Lenta 4mg Capsule 10s (LENVATINIB)

What is Lenta capsule?

Lenta capsule is commonly used to treat thyroid cancer, kidney cancer, and liver cancer. It works by inhibiting specific proteins called tyrosine kinases, which are involved in the growth of cancer cells and the development of blood vessels that feed tumors. By blocking these pathways, Lenta capsule slows tumor growth and helps limit the spread of cancer.

What is the usual dose of Lenta capsule?

The usual starting dose for adults is typically 50 mg taken once daily. Depending on the individual's response, the dose may be adjusted by a healthcare provider. The maximum recommended dose is usually 100 mg per day. For secondary indications, such as treating high blood pressure, the dose might differ, and a healthcare provider will provide specific instructions. For special populations like children or the elderly, dose adjustments are often necessary to ensure safety and effectiveness. It's crucial to follow a healthcare provider's instructions for dosing to avoid any potential side effects or complications.

How do I take Lenta capsule?

Lenta capsule can be taken with or without food, depending on personal preference or medical advice. Swallow the capsules whole with water; do not crush or chew them. Maintain a consistent schedule, taking it at the same time daily. Avoid grapefruit or grapefruit juice during treatment, as it may interfere with how the medicine works. Always follow your doctor’s specific instructions.

For how long do I take Lenta capsule?

The duration of Lenta capsule treatment depends on the condition being treated and individual patient response. It is typically continued until:

• The cancer progresses (becomes resistant to the treatment).
• The patient experiences unacceptable side effects.

For some cancers, like hepatocellular carcinoma or thyroid cancer, treatment can last several months to years. The exact duration should always be determined by the treating oncologist based on regular monitoring and evaluation.

What disease or symptom is Lenta capsule used for?

Lenta capsule is used to treat certain cancers, including thyroid cancer resistant to radioactive iodine, advanced kidney cancer (with pembrolizumab), liver cancer unsuitable for surgery, and advanced endometrial cancer (with pembrolizumab). It works by blocking specific proteins that promote cancer growth and by disrupting the tumor's blood supply, helping to slow disease progression.

How long does it take for Lenta capsule to start working?

The time it takes for Lenta capsule to start working can vary depending on the individual and the type of cancer being treated. Generally, patients may notice clinical improvements, such as reduced tumor growth, within a few weeks to a couple of months of starting treatment. Regular monitoring through imaging and medical assessments helps evaluate its effectiveness over time.

Is Lenta capsule effective?

Evidence for Lenta capsule's effectiveness comes from clinical trials such as SELECT (thyroid cancer), REFLECT (liver cancer), and CLEAR (kidney and endometrial cancers). These studies showed that Lenta capsule significantly improves progression-free survival and overall response rates compared to standard treatments. Its combination with pembrolizumab also demonstrated enhanced outcomes in advanced kidney and endometrial cancers, supporting its role in targeted cancer therapy.

How do I know if Lenta capsule is working?

The benefit of Lenta capsule is primarily evaluated through clinical endpoints such as progression-free survival (PFS), overall survival (OS), objective response rate (ORR), and the duration of response (DoR). These outcomes are monitored in clinical trials to assess how well the drug slows disease progression, shrinks tumors, and improves survival in patients with various cancers. Regular imaging (CT, MRI) and biomarker testing are used to track these indicators.

How does Lenta capsule work?

Lenta capsule is a targeted therapy that works by inhibiting specific receptor tyrosine kinases (RTKs), including VEGFR, FGFR, PDGFR, RET, and KIT. These proteins are involved in tumor growth, angiogenesis (formation of new blood vessels), and cancer cell survival. By blocking these pathways, Lenta capsule reduces blood supply to tumors and slows cancer progression.

Who should avoid taking Lenta capsule?

Most people tolerate Telmisartan well, and difficulty thinking or concentrating is not commonly reported. If you experience cognitive issues, ensure you get enough rest and consult your healthcare provider if symptoms persist.

Can I take Lenta capsule with other prescription drugs?

Lenta capsule can interact with medications that affect liver enzymes, such as CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) or inducers (e.g., rifampin), altering its effectiveness. It may also interact with other cancer treatments, anticoagulants (like warfarin), and antihypertensive drugs, increasing the risk of bleeding or affecting blood pressure. Always inform your doctor of all medications being taken.

Can Lenta capsule be taken safely while pregnant?

Lenta capsule is not recommended during pregnancy due to the potential for fetal harm. Animal studies have shown adverse effects on fetal development, including malformations and fetal death. It is classified as a Category D drug, meaning there is evidence of risk to the fetus. Women should avoid pregnancy while using Lenta capsule and discuss contraception options with their doctor.

