Placidin 400mg Tablet XR can be taken with or without food However it is recommended to take it at the same time every day to maintain a consistent level of the medicine in your body Follow the dosage and duration as prescribed by your doctor and if you happen to miss a dose take it as soon as you remember Do not abruptly stop taking this medication without consulting your doctor as it may worsen your symptoms However if you experience symptoms like fever muscle rigidity altered consciousness or seizures discontinue the medicine immediately as this could be a sign of neuroleptic malignant syndrome NMS Some common side effects of this medicine include headache dry mouth and constipation In the beginning this medication may cause a sudden drop in blood pressure when changing positions so it is advisable to rise slowly if you have been sitting or lying down It may also cause dizziness and drowsiness so refrain from driving or engaging in activities that require mental focus until you understand how this medicine affects you This medication may lead to weight gain but incorporating a healthy diet and regular exercise into your lifestyle can help minimize this side effect Be cautious while using this medicine as it may increase the risk of developing diabetes It is recommended to regularly monitor your glucose levels Inform your doctor if you experience any unusual changes in mood or behavior new or worsening depression or thoughts of suicide while taking this medicine