Cinacalcet
Secondary Hyperparathyroidism, Primary Hyperparathyroidism ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Calcium-sensing Receptor Agonist
Controlled Drug Substance
No
cinacalcet
Summary
Cinacalcet is used to treat secondary hyperparathyroidism, which is a condition where the parathyroid glands produce too much hormone, in patients with chronic kidney disease. It also treats hypercalcemia, which is high calcium levels in the blood, in patients with parathyroid cancer.
Cinacalcet works by mimicking calcium in the body, which helps lower parathyroid hormone levels. This action reduces calcium levels in the blood, helping manage conditions like secondary hyperparathyroidism and hypercalcemia.
The usual starting dose of Cinacalcet for adults is 30 mg once daily. Your doctor may adjust your dose based on your response and blood test results. The maximum recommended dose is 180 mg per day. Always follow your doctor's specific dosing instructions for your personal health needs.
Common side effects of Cinacalcet include nausea, vomiting, and diarrhea. These effects vary from person to person. If you notice new symptoms after starting Cinacalcet, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Cinacalcet can lower calcium levels in your blood, which can cause muscle spasms, tingling, or seizures. If you experience these symptoms, seek medical help immediately. Regular blood tests are needed to monitor calcium levels. Not adhering to these warnings can lead to serious health issues.
Indications and Purpose
How does Cinacalcet work?
Cinacalcet works by mimicking calcium in the body, which helps lower parathyroid hormone levels. This action reduces calcium levels in the blood. Think of it like a thermostat that adjusts the "temperature" of calcium in your body. This helps manage conditions like secondary hyperparathyroidism and hypercalcemia.
Is Cinacalcet effective?
Cinacalcet is effective in treating conditions like secondary hyperparathyroidism in patients with chronic kidney disease and hypercalcemia in patients with parathyroid cancer. It works by lowering parathyroid hormone levels, which helps control calcium levels in the blood. Clinical studies support its effectiveness in managing these conditions.
What is Cinacalcet?
Cinacalcet is a medication used to treat conditions like secondary hyperparathyroidism and hypercalcemia. It belongs to a class of drugs called calcimimetics, which work by lowering parathyroid hormone levels, helping control calcium levels in the blood. It's used in patients with chronic kidney disease and parathyroid cancer.
Directions for Use
For how long do I take Cinacalcet?
Cinacalcet is usually a long-term medication for managing conditions like secondary hyperparathyroidism and hypercalcemia. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your treatment.
How do I dispose of Cinacalcet?
Bring unused Cinacalcet to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This helps prevent harm to people and the environment.
How do I take Cinacalcet?
Take Cinacalcet as prescribed by your doctor, usually once daily. It's best to take it with food or shortly after a meal to help your body absorb it better. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Avoid taking two doses at once.
How long does it take for Cinacalcet to start working?
Cinacalcet begins working shortly after you take it, but it may take several weeks to see the full therapeutic effect. The time it takes to work can depend on your condition and overall health. Regular blood tests will help monitor its effectiveness. Take it exactly as prescribed for the best results.
How should I store Cinacalcet?
Store Cinacalcet at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep it out of reach of children to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Cinacalcet?
The usual starting dose of Cinacalcet for adults is 30 mg once daily. Your doctor may adjust your dose based on your response and blood test results. The maximum recommended dose is 180 mg per day. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Cinacalcet be taken safely while breastfeeding?
The safety of Cinacalcet while breastfeeding is not well-established. It's unclear if the medication passes into breast milk. Discuss with your doctor whether to continue breastfeeding or use Cinacalcet, considering the benefits and potential risks to the infant. Your doctor can help you make an informed decision.
Can Cinacalcet be taken safely while pregnant?
The safety of Cinacalcet during pregnancy is not well-established. Limited data is available, so it's important to weigh the benefits and risks with your doctor. If you're pregnant or planning to become pregnant, discuss the safest treatment options for your condition with your healthcare provider.
Can I take Cinacalcet with other prescription drugs?
Cinacalcet can interact with certain medications, such as ketoconazole, which can increase its levels in your blood. This may increase the risk of side effects. Other drugs, like calcium supplements, can reduce its effectiveness. Always inform your doctor about all medications you're taking to manage potential interactions.
Does Cinacalcet have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Cinacalcet include nausea and vomiting. Serious side effects can include low calcium levels, which may cause muscle spasms or seizures. If you notice any new or worsening symptoms, contact your doctor immediately. Regular monitoring can help manage these effects.
Does Cinacalcet have any safety warnings?
Yes, Cinacalcet has important safety warnings. It can lower calcium levels in your blood, which can cause muscle spasms, tingling, or seizures. If you experience these symptoms, seek medical help immediately. Regular blood tests are needed to monitor calcium levels. Not adhering to these warnings can lead to serious health issues.
Is Cinacalcet addictive?
Cinacalcet is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by affecting calcium levels in your body, not brain chemistry, so it doesn't lead to addiction. If you have concerns about medication dependence, you can feel confident that Cinacalcet doesn't carry this risk.
Is Cinacalcet safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Cinacalcet, such as low calcium levels, which can lead to muscle spasms or seizures. Regular monitoring of calcium levels is important. Discuss with your doctor the risks and benefits of using Cinacalcet if you are elderly.
Is it safe to drink alcohol while taking Cinacalcet?
It's best to avoid alcohol while taking Cinacalcet. Alcohol can interfere with the medication's effectiveness and may worsen side effects like nausea. If you choose to drink, limit your alcohol intake and monitor for any adverse reactions. Talk with your doctor about alcohol use while taking Cinacalcet for personalized advice.
Is it safe to exercise while taking Cinacalcet?
You can exercise while taking Cinacalcet, but be cautious. The medication can cause low calcium levels, leading to muscle spasms or weakness. Stay hydrated and avoid strenuous activities if you experience these symptoms. Most people can maintain their regular exercise routine, but consult your doctor if you have concerns.
Is it safe to stop Cinacalcet?
Stopping Cinacalcet suddenly can cause your calcium levels to rise, which may worsen your condition. Always talk with your doctor before stopping Cinacalcet. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
What are the most common side effects of Cinacalcet?
Side effects are unwanted reactions to a medication. Common side effects of Cinacalcet include nausea, vomiting, and diarrhea. These effects vary from person to person. If you notice new symptoms after starting Cinacalcet, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Cinacalcet?
Don't take Cinacalcet if you have low blood calcium levels, as it can worsen this condition. This is an absolute contraindication. Use caution if you have liver problems, as this is a relative contraindication. Always consult your doctor about these concerns before starting Cinacalcet.
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