ematra (TRETINOIN)
What is Ematra?
Ematra is used to treat acute promyelocytic leukemia (APL), a type of cancer with too many immature blood cells. It works by slowing or stopping the growth of cancer cells, causing them to develop into normal blood cells. Ematra is a retinoid and is typically used when other chemotherapy treatments have not been effective.
What is the usual dose of Ematra?
The recommended dosage of Ematra for adults and children over 1 year of age is 22.5 mg/m2 taken orally twice daily. Treatment continues until complete remission is documented, or for a maximum of 90 days. Always follow your doctor's specific instructions regarding dosage.
How do I take Ematra?
Take Ematra capsules with a meal, swallowing them whole with water. Do not chew, dissolve, or open the capsules. Consult your doctor about any specific food restrictions, such as grapefruit, which may interact with the medication.
For how long do I take Ematra?
Ematra is typically used for up to 90 days or until complete remission of acute promyelocytic leukemia is achieved. The exact duration may vary based on individual response and medical advice.
What is Ematra used for?
Ematra is indicated for the treatment of acute promyelocytic leukemia (APL), characterized by the presence of the t(15;17) translocation or PML/RARα gene expression. It is used in patients who are refractory to or have relapsed from anthracycline chemotherapy or for whom such chemotherapy is contraindicated.
How long does it take for Ematra to start working?
Ematra typically starts working within the first month of treatment, with the median time to complete remission being between 40 and 50 days. However, individual responses may vary, and regular monitoring by a healthcare provider is essential.
Is Ematra effective?
Ematra has been evaluated in clinical studies involving patients with acute promyelocytic leukemia (APL). It has shown effectiveness in inducing remission in both previously treated and untreated patients. The median time to complete remission was between 40 and 50 days, demonstrating its efficacy in treating APL.
How does one know if Ematra is working?
The benefit of Ematra is evaluated through regular monitoring by healthcare professionals. This includes checking for remission of acute promyelocytic leukemia symptoms and monitoring for side effects. Regular blood tests and clinical assessments help ensure the treatment is effective and safe.
How does Ematra work?
Ematra works by inducing the differentiation of immature blood cells into normal, mature cells. It decreases the proliferation of cancer cells in acute promyelocytic leukemia (APL), helping to achieve remission. The exact mechanism is not fully understood, but it involves altering gene expression to promote cell maturation.
Who should avoid taking Ematra?
Ematra can cause severe side effects, including embryo-fetal toxicity and differentiation syndrome. It is contraindicated in pregnant women due to the risk of birth defects. Patients should be monitored for symptoms of differentiation syndrome and leukocytosis. Avoid use with certain medications and supplements, such as Vitamin A and anti-fibrinolytic agents.
Can I take Ematra with vitamins or supplements?
Avoid using Vitamin A supplements while taking Ematra, as this can lead to Vitamin A-related adverse reactions. Always inform your healthcare provider about any supplements you are taking to prevent potential interactions.
Can I take Ematra with other prescription drugs?
Ematra interacts with strong CYP3A inhibitors, which can increase its plasma concentration and risk of adverse reactions. Avoid coadministration with strong CYP3A inducers, as they may reduce its efficacy. Also, avoid using it with other products that can cause intracranial hypertension, such as tetracyclines.
Can Ematra be taken safely while pregnant?
Ematra is contraindicated during pregnancy due to the risk of embryo-fetal loss and malformations. It is a retinoid, and exposure during pregnancy increases the risk of major congenital malformations and spontaneous abortions. Females of reproductive potential must use two effective methods of contraception during treatment and for 1 month after the last dose.
Can Ematra be taken safely while breastfeeding?
Due to the potential for serious adverse reactions in breastfed infants, women are advised not to breastfeed during treatment with Ematra and for 1 week after the last dose. Consult your healthcare provider for personalized advice.
Is Ematra safe for the elderly?
In clinical studies, 21% of patients were 60 years and older, and no overall differences in safety or effectiveness were observed between these patients and younger patients. However, elderly patients should be monitored closely for side effects, and treatment should be tailored to their specific health needs.
How should I store Ematra?
Store Ematra capsules at room temperature, between 20ºC to 25ºC (68ºF to 77ºF). Keep the bottle tightly closed and protect it from light. Ensure it is out of reach of children and dispose of it properly through a take-back program if no longer needed.
Does Ematra make people tired or drowsy?
Common constitutional side effects of Ematra include extreme tiredness and weakness. If you experience these symptoms, it's important to inform your doctor. They may adjust your treatment or provide supportive care to manage these side effects.
Does Ematra cause stomach upset?
Common gastrointestinal side effects of Ematra include nausea, vomiting, abdominal pain, and diarrhea. Nausea and vomiting occur in about 57% of patients. If you experience these symptoms, contact your doctor. They may adjust your treatment or provide medications to help manage these side effects.
Does Ematra affect sleep?
Insomnia is a reported side effect of Ematra, occurring in about 14% of patients. If you experience difficulty sleeping, consult your doctor. They may suggest lifestyle changes, adjust your medication, or provide treatment to help manage this side effect.
Does Ematra make it hard to think or concentrate?
Cognitive side effects of Ematra can include confusion, occurring in about 11% of patients. If you experience difficulty concentrating or confusion, consult your doctor. They may adjust your treatment or provide strategies to help manage these cognitive effects.
Does Ematra affect mood?
Mental health side effects of Ematra can include depression and anxiety, each occurring in about 14% and 17% of patients, respectively. If you experience mood changes or anxiety, it's important to inform your doctor. They may adjust your treatment or provide support to manage these effects.
Does Ematra affect appetite?
Ematra can cause changes in appetite, including anorexia, which occurs in about 17% of patients. If you experience a significant change in appetite, contact your doctor. They may adjust your treatment or provide dietary advice to help manage this side effect.
Does Ematra cause weight gain?
Ematra can cause weight changes, with weight increase occurring in about 23% of patients and weight decrease in 17%. If you notice significant weight changes, consult your doctor. They may adjust your treatment or provide dietary and lifestyle advice to help manage these changes.
Does Ematra cause headaches?
Headaches are a common side effect of Ematra, occurring in about 86% of patients. If you experience severe or persistent headaches, inform your doctor. They may adjust your treatment or recommend medications to help manage the pain.
Does Ematra limit driving?
Ematra may cause dizziness or severe headaches, which can impair your ability to drive. If you experience these symptoms, avoid driving or operating machinery until you know how the medication affects you. Always prioritize safety and consult your doctor for personalized advice.
Is it safe to exercise while taking Ematra?
Ematra may cause dizziness or severe headaches, which could limit your ability to exercise safely. If you experience these symptoms, avoid activities that require alertness, such as exercising, until you know how the medication affects you. Consult your doctor for personalized advice.
What are Ematra possible harms and risks?
Common side effects of Ematra include headache (86%), fever (83%), skin dryness (77%), bone pain (77%), and nausea/vomiting (57%). Serious adverse effects include differentiation syndrome, leukocytosis, and thromboembolic events. If you experience any severe symptoms, contact your doctor immediately.
Available in 2 variations
Ematra Capsule
Ematra Capsule
Tretinoin (10mg)
bottle of 100 capsules
Ematra 10mg Capsule 100s
Tretinoin (10mg)
strip of 100 tablets
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