To avoid an upset stomach it is recommended to take P D N Drop with food Swallow the medication whole with water at the same time each day Your doctor will determine the appropriate dosage and frequency of administration which may be adjusted over time depending on its effectiveness It is important to take this medicine regularly for maximum benefits even if you feel well Common side effects of P D N Drop include reduced bone density weight gain mood changes upset stomach and changes in behavior If these side effects bother you or persist it is advisable to discuss them with your doctor Taking P D N Drop may also weaken your immune system making it more difficult to fight off infections If you experience symptoms such as fever or a sore throat inform your doctor Make sure to inform your doctor about any preexisting medical conditions particularly poor blood circulation diabetes and immune system problems Additionally disclose any other medications you are currently taking especially steroids