid.

  • Common side effects of diazepam include drowsiness, fatigue, muscle weakness, and poor coordination. In severe cases, it can lead to confusion, paranoia, suicidal thoughts, seizures, and trouble breathing.

  • Diazepam can be habit-forming, so it should be used with caution. It may cause drowsiness or dizziness, so avoid driving or operating heavy machinery until you know how the medication affects you. People with severe breathing problems or liver disease should not take Diazepam.

Indications and Purpose

How does Diazepam work?

Diazepam works by increasing the activity of GABA, a neurotransmitter in the brain that helps inhibit nerve activity. This reduces the effects of anxiety, muscle spasms, and seizures, producing a calming effect.

How does one know if Diazepam is working?

The benefit of Diazepam is usually checked or evaluated by monitoring your symptoms and your response to the medication. Your doctor may ask you to keep track of your symptoms, such as anxiety or insomnia, and to report any changes in your condition.

Is Diazepam effective?

Studies show that Diazepam is effective for its approved uses. Clinical trials confirm its anxiolytic properties, significantly reducing anxiety levels in patients. It has demonstrated effectiveness in treating muscle spasms, seizures, and alcohol withdrawal symptoms. Research also supports its sedative properties for preoperative anxiety. Its rapid onset and reliable action in these conditions reinforce its therapeutic efficacy.

What is Diazepam?

Diazepam is a medication used to treat anxiety, muscle spasms, and seizures. It can also help with alcohol withdrawal symptoms. Diazepam is a controlled substance because it can be misused or abused. Common side effects of diazepam include drowsiness, fatigue, muscle weakness, and poor coordination. Diazepam should be stored in a cool, dry place.

What is Diazepam used for?

Diazepam is commonly indicated for the following conditions:

  1. Anxiety disorders and short-term relief of anxiety.
  2. Muscle spasms due to various conditions.
  3. Seizure disorders, including as an adjunct treatment for epilepsy.
  4. Alcohol withdrawal symptoms, to reduce agitation and prevent seizures.
  5. Sedation before medical procedures, for its calming and relaxing effects.

Directions for Use

For how long do I take Diazepam?

The duration of treatment with diazepam varies depending on the condition being treated. For acute anxiety or muscle spasms, treatment is usually short-term. If you're using it for long-term conditions like seizure management, it may be required for an extended period.

How do I take Diazepam?

Diazepam can be taken orally in tablet form or as a liquid. It should be taken with or without food as prescribed by your doctor. Make sure to follow your doctor’s instructions carefully regarding dosing.

How long does it take for Diazepam to start working?

Diazepam works quickly, often within 15–60 minutes, to provide relief from anxiety, muscle spasms, and seizures. The effect can last several hours, depending on the dose and condition being treated.

How should I store Diazepam?

Diazepam should usually be kept at room temperature, around 77°F. However, it can be stored between 59°F and 86°F for short periods.

What is the usual dose of Diazepam?

The usual dose for anxiety is 2-10 mg, taken 2-4 times per day. For muscle spasms, the dose can range from 2-10 mg, taken 3-4 times daily. For seizures, doses depend on the severity but typically start at 2-10 mg. Children receive smaller doses.

Warnings and Precautions

Can Diazepam be taken safely while breastfeeding?

Diazepam is generally not recommended for use during lactation and breastfeeding due to the potential for the medication to pass into breast milk and cause side effects in the nursing infant.

Can Diazepam be taken safely while pregnant?

Taking Diazepam during pregnancy requires close supervision. While studies suggest that benzodiazepines may not increase the risk of major birth defects, using them late in pregnancy may lead to breathing problems or sluggishness in newborns. Additionally, babies may experience withdrawal symptoms, such as jitteriness or irritability. There's a registry that tracks outcomes for women who used Diazepam during pregnancy. The average risk of birth defects and miscarriage is 2-4% and 15-20%, respectively. Breastfeeding is not recommended as Diazepam can pass into breast milk, causing sedation or withdrawal in infants.

Can I take Diazepam with other prescription drugs?

There are several significant prescription drug interactions that people using Diazepam should be aware of. These include:

Sedatives: Taking Diazepam with other sedatives, such as opioids or antihistamines, can increase the sedative effects of these medications, which can lead to drowsiness, dizziness, or even coma.

Antidepressants: Taking Diazepam with certain antidepressants can increase the risk of side effects, such as drowsiness or confusion.

Can I take Diazepam with vitamins or supplements?

Mixing Diazepam with other medications, including vitamins and supplements, can be dangerous. It's essential to consult a doctor before starting or stopping any concurrent medications, as interactions can cause side effects or interfere with the effectiveness of Diazepam or other medications.

Is Diazepam safe for the elderly?

For older adults, it's important to start with a low dose of diazepam (2 mg to 2.5 mg once or twice a day) and gradually increase it as needed and tolerated. This helps prevent dizziness or drowsiness. Diazepam and its metabolite can build up in the body over time, especially if you have kidney problems, which are common in older adults. So, it's crucial to monitor kidney function and adjust the dose carefully. Older adults are more likely to experience unusual reactions to diazepam, so it's important to be cautious and monitor closely.

Is it safe to drink alcohol while taking Diazepam?

Don't mix alcohol and Diazepam Oral Solution. They can make you feel too sleepy or dizzy. Talk to your doctor before using them together.

Is it safe to exercise while taking Diazepam?

Exercise is generally safe while taking diazepam, but be cautious. If you feel drowsy or dizzy, it’s better to rest until the effects wear off. Always listen to your body and adjust your activity level if needed.

Who should avoid taking Diazepam?

Diazepam is a medication that can be abused and misused, leading to addiction and potentially overdose or death. It should not be mixed with other medications, alcohol, or illegal drugs. Combining it with opioids can cause serious breathing problems and drowsiness. It's important to be cautious when using machinery or driving after taking it. People with breathing issues or weakness should take lower doses. Pregnant women should be aware that it can cause sedation or withdrawal symptoms in their babies. Breastfeeding is not recommended. Rarely, it can cause thoughts of suicide.