restem (ZOLPIDEM)
Introduction to Restem
Restem is a medication primarily used to treat insomnia, a condition where individuals have trouble falling or staying asleep. It is designed for short-term use to help improve s... See More

What is Restem?
Restem is a medication commonly used to treat insomnia, particularly for short-term management of sleep initiation difficulties. It works by enhancing the activity of GABA (gamma-aminobutyric acid) in the brain, a neurotransmitter that has calming effects on the central nervous system. By binding to specific GABA receptors, Restem helps promote sleepiness and reduces the time it takes to fall asleep. It is typically used as a short-term solution due to the risk of dependency with long-term use.

What is the usual dose of Restem?
- For adults, women should start with 5 mg and men with 5 or 10 mg each night before bed. - Do not take more than 10 mg per day. - Restem is not recommended for children.

How do I take Restem?
Restem should be taken on an empty stomach, ideally just before bedtime. It is important to avoid taking it with food, as food can delay its absorption and may reduce its effectiveness. People using Restem should also avoid alcohol and other central nervous system depressants (like sedatives, tranquilizers, or antidepressants) while taking the medication, as combining these substances can enhance the sedative effects and increase the risk of side effects such as excessive drowsiness or difficulty breathing.

For how long do I take Restem?
Restem is a sleep aid that should only be used for a short time, like a few weeks. If you take it for longer, you may become dependent on it and it may no longer work as well. You may also be more likely to misuse or become addicted to it. That's why it's important to talk to your doctor if you need to take Restem for more than a few weeks.

What is Restem used for?
Restem is primarily indicated for the short-term treatment of insomnia. It is used to help individuals who have difficulty falling asleep or staying asleep. It may be prescribed for sleep initiation and, in some cases, for sleep maintenance. Restem is typically intended for short-term use (generally 2 to 4 weeks) due to the risk of dependence and tolerance.

How long does it take for Restem to start working?
Restem typically starts working within 15 to 30 minutes after ingestion. Its peak effect is usually felt within 1 to 2 hours. The onset of action can vary depending on individual factors like metabolism and whether the medication is taken on an empty stomach.

Is Restem effective?
Clinical studies demonstrate that Restem significantly reduces sleep onset latency and improves sleep quality. It has been shown to help patients fall asleep faster and stay asleep longer, with effects occurring within 15 to 30 minutes. Compared to placebo, Restem is proven to enhance sleep efficiency and reduce nighttime awakenings, making it effective for short-term insomnia treatment.

How does one know if Restem is working?
The benefit of Restem is evaluated through clinical assessments of sleep patterns, typically using sleep diaries or actigraphy. Sleep onset time, total sleep duration, and sleep quality are measured. Patient-reported outcomes, such as the Insomnia Severity Index or quality of life questionnaires, are also used to assess the medication’s effectiveness in improving sleep.

How does Restem work?
Restem works by binding to GABA receptors in the brain, specifically the GABA-A receptors. GABA (gamma-aminobutyric acid) is a neurotransmitter that has an inhibitory effect on the nervous system, promoting relaxation and sleep. By enhancing the effects of GABA, Restem helps induce sleep, reduce the time it takes to fall asleep, and improve sleep quality. Unlike traditional benzodiazepines, Restem is more selective in its action, focusing on the sleep-related areas of the brain, which helps minimize some of the side effects associated with other sedative medications.

Who should avoid taking Restem?
Restem should not be used by individuals with a history of hypersensitivity to the drug, sleep apnea, or severe liver impairment. It can cause impaired coordination and memory issues, so caution is needed when operating machinery or driving. It should not be combined with alcohol or other sedatives, as it increases the risk of severe side effects.

Can I take Restem with vitamins or supplements?
Restem may interact with supplements that have sedative effects, such as valerian root, kava, or melatonin, increasing the risk of excessive sedation. It's important to avoid combining Restem with these supplements unless advised by a healthcare provider. Additionally, certain supplements like St. John's Wort may reduce Restem's effectiveness. Always consult a doctor before combining medications or supplements.

Can I take Restem with other prescription drugs?
Restem can interact with other central nervous system depressants, such as alcohol, benzodiazepines, opioids, and antihistamines, increasing the risk of sedation, respiratory depression, and overdose. It may also interact with certain antidepressants (SSRIs, SNRIs) and anticonvulsants, enhancing side effects. Always inform a healthcare provider of all medications being taken to avoid harmful interactions.

Can Restem be taken safely while pregnant?
Restem is classified as a Category C medication during pregnancy, meaning animal studies have shown adverse effects, but there are no adequate human studies. It may cause harm to the fetus, especially during the first trimester. It should only be used if the benefits outweigh the risks, and under the guidance of a healthcare provider.

