calsunate

Calsunate 60mg Injection contains Artesunate, which is a medication primarily utilized for the treatment of malaria, particularly in severe cases. Belonging to the artemisinin class of medications holds a place on the World Health Organization's List of Essential Medicines.

It functions as a prodrug, rapidly converting to its active form, dihydroartemisinin (DHA). This transformation generates reactive oxygen species, inducing oxidative stress and causing damage to malarial proteins. Additionally, it inhibits the essential Plasmodium falciparum exported protein 1 (EXP1), reducing parasite glutathione levels.

While generally well-tolerated, common side effects may include a slow heartbeat, allergic reactions, dizziness, and low white blood cell levels In severe cases, kidney failure requiring dialysis, hemoglobinuria (presence of hemoglobin in urine), and jaundice have been reported.

It is considered safe during pregnancy, particularly in the second and third trimesters, although caution is advised in the first trimester. It is generally safe for use in children, with adjustments in dosing for those under 20 kg. Notably, it should be avoided in newborns when combined with sulfadoxine/pyrimethamine due to potential effects on bilirubin.

In the event of a missed dose, it is crucial to consult with a healthcare professional for guidance on the appropriate course of action. The timing and severity of the missed dose will be considered to determine the most suitable response.

Available in 3 variations

Calsunate 60mg Injection

Artesunate (60mg)

vial of 1 Injection

MRP : ₹131

Calsunate DS Tablet

Artesunate (NA)

strip of 6 tablets

MRP : ₹121

Calsunate 50mg Tablet

Artesunate (50mg)

strip of 4 tablets

MRP : ₹59

Related Faqs

Where does Calsunate come from?

Artemisinin the key ingredient in various antimalarial medications is obtained from the Artemisinin tree This remarkable compound has proven to be highly effective in treating malaria and has played a pivotal role in reducing the global burden of this deadly disease The Artemisinin tree scientifically known as Artemisia annua is native to Asia and has been used in traditional Chinese medicine for centuries The leaves and flowers of this plant contain high concentrations of Artemisinin making it a valuable resource in the fight against malaria The process of obtaining Artemisinin involves extracting the compound from the leaves of the Artemisinin tree Once the leaves are harvested they are subjected to a series of purification and extraction techniques to isolate the precious Artemisinin molecules These molecules are then further processed to produce various formulations of antimalarial medications including tablets injectables and syrup The availability of Artemisininbased medicines has revolutionized malaria treatment and contributed significantly to the decline in malariarelated deaths worldwide Artemisininbased combination therapy ACT which combines Artemisinin with other antimalarial drugs is considered the most effective treatment for uncomplicated malaria This combination therapy not only ensures a rapid reduction in parasite levels but also reduces the risk of developing drug resistance The affordability accessibility and efficacy of Artemisininbased medications have made them a cornerstone of malaria control efforts globally However due to concerns of resistance development it is vital to ensure the sustainable supply of highquality Artemisinin encouraging research into alternative sources and production methods The Artemisinin tree continues to be a valuable asset in the ongoing battle against malaria highlighting natures role in providing lifesaving solutions to global health challenges

How does Falcimax work?

The mechanism of action involves the generation of reactive molecules known as free radicals which effectively eradicate the malarial parasite specifically Plasmodium These free radicals have the ability to disrupt vital cellular processes within the parasite leading to its ultimate demise By generating these highly reactive species the drug displays a targeted approach to combating malaria ensuring that the parasite is specifically targeted while minimizing harm to the host organism This unique mode of action sets it apart from other antimalarial medications making it an effective and valuable tool in the fight against malaria The production of free radicals effectively harnesses the oxidative power of the drug allowing it to selectively destroy Plasmodium and halt the progression of the disease By attacking the parasite at its core this drug offers a promising approach to malaria treatment and prevention and continues to play a pivotal role in global efforts to control this devastating disease

How does Maxinate work?

The mechanism of action of this substance involves the generation of free radicals which effectively exterminate the Plasmodium parasite responsible for causing malaria By producing these highly reactive particles this substance exhibits a potent antimalarial effect The free radicals generated upon administration of this substance target the vital structures and metabolic processes of the malarial parasite leading to its eradication By disrupting the parasites normal functioning this substance effectively halts the progression of the disease and promotes the elimination of the infection This unique mechanism of action sets this substance apart as an efficient and effective option in the fight against malaria Its ability to specifically target and eliminate the Plasmodium parasite showcases its potential to combat this widespread and lifethreatening disease By harnessing the power of free radicals this substance offers a promising strategy for inhibiting the growth and survival of the malarial parasite ultimately contributing to the global efforts to control and eliminate malaria

Is Genuate banned in India?

In India the availability of certain medications is regulated requiring a doctors prescription to obtain them This measure ensures the safety and appropriate usage of these drugs By implementing this system the government aims to protect the public from potential risks associated with selfmedication and inappropriate use of medications While this may seem inconvenient for some it is a necessary step to safeguard the health and wellbeing of individuals in the country Having a doctors prescription serves several purposes Firstly it helps to prevent the misuse or abuse of medications that can have severe consequences on ones health Secondly it allows medical professionals to evaluate the patients condition and history ensuring that the prescribed medication aligns with their specific needs Additionally prescriptions enable doctors to monitor the patients progress and make any necessary adjustments to the treatment plan The process of obtaining a prescription is relatively straightforward Individuals seeking medication must schedule an appointment with a qualified healthcare provider who will assess their medical condition and recommend appropriate treatment Following the consultation the doctor will issue a prescription that can be presented to a licensed pharmacist to obtain the prescribed medication This system ensures that individuals receive the appropriate treatment and minimizes the risks associated with selfdiagnosis and selfmedication

Is T Nate banned in India?

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How does Artesar work?

The mechanism of action of this particular compound involves the production of free radicals which have the capacity to effectively target and eliminate the malarial parasite known as Plasmodium By generating these highly reactive molecules this substance is able to disrupt vital processes within the parasite ultimately leading to its demise The production of free radicals is a critical step in the chain of events that result in the destruction of the malarial parasite This compounds unique ability to generate these radicals distinguishes it as an effective weapon against the Plasmodium parasite offering a promising approach for combating malaria As the free radicals are unleashed they directly attack specific targets within the parasite such as key proteins or cell membranes interfering with essential biological processes Consequently the malarial parasite is unable to survive leading to its complete eradication This innovative mechanism of action places this compound at the forefront of antimalarial treatments showcasing its potential for contributing to the global efforts in controlling and ultimately eliminating malaria

Written By:

DRx. Ayush RajMBA in Pharmaceuticals Marketing and Management

Published At: Dec 10, 2024

Updated At: Dec 30, 2024

Reviewed By:

DRx Ashwani SinghMaster in Pharmacy

Published At: Dec 10, 2024

Updated At: Dec 30, 2024

Disclaimer : This information is not a substitute for medical advice. Consult your healthcare provider before making any changes to your treatment . Do not ignore or delay professional medical advice based on anything you have seen or read on Medwiki.

Find us at:

calsunate

Prescription Required

Manufacturer :

Calibar Pharmaceuticals

Composition :

artesunate

MRP :

₹59 - ₹131