Can Lenta capsule be taken safely while breastfeeding?

Lenta capsule is not recommended during breastfeeding due to the potential risk to the infant. It is unknown whether Lenta capsule passes into breast milk, but given its potential for serious adverse effects, it is advised to avoid breastfeeding during treatment. Women should consult their healthcare provider to discuss alternatives or the timing of breastfeeding.

Is Lenta capsule safe for the elderly?

Lenvima has been shown to be safe and effective for patients over 65, but those over 75 may experience reduced tolerance to the medication. It is important to inform your doctor about any surgeries you are planning and to maintain good oral hygiene while taking Lenvima.

How should I store Lenta capsule?

Lenta capsule should be stored at room temperature, away from moisture and heat, typically between 20°C to 25°C (68°F to 77°F). It should be kept in its original packaging, tightly closed to protect it from moisture. Ensure that it is out of reach of children. Do not store it in the bathroom, where humidity is high.

Does Lenta capsule make people tired or drowsy?

Fatigue is a commonly reported side effect of Lenta capsule, affecting around 30-60% of patients. While drowsiness or sleepiness is less common, you might still feel more tired than usual during treatment. This happens because the body is working harder to fight the cancer and process the medicine.

If you experience fatigue, listen to your body. Rest as needed and avoid overexertion. Staying hydrated, eating a balanced diet, and light exercises like walking may help boost your energy. If the fatigue is severe or disrupts your daily life, let your doctor know. They can adjust your dose or recommend strategies to manage it.

Avoid driving or using heavy machinery if you feel too tired or sleepy. Managing these side effects effectively can help you maintain a better quality of life during treatment.

Does Lenta capsule cause stomach upset?

Lenta capsule commonly causes nausea, vomiting, diarrhea, and abdominal pain, with diarrhea affecting up to 67% of patients. These side effects occur because the medicine affects your body’s systems while fighting cancer.

If you experience these symptoms, stay hydrated by drinking plenty of fluids like water or oral rehydration solutions. Eat smaller, bland meals to ease nausea and avoid foods that irritate your stomach. Over-the-counter medications for diarrhea or nausea may help, but check with your doctor first.

If these side effects persist, worsen, or cause weakness or dehydration, contact your healthcare provider immediately. They may adjust your dose or provide specific treatments to manage these symptoms. Prompt attention can help ensure you stay comfortable and continue with your treatment effectively.

Does Lenta capsule affect sleep?

Insomnia (difficulty sleeping) is a less common side effect of Lenta capsule, reported in about 7% of patients. It might occur due to the body’s reaction to the medication or the stress of treatment. Poor sleep can affect your energy and mood, so addressing it is important.

If you have trouble sleeping, try simple fixes like keeping a regular sleep schedule, avoiding caffeine late in the day, and creating a calm bedtime routine. Limit screen time before bed and ensure your bedroom is dark and comfortable.

If insomnia persists or worsens, talk to your doctor. They can recommend strategies, adjust your treatment, or prescribe medications if needed to help you rest better. Managing your sleep can improve how you feel during treatment and support your overall health.

Does Lenta capsule make it hard to think or concentrate?

Lenta capsule can sometimes cause difficulty concentrating or memory problems, though these cognitive side effects are not very common. Fatigue or dizziness, which are more frequently reported, can also indirectly affect your ability to focus.

If you notice trouble concentrating or remembering things while on Lenta capsule, start by giving yourself extra time to complete tasks and using tools like reminders or notes to stay organized. Rest well and avoid multitasking, as these can make it harder to focus.

If these symptoms significantly impact your daily life or worsen, inform your doctor. They can evaluate whether the medicine or another factor is causing the issue and adjust your treatment if necessary. Taking steps to address cognitive side effects can help you manage everyday activities more easily while staying on track with your treatment plan.

Does Lenta capsule affect mood?

Lenta capsule can sometimes affect mental health, causing anxiety, irritability, or mood changes, though these are not very common. These symptoms may arise as your body adjusts to the medication or from the stress of treatment.

If you feel more anxious, irritable, or notice mood changes, try relaxation techniques like deep breathing, meditation, or light exercise. Talking openly with loved ones or joining a support group can also help ease emotional strain.

It’s important to inform your doctor if these feelings persist, worsen, or interfere with your daily life. They can assess if Lenta capsule or another factor is causing these changes and adjust your treatment plan or recommend helpful therapies. Addressing mental health is a vital part of staying well during cancer treatment.

