Clonazepam
Myoclonic Epilepsies, Bipolar Disorder ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Benzodiazepine
Controlled Drug Substance
YES
Clonazepam
Learn more about this medicine -
Click HereSummary
Clonazepam is used to treat seizure disorders such as epilepsy in both adults and children. It can also be used to treat panic disorder with or without fear of open spaces, known as agoraphobia, in adults.
Clonazepam works by increasing the levels of GABA, a neurotransmitter that calms down brain activity. This results in reduced anxiety and seizure activity.
Clonazepam is typically taken orally, with or without food, 1 to 3 times a day. The starting dose is usually 0.5 mg to 1 mg once a day, which can be gradually increased by 0.5 mg to 1 mg every 3 days until the desired effect is achieved. The maximum recommended daily dose is 4 mg.
Common side effects of Clonazepam include drowsiness and dizziness. Serious adverse effects can include seizures and suicidal thoughts.
Clonazepam should not be taken by pregnant women or breastfeeding mothers unless the benefits outweigh the risks. It can cause allergic reactions, dependence and withdrawal symptoms if stopped suddenly. It can also increase the risk of suicidal thoughts, especially in patients with a history of depression or suicidal behavior.
Indications and Purpose
What is Clonazepam used for?
Clonazepam is indicated for the treatment of certain types of seizures, including absence seizures and myoclonic seizures, as well as panic disorder with or without agoraphobia. It helps manage symptoms by calming abnormal brain activity.
How does Clonazepam work?
Clonazepam enhances the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits abnormal brain activity. This action helps reduce anxiety, prevent seizures, and stabilize mood by calming the nervous system.
Is Clonazepam effective?
Clonazepam's effectiveness in treating panic disorder and certain types of seizures has been demonstrated in clinical trials. It works by enhancing the activity of GABA, an inhibitory neurotransmitter in the brain, which helps reduce abnormal electrical activity.
How does one know if Clonazepam is working?
The benefit of Clonazepam is evaluated through regular medical check-ups and monitoring of symptoms. Your doctor may order lab tests to assess your response to the medication and adjust the dosage as needed to ensure effectiveness and minimize side effects.
Directions for Use
What is the usual dose of Clonazepam?
For adults with seizure disorders, the initial dose should not exceed 1.5 mg/day divided into three doses. The maintenance dose usually ranges from 4 to 8 mg/day. For children, the initial dose should not exceed 0.25 mg/day for infants and small children (1 to 5 years) and 0.5 mg/day for older children. The maintenance dose for infants is 0.5 to 1 mg/day, for small children 1 to 3 mg/day, and for school children 3 to 6 mg/day.
How do I take Clonazepam?
Clonazepam can be taken with or without food. Take it at the same time each day as directed by your doctor. Avoid alcohol and discuss with your doctor any dietary restrictions, such as grapefruit, which may interact with the medication.
For how long do I take Clonazepam?
Clonazepam is often used for short-term treatment due to the risk of dependence and withdrawal symptoms. The duration of use should be determined by a healthcare provider based on the individual's condition and response to treatment. Long-term use requires regular evaluation of the drug's effectiveness and necessity.
How long does it take for Clonazepam to start working?
Clonazepam is rapidly absorbed, and its effects can be felt within 1 to 4 hours after oral administration. However, it may take a few weeks to feel the full benefits, especially for conditions like panic disorder.
How should I store Clonazepam?
Store Clonazepam in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and dispose of unneeded medication through a take-back program to prevent accidental ingestion.
Warnings and Precautions
Who should avoid taking Clonazepam?
Clonazepam can cause drowsiness, respiratory depression, and dependence. Avoid alcohol and other CNS depressants. It's contraindicated in patients with severe liver disease, acute narrow-angle glaucoma, and those with a history of substance abuse. Consult your doctor for personalized advice.
Can I take Clonazepam with other prescription drugs?
Clonazepam can interact with opioids, increasing the risk of severe sedation and respiratory depression. It may also interact with other CNS depressants, anticonvulsants, and certain antidepressants. Always inform your doctor about all medications you are taking to avoid harmful interactions.
Can I take Clonazepam with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Clonazepam be taken safely while pregnant?
Clonazepam should be used during pregnancy only if the potential benefits outweigh the risks. It may cause fetal harm, including withdrawal symptoms in newborns. Pregnant women should consult their doctor and consider enrolling in a pregnancy registry to monitor outcomes.
Can Clonazepam be taken safely while breastfeeding?
Clonazepam can pass into breast milk and may cause sedation and feeding problems in infants. Breastfeeding mothers should consult their doctor to weigh the benefits and risks. Monitoring the infant for sedation and poor feeding is recommended if Clonazepam use is necessary.
Is Clonazepam safe for the elderly?
Elderly patients should use Clonazepam with caution, starting at lower doses due to increased sensitivity to side effects like drowsiness and confusion. Regular monitoring is essential to adjust the dosage and ensure safety. Consult a healthcare provider for personalized advice.
Is it safe to exercise while taking Clonazepam?
Clonazepam can cause drowsiness, dizziness, and muscle weakness, which may affect your ability to exercise safely. If you experience these side effects, it is advisable to avoid strenuous activities and consult your doctor for guidance on managing these symptoms while maintaining an exercise routine.
Is it safe to drink alcohol while taking Clonazepam?
Drinking alcohol while taking Clonazepam can increase the risk of severe side effects, including drowsiness, dizziness, and difficulty breathing. Alcohol can also enhance the sedative effects of Clonazepam, leading to potentially dangerous situations. It is advised to avoid alcohol consumption during treatment with Clonazepam.
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