klarim (CLARITHROMYCIN)

What is Klarim?

Klarim is a medicine that fights bacterial infections. It works by stopping bacteria from making proteins they need to survive. After taking a dose of Klarim, it takes about 3 hours for the medicine to reach its highest level in your body. It spreads into your tissues and fluids, where it can fight the infection. Klarim is not effective against viral infections.

How do I take Klarim?

**Klarim Oral Suspension:** * Can be taken with or without food or milk. **Klarim Extended-Release Tablets:** * Must be taken with food. **Other Food Restrictions:** * No other specific food restrictions are mentioned.

For how long do I take Klarim?

The typical duration of use for Klarim depends on the type and severity of the infection being treated. Generally:

• For respiratory infections (like pneumonia), the typical duration is 7 to 14 days.
• For skin infections, it is usually around 7 to 10 days.
• For H. pylori eradication in combination with other medications, it may be prescribed for 14 days.

What is Klarim used for?

Klarim is an antibiotic used to treat various infections caused by bacteria. In adults, it's used for chest infections like bronchitis and pneumonia, sinus infections, and throat infections. It also treats skin infections and a type of lung infection in people with advanced HIV. In children, Klarim is used for throat infections, pneumonia, sinus infections, ear infections, and skin infections. It's also used to prevent a chest infection in children with advanced HIV.

How long does it take for Klarim to start working?

Klarim, an antibiotic, starts working quickly, but it's crucial to finish the entire course of treatment for best results. The medicine reaches its maximum levels in your body within a few days or hours, depending on which type you're taking: * Suspension (250 mg every 12 hours): 2-3 days * 1000 mg extended-release tablets: 5-8 hours * 500 mg extended-release tablets: 5-6 hours

Is Klarim effective?

Klarim is a medicine that can help treat infections caused by bacteria. When doctors know what kind of bacteria is causing the infection, they can use that information to decide if Klarim is the right medicine to use. They also consider how often certain types of bacteria cause infections in their area and how well different medicines work against those bacteria when making treatment decisions.

How does one know if Klarim is working?

Klarim is a powerful antibiotic that has been used effectively to treat infections caused by bacteria. In one study, 88% of patients taking Klarim improved or were cured of their infection. This study involved 223 patients. Another study showed that Klarim reduced the risk of a type of bloodstream infection called MAC bacteremia by 69% compared to people who took a placebo. Lastly, 88% of patients treated with Klarim saw clinical improvement in a third study. These results were similar to patients treated with a cephalosporin, a different type of antibiotic. Overall, the results show that Klarim is effective for treating bacterial infections.

How does Klarim work?

Klarim, an antibiotic, enters body tissues and fluids easily. It builds up more inside cells than in the bloodstream. 

 It binds to the 50S ribosomal subunit of bacteria, preventing the formation of proteins necessary for the bacteria’s growth and survival. Without the ability to produce proteins, the bacteria cannot replicate or repair themselves, leading to their death or inhibition.

Klarim primarily targets Gram-positive bacteria and some Gram-negative bacteria, making it effective in treating respiratory infections, skin infections, and certain types of bacterial stomach infections (like H. pylori). It is often used in combination with other antibiotics for more effective treatment, especially in cases of resistant bacteria.

Who should avoid taking Klarim?

**Important Warnings:** * **Allergic reactions:** Klarim can cause severe allergic reactions, such as skin rashes, swelling, and difficulty breathing. Stop taking it and seek immediate medical help if you experience any of these symptoms. * **Heart problems:** Klarim can prolong your heartbeat and increase the risk of arrhythmias (irregular heartbeats). This is especially important if you have existing heart conditions. * **Liver damage:** Klarim can damage your liver, leading to yellowing of the skin or eyes, dark urine, and nausea. If you experience these symptoms, stop taking the medication and consult your doctor. **Medications to Avoid:** Klarim should not be taken with certain other medications, as it can increase their side effects: * Lomitapide, lovastatin, and simvastatin (cholesterol-lowering drugs) * Ergotamine and dihydroergotamine (migraine medications) * Lurasidone (antipsychotic medication) * Colchicine (gout medication), especially if you have kidney or liver problems

Can I take Klarim with vitamins or supplements?

Klarim may interact with certain vitamins and supplements. Magnesium or calcium supplements can reduce its effectiveness, so take them separately. Probiotics might lower its efficacy, so it's best to take them a few hours apart. Klarim can also increase the effects of Vitamin K antagonists (e.g., warfarin), raising bleeding risk. Always consult a healthcare provider before using supplements with Klarim.

Can I take Klarim with other prescription drugs?

Klarim can interact with certain medications. It can increase the effects of some, like colchicine and disopyramide, which can be life-threatening. It can also increase the risk of muscle problems with some cholesterol-lowering drugs, like simvastatin. Additionally, it can cause dizziness and drowsiness when used with certain sedatives, like triazolam. Always consult your healthcare provider before taking Klarim with other medications.

Can Klarim be taken safely while pregnant?

If you are pregnant, it is best to avoid taking Klarim unless there are no other treatment options. If you do become pregnant while taking Klarim, talk to your doctor about the potential risks to your unborn baby.

Can Klarim be taken safely while breastfeeding?