Can Restem be taken safely while breastfeeding?
Restem is excreted in breast milk in small amounts. While short-term use may be considered safe, it is recommended to use it with caution while breastfeeding. To avoid potential sedation or side effects in the infant, a healthcare provider may suggest alternatives or monitor the baby closely for any adverse reactions.

Is Restem safe for the elderly?
Restem is not recommended for older adults because: * The 7.5 mg dose is too strong and cannot be adjusted as needed. * Older adults are more sensitive to sedatives and may experience drowsiness, dizziness, and difficulty thinking. * Doses above 5 mg can disrupt sleep the following night. * Older adults are more likely to have falls and confusion, especially if they take more than the recommended dose.

How should I store Restem?
The ideal storage temperature for this item is between 20°C to 25°C (68°F to 77°F). However, temporary excursions between 15°C and 30°C (59°F to 86°F) are acceptable.

Does Restem make people tired or drowsy?
Yes, Restem is a sleep medication that can cause drowsiness or tiredness. It’s designed to help people fall asleep, but the drowsiness can linger. If you feel overly tired the next day, avoid activities like driving, and consult your doctor if the sleepiness is bothersome or lasts too long.

Does Restem cause stomach upset?
Stomach upset such as nausea or abdominal discomfort may occur with Restem, but it’s relatively uncommon. If you feel unwell, try taking the medication with food. If symptoms persist or worsen, it’s a good idea to speak with your doctor.

Does Restem affect sleep?
Restem is used to treat insomnia and generally helps people sleep. However, it might cause unusual effects like nightmares, sleepwalking, or waking up feeling groggy. If you notice any disturbances in your sleep or behavior, contact your healthcare provider.

Does Restem make it hard to think or concentrate?
Restem may cause memory problems, trouble thinking, or difficulty concentrating, especially when used long-term or in high doses. If you notice these cognitive issues, avoid activities that require focus and consult your doctor to see if a dosage adjustment is necessary.

Does Restem affect mood?
Restem may cause memory problems, trouble thinking, or difficulty concentrating, especially when used long-term or in high doses. If you notice these cognitive issues, avoid activities that require focus and consult your doctor to see if a dosage adjustment is necessary.

Does Restem interfere with sexual function?
Some users may experience sexual side effects, such as reduced libido or difficulty reaching orgasm. While not very common, it’s important to inform your doctor if you notice changes in your sexual health while taking Restem.

Does Restem affect appetite?
Restem rarely affects appetite, but some people might experience changes in hunger levels. If you experience a noticeable change in appetite or eating habits, discuss it with your doctor, especially if it's impacting your health or well-being.

Does Restem cause weight gain?
Weight gain isn’t a common side effect of Restem. However, if you experience changes in weight, either gain or loss, discuss this with your doctor to ensure the medication isn't affecting your metabolism or causing other issues.

Does Restem cause headaches?
Headaches are a common side effect of Restem, occurring in a minority of people. If you suffer from frequent headaches, drinking water or taking over-the-counter pain relievers might help. Contact your doctor if the headaches become persistent.

Does Restem limit driving?
Yes, Restem can impair coordination and drowsiness, which may affect your ability to drive or perform tasks that require alertness. Always avoid driving after taking Restem and consult with your doctor if you have concerns about your ability to drive safely.

Is it safe to drink alcohol while taking Restem?
No, combining Restem with alcohol can be dangerous. Both substances have sedative effects, which may enhance drowsiness, dizziness, and respiratory problems. This combination can increase the risk of serious side effects. Avoid alcohol while taking Restem, and talk to your doctor for more guidance.

Is it safe to drink coffee or tea while taking Restem?
Caffeine can potentially reduce the effectiveness of Restem because it may counteract its calming effects. If you consume caffeinated beverages, it’s best to avoid doing so close to taking Restem. Talk to your doctor for personalized advice based on your situation.

Is it safe to exercise while taking Restem?
Exercising while taking Restem may be safe if you feel alert and coordinated. However, since Restem can cause drowsiness and coordination problems, it's important to avoid strenuous physical activity or exercise requiring balance until you know how the medication affects you. Always check with your doctor first.

What are Restem possible harms and risks?
Common side effects of Restem include dizziness, headache, drowsiness, and gastrointestinal discomfort. Serious adverse effects may include memory problems, sleepwalking, abnormal behavior, and allergic reactions. In rare cases, it can lead to confusion, depression, or suicidal thoughts. It is essential to monitor for these effects and consult a doctor if any occur.
Available in 2 variations

Restem 10mg Tablet 10s
Zolpidem (10mg)
strip of 10 tablets

Restem 5mg Tablet
Restem 5mg Tablet
Zolpidem (5mg)
strip of 10 tablets