Cyclizine + Dipipanone
Find more information about this combination medication at the webpages for Cyclizine
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Advisory
- This medicine contains a combination of 2 drugs: Cyclizine and Dipipanone.
- Based on evidence, Cyclizine and Dipipanone are more effective when taken together.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
Summary
Cyclizine is used to prevent and treat nausea and vomiting, which are feelings of sickness and the act of throwing up, often caused by motion sickness or after surgery. Dipipanone is used to relieve moderate to severe pain, which refers to discomfort that can range from mild to intense. Both medicines help improve comfort by managing symptoms that affect daily life.
Cyclizine works by blocking histamine H1 receptors, which are parts of the body that respond to allergens, and has anticholinergic properties, which help reduce nausea by affecting the brain's vomiting center. Dipipanone works as an opioid analgesic, which means it binds to opioid receptors in the brain to change how pain is felt. Both act on the central nervous system, which is the body's control center, to relieve symptoms.
The usual dose for the combination of Cyclizine and Dipipanone is one tablet every 6 hours as needed for pain relief. Each tablet typically contains 10 mg of Dipipanone and 30 mg of Cyclizine. These medicines are taken by mouth, which means they are swallowed. It's important to follow the dosing instructions provided by a healthcare professional to avoid side effects or dependency, which is a reliance on the drug.
Common side effects of Cyclizine include drowsiness, which is feeling sleepy, dry mouth, which is a lack of saliva, and dizziness, which is feeling unsteady. Dipipanone can cause constipation, which is difficulty in passing stools, nausea, and drowsiness. Both medicines can cause drowsiness and dizziness, so it's important to be cautious when using them. Dipipanone also carries a risk of dependence, which is a need to keep taking the drug.
Cyclizine should not be used by people allergic to its ingredients and should be used carefully in those with glaucoma, which is increased pressure in the eye, or heart problems. Dipipanone should not be used by people with breathing problems and should be used carefully in those with a history of substance abuse, which is misuse of drugs. Both should not be mixed with alcohol or other drugs that affect the brain, as this can increase drowsiness.
Indications and Purpose
How does combination of Cyclizine and Dipipanone work?
Cyclizine works by blocking histamine H1 receptors and has anticholinergic properties, which help prevent nausea and vomiting by reducing the sensitivity of the inner ear and inhibiting the emetic center in the brain. Dipipanone acts as an opioid analgesic, binding to opioid receptors in the central nervous system to alter the perception of pain. Both medicines act on the central nervous system, but Cyclizine focuses on antiemetic effects while Dipipanone provides analgesic effects. The shared mechanism involves modulation of central nervous system pathways to alleviate symptoms.
How effective is combination of Cyclizine and Dipipanone?
Cyclizine's effectiveness is supported by its ability to block histamine H1 receptors and reduce nausea and vomiting, with clinical use in motion sickness and post-operative care. Dipipanone's efficacy is demonstrated through its action on opioid receptors, providing significant pain relief. Both medicines have been used in clinical settings to manage symptoms effectively, with Cyclizine focusing on antiemetic effects and Dipipanone on analgesic effects. The shared evidence of effectiveness is their ability to improve patient comfort and quality of life by addressing specific symptoms.
Directions for Use
What is the usual dose of combination of Cyclizine and Dipipanone?
The usual dose of the combination of Cyclizine and Dipipanone is typically one tablet every 6 hours as needed for pain relief. Each tablet usually contains 10 mg of Dipipanone and 30 mg of Cyclizine. It's important to follow the specific dosing instructions provided by a healthcare professional or the information on the medication packaging. This combination is used to manage moderate to severe pain and should be taken exactly as prescribed to avoid potential side effects or dependency.
How does one take combination of Cyclizine and Dipipanone?
Cyclizine can be taken with or without food, but taking it with food may help reduce stomach upset. Dipipanone should be taken as directed by a healthcare provider, and it may also be taken with food to minimize gastrointestinal discomfort. There are no specific food restrictions for either medicine, but alcohol should be avoided as it can increase the sedative effects of both drugs. The shared instruction is the option to take with food to enhance tolerance and the caution against alcohol consumption.