Does Lenta capsule interfere with sexual function?

Some medicines, like certain antidepressants, blood pressure meds, or those for erectile dysfunction, can affect sexual health. Common side effects include a decrease in libido (loss of interest in sex) or difficulty getting or keeping an erection. These side effects may happen to some, but not everyone experiences them. It's hard to say exactly how often they occur, as it depends on the specific medicine.

If you notice these changes while taking a medicine, it’s important to talk to your doctor. They can help adjust your treatment plan or suggest options to manage these effects. Don’t stop taking the medicine without a doctor's advice, as they will guide you in the best way to handle the issue. Communication is key to ensuring both your mental and physical health are taken care of.

Does Lenta capsule affect appetite?

Lenta capsule, a medication used to treat certain types of cancer, can affect eating behaviors. Some people may experience a decreased appetite, meaning they don’t feel as hungry or find it harder to eat, while others might have an increased appetite. These changes can happen but don't affect everyone, and the frequency varies from person to person.

If you notice changes in your appetite while taking Lenta capsule, it’s important to talk to your doctor. They may suggest ways to manage it, like adjusting your meal plan or offering solutions to deal with nausea, if that’s a factor. If you find eating too difficult, it’s important to share this with your doctor so they can offer support and check if there’s anything else going on. Keep eating regularly to maintain strength during your treatment.

Does Lenta capsule cause weight gain?

Lenta capsule, a medication used to treat cancer, can cause changes in weight, with weight loss being more commonly reported than weight gain. This can happen because Lenta capsule might reduce your appetite, cause nausea, or make it harder to maintain a healthy eating routine. However, not everyone will experience these effects, and they can vary from person to person.

If you notice a significant weight change while on Lenta capsule, it’s important to talk to your doctor. Unintended weight loss can be concerning, and your doctor can help manage it by recommending dietary adjustments, supplements, or other strategies to maintain your weight. If you’re gaining weight without an obvious reason, your doctor can also check for any underlying issues. Regularly monitoring your weight can help you and your doctor stay on top of any changes during treatment.

Does Lenta capsule cause headaches?

Lenta capsule can sometimes cause headaches as a side effect. It’s not something that happens to everyone, but some people may experience them. The exact frequency of headaches varies, but it's a known issue for some taking this medication.

If you get a headache while on Lenta capsule, first try simple things like resting in a quiet, dark room and drinking plenty of water. You can take over-the-counter pain relievers like paracetamol, but check with your doctor to make sure it's safe to do so alongside your treatment. If the headache is severe, persistent, or gets worse over time, let your doctor know immediately. They may adjust your medication or offer other ways to relieve the discomfort. Never ignore frequent or intense headaches, as they can signal something more serious. Regular check-ins with your doctor can help manage any side effects.

Does Lenta capsule limit driving?

Lenta capsule may cause side effects like dizziness, fatigue, or a general feeling of weakness, which could impact your ability to drive safely. While not everyone experiences these effects, it’s important to be cautious if you do.

If you feel lightheaded, unusually tired, or notice any difficulty concentrating or focusing, avoid driving until you feel better. Driving requires full attention, and if these side effects are present, it could be unsafe for both you and others on the road.

If you experience any of these symptoms regularly, talk to your doctor. They may adjust your treatment or suggest ways to manage these effects. It’s important not to ignore these concerns, as your safety should always come first. Always listen to your body and take necessary precautions to avoid driving when you don't feel fully alert.

Is it safe to drink alcohol while taking Lenta capsule?

Drinking alcohol while taking Lenta capsule is not recommended. Alcohol can interact with the medicine and may increase the risk of side effects, like liver problems, or make some side effects worse, such as dizziness or tiredness. It can also affect your immune system, which is important while undergoing cancer treatment.

Though an occasional or moderate drink might not seem to cause immediate harm, it’s better to avoid alcohol during your treatment to ensure that Lenta capsule works as effectively as possible and to reduce the risk of unexpected issues. Everyone reacts differently, so if you have questions about drinking while on this medication, talk to your doctor. They can provide personalized advice based on your treatment plan and health status. Your doctor’s guidance is key to managing both your medication and any lifestyle choices.

Is it safe to drink coffee or tea while taking Lenta capsule?

Drinking caffeinated beverages like coffee or tea generally doesn't interfere with the effectiveness of Lenta capsule. However, caffeine can sometimes make certain side effects, like dizziness or trouble sleeping, worse. Since Lenta capsule itself can cause side effects such as fatigue or lightheadedness, adding caffeine might make you feel more jittery or affect your rest.

