It is important to take Depgesic MR Forte 500mg50mg325mg Tablet with food to prevent stomach upset Follow your doctors instructions and take it regularly as prescribed Do not exceed the recommended dosage or use it for a longer period without consulting your doctor Common side effects may include nausea vomiting heartburn stomach pain diarrhea loss of appetite and dry mouth If these side effects are bothersome or persist inform your doctor They may be able to suggest ways to minimize or prevent these side effects Before taking this medicine inform your doctor if you have any heart kidney or liver problems as it may not be suitable for everyone It is also important to disclose all other medications you are taking to ensure its safety Pregnant and breastfeeding mothers should consult with their doctors before using this medicine