Aprocitentan
Hypertension
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Aprocitentan
Summary
Aprocitentan is used to treat high blood pressure in adults when other medications have not been effective enough.
Aprocitentan works by blocking the action of a substance called endothelin, which causes blood vessels to narrow. This helps relax the blood vessels, reducing blood pressure and easing the heart's workload.
The usual dose for adults is 12.5 mg of Aprocitentan taken orally, once daily.
Common side effects of Aprocitentan include fluid retention, anemia, and headache. Serious effects include liver toxicity, fluid retention, and decrease in hemoglobin.
Aprocitentan is not recommended during pregnancy due to the risk of serious birth defects. It should also not be used by women of childbearing potential who are not using reliable contraception. It is contraindicated in patients with severe liver impairment and those allergic to its ingredients.
Indications and Purpose
How does Aprocitentan work?
Aprocitentan works by affecting specific pathways in the body to help manage certain health conditions. It belongs to a class of medications that target these pathways to produce therapeutic effects. Think of it like adjusting the settings on a machine to improve its function. Aprocitentan helps regulate processes in the body to achieve better health outcomes. Your doctor can provide more detailed information on how it works for your specific condition.
Is Aprocitentan effective?
Aprocitentan is effective for its approved uses, which include managing certain health conditions. Clinical studies support its effectiveness in improving health outcomes for these conditions. Your doctor will monitor your progress to ensure the medication is working as intended. If you have any concerns about the effectiveness of Aprocitentan, discuss them with your healthcare provider.
What is Aprocitentan?
Aprocitentan is a medication used to treat certain health conditions. It belongs to a class of drugs that work by affecting specific pathways in the body. Aprocitentan is primarily indicated for managing conditions like hypertension, which is high blood pressure. It may also have secondary uses as determined by your doctor. Always follow your healthcare provider's instructions when taking Aprocitentan.
Directions for Use
For how long do I take Aprocitentan?
Aprocitentan is usually taken long-term for managing chronic conditions. The duration of use depends on your health needs and how your body responds to the medication. Always follow your doctor's instructions regarding how long to take Aprocitentan. If you have any questions or concerns about the duration of your treatment, discuss them with your healthcare provider.
How do I dispose of Aprocitentan?
To dispose of Aprocitentan, take it to a drug take-back program or collection site at a pharmacy or hospital. If that's not possible, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. This helps prevent harm to people and the environment.
How do I take Aprocitentan?
Take Aprocitentan exactly as your doctor prescribes. It's usually taken once daily, and you can take it with or without food. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions regarding food, beverages, and any other medications you are taking.
How long does it take for Aprocitentan to start working?
Aprocitentan begins working shortly after you take it, but the full therapeutic effect may take some time to achieve. The time it takes to notice improvements can vary based on individual factors like your health condition and how your body responds to the medication. Follow your doctor's instructions and attend regular check-ups to monitor your progress. If you have concerns about how quickly Aprocitentan is working, discuss them with your healthcare provider.
How should I store Aprocitentan?
Store Aprocitentan at room temperature, away from moisture and light. Keep it in a tightly closed container. Avoid storing it in humid places like bathrooms. If the packaging isn't child-resistant, transfer it to a container that children can't easily open. Always keep Aprocitentan out of children's reach. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Aprocitentan?
The usual starting dose of Aprocitentan for adults is determined by your doctor based on your specific health needs. It's typically taken once daily. Your doctor may adjust your dose depending on how you respond to the medication. Always follow your doctor's dosing instructions carefully. If you have any questions about your dose or how to take Aprocitentan, consult your healthcare provider.
Warnings and Precautions
Can Aprocitentan be taken safely while breastfeeding?
The safety of Aprocitentan while breastfeeding is not well-established. It's unclear if the medication passes into breast milk or affects milk supply. If you're breastfeeding or planning to breastfeed, discuss the risks and benefits of Aprocitentan with your doctor. They can help determine the best treatment plan for you and your baby, considering your health needs and the safety of your child.
Can Aprocitentan be taken safely while pregnant?
The safety of Aprocitentan during pregnancy is not well-established. Limited evidence makes it difficult to provide definitive advice. If you're pregnant or planning to become pregnant, talk with your doctor about the risks and benefits of using Aprocitentan. They can help create a treatment plan that considers your health needs and the safety of your baby.
Can I take Aprocitentan with other prescription drugs?
Aprocitentan may interact with drugs that are substrates of OAT3, potentially increasing their plasma concentrations. Caution is advised when co-administering with drugs that have a narrow therapeutic index. Aprocitentan is also a substrate and inhibitor of UGT1A1 and UGT2B7, and it may affect the pharmacokinetics of other drugs metabolized by these enzymes.
Does Aprocitentan have adverse effects?
Adverse effects are unwanted reactions to a medication. Aprocitentan may cause some adverse effects, but most people tolerate it well. Common adverse effects include dizziness and fatigue. Serious side effects are rare but can occur. If you experience any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to Aprocitentan and advise on the best course of action.
Does Aprocitentan have any safety warnings?
Yes, Aprocitentan has safety warnings. It's important to follow your doctor's instructions and the prescription information. Not adhering to safety warnings can lead to serious health consequences. If you experience any unusual symptoms or side effects, contact your healthcare provider immediately. They can provide guidance on how to manage any issues and ensure your treatment remains safe and effective.
Is Aprocitentan addictive?
Aprocitentan is not considered addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. This medication works by affecting certain pathways in the body, but it does not impact brain chemistry in a way that leads to addiction. If you have concerns about medication dependence, discuss them with your doctor, who can provide reassurance and guidance.
Is Aprocitentan safe for the elderly?
Elderly patients may have a higher risk of experiencing side effects such as edema/fluid retention, heart failure, and anemia. It is recommended to monitor these patients closely for signs of fluid retention or heart failure. No dose adjustment is required for patients over the age of 65.
Is it safe to drink alcohol while taking Aprocitentan?
It's best to avoid alcohol while taking Aprocitentan. Alcohol can interfere with the medication and increase the risk of side effects like dizziness or low blood pressure. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while taking Aprocitentan to get personalized advice based on your health situation.
Is it safe to exercise while taking Aprocitentan?
You can exercise while taking Aprocitentan, but be mindful of potential side effects like dizziness or low blood pressure. These might affect your exercise capacity. To exercise safely, drink plenty of water and watch for signs of dizziness or fatigue. If you notice these symptoms, slow down or stop exercising and rest. Consult your doctor if you have concerns about exercising while on Aprocitentan.
Is it safe to stop Aprocitentan?
It's important not to stop taking Aprocitentan without consulting your doctor. This medication is usually prescribed for long-term use to manage chronic conditions. Stopping it suddenly can worsen your condition or cause other health issues. Your doctor can guide you on how to safely stop or adjust your medication if needed. Always follow your healthcare provider's advice to ensure your treatment remains effective.
What are the most common side effects of Aprocitentan?
Side effects are unwanted reactions to a medication. Common side effects of Aprocitentan include dizziness and fatigue. These effects vary from person to person. If you notice new symptoms after starting Aprocitentan, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication. They can help determine if the side effects are related to Aprocitentan and suggest ways to manage them.
Who should avoid taking Aprocitentan?
Aprocitentan should not be used if you have certain conditions, such as severe liver or kidney problems. These are considered absolute contraindications. Relative contraindications require caution, and the drug may be used if benefits outweigh risks. Always inform your doctor about your medical history and any other medications you are taking. They can determine if Aprocitentan is safe for you.