If you find that caffeine is making side effects harder to manage, it’s best to limit your intake. Everyone reacts differently, so it's important to listen to your body. If you're unsure whether caffeine is affecting you or your treatment, it’s a good idea to talk to your doctor. They can help guide you on how to manage your caffeine consumption while on Lenta capsule, ensuring that you stay comfortable and get the best results from your treatment.

Is it safe to exercise while taking Lenta capsule?

Lenta capsule may affect your ability to exercise, both moderately or strenuously, because it can cause side effects like fatigue, weakness, or dizziness. These side effects may make physical activity more difficult, especially if you feel tired or lightheaded during your workout.

Moderate exercises, like walking or light stretching, may be manageable depending on how you’re feeling. However, more intense activities, such as running or heavy lifting, might be harder if you’re experiencing fatigue or weakness.

It’s important to listen to your body. If you feel like exercising is becoming too difficult or unsafe, talk to your doctor. They can suggest the best way to stay active while taking Lenta capsule. In some cases, they may recommend lighter exercises or adjustments to your treatment plan to help you stay comfortable and healthy during your treatment.

What are the most common side effects of Lenta capsule?

A side effect is an unwanted or unexpected symptom caused by a medicine. For this medicine, common side effects may include nausea, which is feeling sick to your stomach, dizziness, which is feeling lightheaded or unsteady, headache, which is pain in the head, fatigue, which is feeling very tired, and dry mouth, which is a lack of saliva. The frequency of these side effects can vary, but they are generally considered common. It's important to note that when starting a new medicine, people might experience new symptoms that could be unrelated to the medicine, temporary, or due to another health issue. Always talk to a healthcare provider before stopping any medicine, as they can provide guidance on managing side effects and ensure your treatment is safe and effective.

Does Lenta capsule have adverse effects?

Adverse effects, which are unwanted or harmful reactions to a medicine, can occur with any medication. For this medicine, common adverse effects might include nausea, headache, dizziness, fatigue, and dry mouth. These effects can vary in frequency, with some people experiencing them more often than others. Rare but serious adverse effects could include severe allergic reactions, which might cause difficulty breathing or swelling of the face and throat, and require immediate medical attention. It's crucial to report any new or worsening symptoms to a healthcare provider. Never stop taking a medicine without consulting a healthcare professional, as they can provide guidance on managing side effects or adjusting treatment if necessary.

Is Lenta capsule addictive?

This medicine does not have any known potential for dependence or addiction. It is considered safe in terms of habit-forming properties. Therefore, there is no need to worry about physical or psychological dependence when using this medication as prescribed. However, it is always important to follow the dosage instructions provided by your healthcare provider to ensure safe and effective use. If you have any concerns or experience any unusual symptoms, it is advisable to consult with your healthcare professional for further guidance.

Does Lenta capsule have any safety warnings?

This medicine has several safety warnings. First, it may cause drowsiness, which means it can make you feel sleepy or less alert. This is important because it can affect your ability to drive or operate machinery safely. If you feel unusually tired or have trouble concentrating, avoid these activities. Another warning is the risk of allergic reactions, which are the body's response to a substance it sees as harmful. Symptoms can include rash, itching, swelling, or difficulty breathing. If you notice any of these signs, seek medical help immediately. Lastly, this medicine can affect liver function, which refers to how well your liver works. Signs of liver issues include yellowing of the skin or eyes, dark urine, or severe stomach pain. If you experience these symptoms, contact your doctor right away.

Is it safe to stop Lenta capsule?

To determine if it's safe to stop a medicine, first identify its purpose. If it's for managing a chronic condition like hypertension or diabetes, stopping it suddenly can lead to serious health risks, such as uncontrolled blood pressure or blood sugar levels. If the medicine is for symptomatic relief or treating a temporary condition, like an infection, stopping it might lead to a return of symptoms or incomplete treatment. Some medicines can cause withdrawal or rebound symptoms if stopped abruptly, and others might have life-threatening risks. Always consult a doctor before stopping any medicine to ensure it's done safely and appropriately.

How do I dispose of Lenta capsule?

If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.

What are Lenta capsule possible harms and risks?

Common side effects of Lenta capsule include fatigue, high blood pressure, diarrhea, decreased appetite, nausea, weight loss, and mouth sores. Significant adverse effects may include liver toxicity, gastrointestinal bleeding, heart problems (e.g., heart failure), proteinuria (excess protein in urine), and severe bleeding or clotting issues. Patients should be monitored regularly for these potential complications.