A breastfeeding mother taking 250 mg of Klarim twice a day passes on a small amount of the drug (136 mcg/kg/day) to her baby through breast milk. This is less than 2% of the dose she takes and less than 1% of the dose recommended for children over 6 months old. A study found that breastfed babies of mothers taking Klarim had similar side effects as babies of mothers taking amoxicillin.

Is Klarim safe for the elderly?

**For older adults with kidney problems:** * The medication's dosage may need to be adjusted. * They may be more likely to have an irregular heartbeat. * The medication may build up in their blood more than usual. **For older adults taking calcium channel blockers:** * Most reports of kidney problems have been in people 65 or older. **For older adults taking Klarim:** * They may be more likely to experience toxic effects from colchicine, especially if they also have kidney problems.

How should I store Klarim?

* Don't put the mixed suspension in the fridge. * Keep the mixed suspension at room temperature (between 59° and 86°F) for up to 14 days. * Keep the suspension before mixing it with water below 77°F.

Does Klarim make people tired or drowsy?

Constitutional side effects such as fatigue, sleepiness, or weakness are uncommon with Klarim and occur in less than 1 in 10 people. Fatigue or weakness has been reported but is not a frequent side effect.

If you experience these symptoms while taking Klarim, rest and stay hydrated. Avoid tasks requiring alertness, such as driving, if sleepiness occurs. If the side effects are severe, persistent, or impact daily activities, consult your healthcare provider.

Does Klarim cause stomach upset?

Gastrointestinal side effects are common with Klarim, with nausea, vomiting, abdominal pain, and diarrhea being frequently reported. These effects occur in up to 10% of people.

If you experience these side effects, take the medication with food to help reduce stomach upset. Staying hydrated is crucial, especially if diarrhea or vomiting occurs, to prevent dehydration. Avoid foods that may worsen symptoms, like spicy or greasy meals. If symptoms are severe, persistent, or include signs of a more serious issue (e.g., bloody diarrhea), contact your healthcare provider immediately.

Does Klarim affect sleep?

Sleep disturbances, such as insomnia, are uncommon with Klarim and occur in less than 1 in 10 people. While rare, some individuals may experience difficulty falling or staying asleep.

If you experience sleep disturbances while taking Klarim, try maintaining a consistent bedtime routine, avoiding caffeine or stimulating activities in the evening, and creating a relaxing sleep environment. If the issue persists or significantly impacts your daily life, consult your healthcare provider.

Does Klarim make it hard to think or concentrate?

Cognitive side effects, such as difficulty concentrating, thinking, remembering, sleepiness, or weakness, are uncommon with Klarim and occur in less than 1 in 10 people. Rarely, individuals may report confusion or dizziness as part of its side effect profile.

If you experience cognitive side effects while taking Klarim, avoid activities requiring focus, such as driving or operating machinery, until the symptoms resolve. Rest and stay hydrated. If the symptoms persist, worsen, or interfere with daily activities, consult your healthcare provider.

Does Klarim affect mood?

Mental health side effects such as mood swings, anxiety, or agitation are rare with Klarim and occur in less than 1 in 10 people. In very uncommon cases, symptoms like confusion, hallucinations, or abnormal thoughts have been reported, but these are not frequently experienced.

If you experience mental health side effects while taking Klarim, stay calm and inform your healthcare provider promptly. They may assess whether the medication is the cause and decide whether to adjust the treatment.

Does Klarim interfere with sexual function?

Sexual side effects, such as loss of libido or difficulty getting an erection, are extremely rare with Klarim and occur in less than 1 in 10 people. These effects are not commonly reported and are not considered a significant part of the medication's side effect profile.

If you experience sexual side effects while taking Klarim, consult your healthcare provider. They can assess whether the medication is contributing to the issue and may suggest alternatives or supportive measures.

Does Klarim affect appetite?

Klarim may affect your appetite. More than 1 out of 10 people taking this medicine lost their appetite. If you have any appetite changes, talk to your doctor.

Does Klarim cause weight gain?

Klarim can cause weight changes in animals, including weight loss in mothers and their offspring. However, the frequency of weight changes in humans taking Klarim is not known from the information provided. If you experience any weight changes while taking Klarim, consult your healthcare professional for advice.

Does Klarim cause headaches?

Headache is a rare side effect of Klarim, a medication used to treat infections. If you experience a headache while taking Klarim, it's important to talk to your doctor to rule out any other potential causes and determine if you need to stop taking the medication.

Does Klarim limit driving?

Klarim can make you feel dizzy, lightheaded, confused, or disoriented. If you experience any of these side effects, stop driving and call your doctor right away.

What are Klarim possible harms and risks?

The most common side effects are stomach pain, diarrhea, nausea, vomiting, and a bad taste in the mouth. Other side effects include indigestion, abnormal liver function tests, allergic reactions, yeast infections, headaches, trouble sleeping, and rash. Serious side effects include severe allergic reactions, heart rhythm problems, liver damage, and worsening of myasthenia gravis (a muscle weakness disorder). In one study, 3.5% of patients stopped taking the drug due to side effects. Liver problems, which can be serious but usually go away, have been reported. In rare cases, liver failure has been linked to other health conditions or medications.