Triglynase 2mg/500mg/15mg Tablet SR

Introduction

Triglynase 2mg/500mg/15mg Tablet SR is prescribed medications used in the management of type 2 diabetes mellitus. It is a combination of three medications Glimepiride, Metformin and Pioglitazone.

Each of these drugs contributes to diabetes control in different ways.

Glimepiride: This belongs to the sulfonylurea class and stimulates the release of insulin from the pancreas It helps lower blood sugar levels by increasing the amount of insulin produced by the body.

Metformin: This is a biguanide that improves insulin sensitivity, reducing the amount of glucose produced by the liver and enhancing the body's response to insulin It also helps lower blood sugar levels.

Pioglitazone: A thiazolidinedione, it works by improving insulin sensitivity in the body's cells, allowing them to better respond to insulin This results in lower blood sugar levels.

Follow the prescribed dosage provided by your healthcare provider. This medication often comes in a fixed dose combination, and the number of tablets to be taken may vary.

It is usually taken with meals to help reduce the risk of stomach upset. 

Some common side effects with this medication combination The blood sugar lowering effect may lead to hypoglycaemia, manifesting as shakiness, dizziness, sweating, and confusion. Gastrointestinal issues such as nausea, diarrhoea, or abdominal discomfort may occur. Additionally, some individuals might experience fluctuations in weight.

Due to the potential impact on the kidneys, those taking Metformin may undergo regular kidney function tests. Similarly, periodic liver function tests may be recommended because of potential effects on the liver.

If a dose is inadvertently missed, prompt action is necessary. Take the missed dose as soon as you remember, unless the next scheduled dose is imminent. In such cases, it's advisable to skip the missed dose to avoid doubling up.

How it works

Glimepiride, a sulfonylurea, stimulates insulin release from the pancreas, aiding in blood glucose reduction. Metformin, a biguanide, targets hepatic glucose production and enhances peripheral insulin sensitivity. Pioglitazone, a thiazolidinedione, improves insulin sensitivity in adipose tissue and skeletal muscle. Together, these medications act synergistically to regulate insulin secretion, reduce hepatic glucose output, and enhance peripheral glucose utilization. This combination offers an effective strategy for managing diabetes by addressing multiple facets of glucose homeostasis.

How to take

["Follow your doctor's guidance for this medicine, taking it in the prescribed dose and duration","You can take this medicine with or without food, but maintaining a consistent time daily is recommended for better results","Swallow the drug whole; avoid chewing, crushing, or breaking it"]

Adverse drug effect

--Hypoglycemia, Gastrointestinal disturbances, Metallic taste, Rash, Weight gain, Upper respiratory tract infection, Fracture, Bladder cancer

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