For how long is combination of Cyclizine and Dipipanone taken?
Cyclizine is typically used for short-term relief of nausea and vomiting, with its effects lasting about 4 to 6 hours per dose. Dipipanone, as an opioid, is also intended for short-term use due to the risk of dependence and side effects. Both medicines are generally not recommended for long-term use, emphasizing the importance of addressing the underlying cause of symptoms. The shared attribute is their suitability for acute symptom management rather than chronic use.
How long does it take for combination of Cyclizine and Dipipanone to work?
Cyclizine, when taken orally, begins to work within 30 minutes, with its effects peaking between 1 to 2 hours and lasting for about 4 to 6 hours. This rapid onset is due to its absorption from the gastrointestinal tract. Dipipanone, an opioid analgesic, typically starts to relieve pain within 30 to 60 minutes after oral administration. Both medicines are designed to act quickly to address symptoms, with Cyclizine targeting nausea and vomiting, and Dipipanone providing pain relief. The shared attribute of both medicines is their relatively fast onset of action, making them effective for acute symptom management.
Warnings and Precautions
Are there harms and risks from taking combination of Cyclizine and Dipipanone?
Common side effects of Cyclizine include drowsiness, dry mouth, and dizziness. Significant adverse effects can include blurred vision, tachycardia, and urinary retention. Dipipanone, as an opioid, can cause side effects such as constipation, nausea, and drowsiness, with significant risks including respiratory depression and dependence. Both medicines share common side effects like drowsiness and dizziness, and both require careful monitoring to avoid serious adverse effects. The unique risks of Dipipanone include opioid-related issues like dependence, while Cyclizine's anticholinergic effects can lead to specific side effects like dry mouth.
Can I take combination of Cyclizine and Dipipanone with other prescription drugs?
Cyclizine can interact with alcohol and other central nervous system depressants, enhancing their sedative effects. It may also interact with anticholinergic drugs, increasing side effects. Dipipanone, as an opioid, can have significant interactions with other CNS depressants, increasing the risk of respiratory depression. Both medicines share the risk of enhanced sedation when combined with other CNS depressants, and both require careful monitoring when used with other medications that affect the central nervous system. The unique concern for Dipipanone is its potential for opioid-related interactions.
Can I take combination of Cyclizine and Dipipanone if I am pregnant?
The use of Cyclizine during pregnancy is not advised due to the absence of definitive human data. Dipipanone, as an opioid, should be used with caution during pregnancy due to potential risks to the fetus, including respiratory depression and withdrawal symptoms. Both medicines require careful consideration of the risks and benefits when used during pregnancy. The shared attribute is the need for caution and consultation with a healthcare provider to ensure the safety of both the mother and the developing fetus.
Can I take combination of Cyclizine and Dipipanone while breastfeeding?
Cyclizine is excreted in human milk, but the amount is not quantified, so caution is advised when used during breastfeeding. Dipipanone, as an opioid, can also be excreted in breast milk and may affect the nursing infant, potentially causing sedation or respiratory issues. Both medicines should be used with caution during lactation, and healthcare providers should weigh the benefits against potential risks to the infant. The shared concern is the potential for adverse effects on the breastfeeding infant, necessitating careful consideration and consultation with a healthcare provider.
Who should avoid taking combination of Cyclizine and Dipipanone?
Cyclizine is contraindicated in individuals with hypersensitivity to its components and should be used cautiously in patients with glaucoma, urinary retention, and severe heart conditions. Dipipanone, as an opioid, is contraindicated in patients with respiratory depression and should be used with caution in those with a history of substance abuse. Both medicines should not be combined with alcohol or other CNS depressants due to increased sedation risk. The shared warnings include the potential for CNS depression and the need for careful use in patients with specific health conditions.
