Bempedoic Acid
Atherosclerosis, Hyperlipoproteinemia Type II
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Adenosine Triphosphate-Citrate Lyase Inhibitor
Controlled Drug Substance
No
bempedoic acid
Summary
Bempedoic Acid is used to lower LDL cholesterol, which is often called "bad" cholesterol. It helps reduce cholesterol levels in adults, especially when other treatments haven't worked well enough. By lowering cholesterol, it decreases the risk of heart disease and related complications.
Bempedoic Acid works by inhibiting an enzyme called ATP-citrate lyase, which is involved in cholesterol production in the liver. This reduces the liver's ability to produce cholesterol, leading to lower levels of LDL cholesterol in the blood.
The usual starting dose of Bempedoic Acid for adults is 180 mg once daily. It is typically taken as a pill, with or without food, at any time of the day. Swallow the tablet whole without crushing or chewing it.
Common side effects of Bempedoic Acid include muscle spasms, back pain, and increased uric acid levels, which can lead to gout, a type of arthritis causing joint pain. These effects are generally mild and may improve over time.
Bempedoic Acid may increase uric acid levels, leading to gout, and can increase the risk of tendon rupture, especially in older adults. It should not be used by those allergic to it or with severe liver disease. Always consult your doctor before starting this medication.
Indications and Purpose
How does Bempedoic Acid work?
Bempedoic Acid works by inhibiting an enzyme called ATP-citrate lyase, which is involved in cholesterol production in the liver. Think of it like turning down the volume on a radio; it reduces the liver's ability to produce cholesterol. This leads to lower levels of LDL cholesterol in the blood. By lowering cholesterol, Bempedoic Acid helps reduce the risk of heart disease and related complications.
Is Bempedoic Acid effective?
Bempedoic Acid is effective in lowering LDL cholesterol, which is often called "bad" cholesterol. It works by inhibiting an enzyme involved in cholesterol production in the liver. Clinical studies show that Bempedoic Acid significantly reduces LDL cholesterol levels in people with high cholesterol, especially when used with other cholesterol-lowering medications. This helps reduce the risk of heart disease and related complications.
What is Bempedoic Acid?
Bempedoic Acid is a medication used to lower LDL cholesterol, which is often called "bad" cholesterol. It belongs to a class of drugs called ATP-citrate lyase inhibitors, which work by reducing cholesterol production in the liver. Bempedoic Acid is primarily used to treat high cholesterol in adults, especially when other treatments haven't worked well enough. It is often used in combination with other cholesterol-lowering medications.
Directions for Use
For how long do I take Bempedoic Acid?
Bempedoic Acid is usually a long-term medication for managing high cholesterol. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your cholesterol levels to rise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your treatment.
How do I dispose of Bempedoic Acid?
To dispose of Bempedoic Acid, take it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away. This helps prevent accidental ingestion.
How do I take Bempedoic Acid?
Bempedoic Acid is usually taken as a once-daily pill. You can take it with or without food, at any time of the day. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions.
How long does it take for Bempedoic Acid to start working?
Bempedoic Acid begins working in your body shortly after you start taking it, but it may take several weeks to see significant changes in your cholesterol levels. The full therapeutic effect is usually achieved after a few months of consistent use. Individual factors like your overall health and adherence to the medication can affect how quickly you notice results. Regular blood tests will help monitor your progress.
How should I store Bempedoic Acid?
Store Bempedoic Acid at room temperature, between 68°F to 77°F, in a tightly closed container to protect it from moisture and light. Avoid storing it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Keep it out of children's reach to prevent accidental ingestion. Regularly check the expiration date and properly dispose of any unused or expired medication.
What is the usual dose of Bempedoic Acid?
The usual starting dose of Bempedoic Acid for adults is 180 mg once daily. This medication is typically taken with or without food. There is no need for dose adjustments based on age or kidney function, but always follow your doctor's specific dosing instructions. If you have any concerns about your dose, discuss them with your healthcare provider.
Warnings and Precautions
Can Bempedoic Acid be taken safely while breastfeeding?
Bempedoic Acid is not recommended while breastfeeding. There is limited information on whether this medication passes into human breast milk. To avoid potential risks to the baby, it's best to discuss alternative treatments with your doctor if you are breastfeeding. Your doctor can help you find a safer medication option that allows you to nurse your baby safely.
Can Bempedoic Acid be taken safely while pregnant?
Bempedoic Acid is not recommended during pregnancy. There is limited information on its safety in pregnant women, and it may pose risks to the developing baby. If you are pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your cholesterol. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Bempedoic Acid with other prescription drugs?
Bempedoic Acid can interact with certain medications, increasing the risk of side effects. For example, it may increase the risk of tendon rupture when taken with fluoroquinolone antibiotics. It can also raise uric acid levels, so caution is needed if you're taking medications that affect uric acid. Always inform your doctor about all the medications you take to avoid potential interactions and ensure safe treatment.
Does Bempedoic Acid have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Bempedoic Acid include muscle spasms, back pain, and increased uric acid levels. These effects are generally mild. A serious but rare adverse effect is tendon rupture. If you experience severe side effects or new symptoms, contact your doctor immediately. Always inform your healthcare provider about any adverse effects you experience.
Does Bempedoic Acid have any safety warnings?
Bempedoic Acid has important safety warnings. It may increase uric acid levels, which can lead to gout, a type of arthritis that causes sudden pain and swelling in joints. It can also increase the risk of tendon rupture, especially in older adults. If you experience joint pain, swelling, or sudden pain in your tendons, contact your doctor immediately. Always follow your doctor's advice and report any unusual symptoms.
Is Bempedoic Acid addictive?
Bempedoic Acid is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by affecting cholesterol levels in your body and doesn't impact brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Bempedoic Acid safe for the elderly?
Elderly individuals can use Bempedoic Acid, but they may be more vulnerable to side effects like increased uric acid levels, which can lead to gout. They may also have a higher risk of tendon rupture. It's important for elderly patients to have regular check-ups with their doctor to monitor for any adverse effects. Always follow your doctor's advice and report any unusual symptoms.
Is it safe to drink alcohol while taking Bempedoic Acid?
It's best to limit alcohol consumption while taking Bempedoic Acid. Alcohol can increase uric acid levels, which may lead to gout, a type of arthritis that causes sudden pain and swelling in joints. Drinking alcohol may also increase the risk of liver problems. If you choose to drink, do so in moderation and discuss your alcohol use with your doctor for personalized advice.
Is it safe to exercise while taking Bempedoic Acid?
You can exercise while taking Bempedoic Acid, but be aware of potential side effects like muscle spasms or joint pain. These might affect your exercise capacity. If you experience any discomfort during physical activity, slow down or stop and rest. Stay hydrated and avoid strenuous activities if you notice any symptoms. Most people can maintain their regular exercise routine, but consult your doctor if you have concerns.
Is it safe to stop Bempedoic Acid?
Bempedoic Acid is usually taken long-term for managing cholesterol levels. Stopping it suddenly may cause your cholesterol levels to rise, increasing the risk of heart disease. Always talk with your doctor before stopping Bempedoic Acid. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
What are the most common side effects of Bempedoic Acid?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Bempedoic Acid include muscle spasms, back pain, and increased uric acid levels. These side effects are generally mild and may improve over time. If you notice new symptoms after starting Bempedoic Acid, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Bempedoic Acid?
Bempedoic Acid should not be used if you are allergic to it or any of its ingredients. It is also contraindicated in people with severe liver disease. Use caution if you have a history of tendon disorders or gout, as Bempedoic Acid can increase uric acid levels. Always consult your doctor about any concerns or conditions you have before starting this medication.
