Cabergoline
Parkinson Disease, Adenoma ... show more
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Ergot Derivative
Controlled Drug Substance
NO
Cabergoline
Learn more about this medicine -
Click HereSummary
Cabergoline is used to treat hyperprolactinemia, a condition characterized by high levels of prolactin hormone. This can lead to symptoms like irregular periods, infertility, and unwanted breast milk production. It may also be used in low doses for Parkinson's disease.
Cabergoline works by mimicking a brain chemical called dopamine. It stimulates dopamine D2 receptors in the hypothalamus, inhibiting the release of prolactin from the anterior pituitary gland. This reduces prolactin levels in the blood, alleviating symptoms caused by its overproduction.
The initial dose for adults is typically 0.25 mg taken orally twice a week. Dose adjustments are made every 4 weeks based on prolactin levels, with a maximum recommended dose of 1 mg twice weekly.
Common side effects include nausea, headache, dizziness, and fatigue. Serious but rare side effects include heart valve disorders, shortness of breath, or fibrosis affecting the lungs or heart.
Cabergoline is contraindicated in individuals with uncontrolled hypertension, heart valve disorders, or a history of fibrotic conditions. It should also be avoided by those allergic to ergot derivatives or those with pregnancy-related hypertension unless benefits outweigh risks.
Indications and Purpose
How does Cabergoline work?
Cabergoline works by stimulating dopamine D2 receptors in the hypothalamus, which inhibits the release of prolactin from the anterior pituitary gland. This decreases prolactin levels in the blood, alleviating symptoms caused by its overproduction.
How does one know if Cabergoline is working?
The effectiveness of Cabergoline is monitored through blood tests to measure prolactin levels. Symptom relief, such as the resumption of regular menstrual cycles or reduction in breast milk production, also indicates that the medication is working effectively
Is Cabergoline effective?
Yes, Cabergoline is highly effective in treating hyperprolactinemia. Studies show that it normalizes prolactin levels in 77–95% of patients, often outperforming alternatives like bromocriptine. It also improves related symptoms, such as restored menstrual cycles, reduced galactorrhea, and improved fertility.
What is Cabergoline?
Cabergoline is a medication that works by mimicking a natural brain chemical called dopamine. High levels of another hormone, prolactin, can cause problems like infertility and sexual difficulties. Cabergoline lowers prolactin levels.A common side effect is dizziness when you stand up suddenly. This is usually mild and goes away as your body adjusts.
What is Cabergoline used for?
Cabergoline is used to treat hyperprolactinemia, which may be caused by conditions like pituitary adenomas or idiopathic factors. It helps normalize prolactin levels, addressing symptoms like irregular periods, infertility, and galactorrhea (breast milk production not related to breastfeeding). It may also be prescribed in low doses for Parkinson’s disease.
Directions for Use
For how long do I take Cabergoline?
The duration of treatment depends on individual response and prolactin levels. Cabergoline can often be discontinued after maintaining normal prolactin levels for at least six months. Regular follow-ups and blood tests are necessary to determine if treatment needs to be restarted.
How do I take Cabergoline?
Cabergoline should be taken orally, with or without food, as directed by your doctor. It’s important to follow the prescribed schedule exactly and not take more or less than recommended. If you experience nausea, taking the medication with food may help reduce stomach discomfort.
How long does it take for Cabergoline to start working?
Cabergoline usually starts lowering prolactin levels within 48 hours of the first dose. The full effect may take a few weeks as the body adjusts to the medication, but symptom improvement can often be noticed within the first month of use.
How should I store Cabergoline?
Store Cabergoline tablets at room temperature (20–25°C) in their original container, away from moisture and heat. Keep them out of reach of children and dispose of unused medication properly, preferably through a take-back program.
What is the usual dose of Cabergoline?
The initial dose for adults is typically 0.25 mg taken twice a week, with dose adjustments every 4 weeks based on prolactin levels. The maximum recommended dose is 1 mg twice weekly. Cabergoline’s safety and effectiveness in children have not been established, so it is not commonly prescribed for pediatric use.
Warnings and Precautions
Can Cabergoline be taken safely while breastfeeding?
Cabergoline is not recommended for breastfeeding mothers as it inhibits prolactin, a hormone necessary for milk production. Women planning to breastfeed should discuss alternative treatments with their doctor.
Can Cabergoline be taken safely while pregnant?
Cabergoline is generally avoided during pregnancy unless absolutely necessary. There is limited data on its safety in pregnant women, so the risks and benefits must be carefully assessed by your doctor. If you become pregnant while on Cabergoline, notify your doctor immediately.
Can I take Cabergoline with other prescription drugs?
Cabergoline should not be taken with dopamine antagonists like metoclopramide, as these can reduce its effectiveness. Always inform your doctor about all medications you’re using to avoid interactions and to ensure safe, effective treatment.
Can I take Cabergoline with vitamins or supplements?
While Cabergoline doesn’t have major interactions with most vitamins or supplements, it’s always important to inform your doctor about all the supplements you’re taking. This ensures proper monitoring and avoids any unforeseen interactions.
Is Cabergoline safe for the elderly?
Cabergoline can be safely used in elderly patients, but caution is advised due to potential age-related health conditions like reduced liver, kidney, or heart function. Doctors typically start elderly patients on lower doses and monitor them closely for side effects.
Is it safe to drink alcohol while taking Cabergoline?
Drinking alcohol moderately is generally safe but may increase the likelihood of dizziness or drowsiness. It’s advisable to limit alcohol intake and consult your doctor if you experience any adverse effects while combining alcohol with Cabergoline.
Is it safe to exercise while taking Cabergoline?
Exercise is generally safe while taking Cabergoline. If you experience side effects like dizziness, fatigue, or shortness of breath, reduce the intensity of your workout and speak with your doctor if symptoms persist.
Who should avoid taking Cabergoline?
Cabergoline is contraindicated in individuals with uncontrolled hypertension, heart valve disorders, or a history of fibrotic conditions (e.g., lung or cardiac fibrosis). It should also be avoided by those allergic to ergot derivatives or those with pregnancy-related hypertension unless benefits outweigh risks.
Forms / Brands
