Aprepit Kit (APREPITANT)
What is Aprepit kit?
Aprepit kit is a prescription medicine used to prevent nausea and vomiting, not to treat it once it's already started. It's given along with other medications to stop chemotherapy-related nausea and vomiting in people 12 and older. Adults also use it to prevent nausea and vomiting after surgery.
Chemotherapy is a cancer treatment using strong drugs. Nausea is the feeling of sickness in your stomach. Vomiting is throwing up.
Aprepit kit doesn't cure these problems; it helps prevent them from happening in the first place. How it works inside the body isn't explained in the information provided.
What is the usual dose of Aprepit kit?
Aprepit kit is used to prevent nausea and vomiting. For adults and children 12 and older getting chemotherapy, the typical dose is 125mg on the first day, then 80mg on days two and three. If chemo isn't on days two and three, take the 80mg dose in the morning. To prevent nausea and vomiting after surgery, the dose is 40mg within 30 hours before the surgery. *Chemotherapy* is a cancer treatment using drugs. *Hepatic impairment* means the liver isn't working perfectly. *Renal impairment* means the kidneys aren't working perfectly. The dosage usually doesn't need to be changed for mildly or moderately impaired livers, or for any level of kidney impairment.
How do I take Aprepit kit?
Aprepit kit is a medicine.
For chemotherapy: On day 1, take one 125 mg (milligram – a unit of weight) white and pink capsule an hour before your chemo treatment. On days 2 and 3, take one 80 mg white capsule an hour before chemo, or in the morning if you don't have chemo that day. Chemotherapy is cancer treatment using drugs.
For surgery: Your doctor will tell you if you need to take a 40 mg capsule within 3 hours before your surgery. Surgery is a medical operation.
You can take Aprepit kit with or without food if you're having chemotherapy. There are no other special diet instructions.
For how long do I take Aprepit kit?
Aprepit kit is typically used only for the first three days of chemotherapy cycles or as a single dose before surgery. Chronic or continuous use is not recommended as it hasn’t been studied and may increase the risk of drug interactions.
What disease or symptom is Aprepit kit used for?
Aprepit kit is indicated for preventing nausea and vomiting associated with highly and moderately emetogenic chemotherapy (including cisplatin-based regimens) and for the prevention of postoperative nausea and vomiting in adults.
How long does it take for Aprepit kit to start working?
Aprepit kit begins working within a few hours, effectively preventing nausea and vomiting during chemotherapy or after surgery. It provides protection for both acute (0–24 hours) and delayed (25–120 hours) phases of emesis.
Is Aprepit kit effective?
Aprepit kit's effectiveness in preventing nausea and vomiting caused by strong (highly emetogenic chemotherapy or HEC) or moderately strong (moderately emetogenic chemotherapy or MEC) chemotherapy has been shown in a study of children 12 and older. The study included 95 children in this age group, along with younger children. Aprepit kit was given with ondansetron (another anti-nausea medicine) and sometimes dexamethasone (a steroid that can also help with nausea). Side effects were similar to those seen in adults. However, how well Aprepit kit works in children under 6 months old isn't known. * **Highly emetogenic chemotherapy (HEC):** Chemotherapy drugs very likely to cause severe nausea and vomiting. * **Moderately emetogenic chemotherapy (MEC):** Chemotherapy drugs somewhat likely to cause nausea and vomiting. * **Ondansetron:** A medicine to prevent and treat nausea and vomiting. * **Dexamethasone:** A steroid medicine with many uses, including reducing nausea and vomiting.
How do I know if Aprepit kit is working?
The studies measured how well the drug prevented nausea and vomiting after chemotherapy and surgery. **Chemotherapy Study:** The main goal was to see how many patients had *no vomiting, retching (the urge to vomit), or needed extra anti-nausea medicine* within 25-120 hours after chemo (this is called a "complete response"). They also looked at complete response in the first 24 hours and up to 120 hours, and just the absence of vomiting up to 120 hours. **Surgery Study:** The main goal was to see how many patients had *no vomiting* and a complete response (no vomiting, no extra medicine) in the first 24 hours after surgery. They also checked for no vomiting in the first 48 hours. In short, the studies measured the drug's success in preventing nausea and vomiting at different times after treatment.
How does Aprepit kit work?
Aprepit kit stops nausea and vomiting. It does this by blocking neurokinin, a chemical in the brain that causes these symptoms. Doctors usually prescribe it for three days during chemotherapy. However, the exact dose and how long you take it will depend on your doctor's instructions. It's very important to take it exactly as prescribed – don't change the dose or how often you take it. * **Neurokinin:** A type of chemical messenger in the brain and body involved in sending signals, including those related to nausea and vomiting. * **Chemotherapy:** A type of cancer treatment using drugs to kill cancer cells.
Who should avoid taking Aprepit kit?
Aprepit kit is contraindicated in individuals allergic to its components or those taking medications like Pimozide due to the risk of severe drug interactions. Women using hormonal contraceptives should use alternative methods during and for 1 month after taking Aprepit kit.
Can I take Aprepit kit with other prescription drugs?
Aprepit kit interacts significantly with other medications. It affects how the liver processes some drugs. Taking it with strong CYP3A4 inhibitors (drugs that slow down liver processing, like ketoconazole and diltiazem) can raise Aprepit kit levels in your blood, increasing side effects. Conversely, strong CYP3A4 inducers (drugs that speed up liver processing, like rifampin) can lower Aprepit kit's effectiveness. Aprepit kit can also weaken warfarin (a blood thinner), needing closer monitoring of your blood clotting levels (INR). It might also make hormonal birth control less effective, so a backup method is advised. Never take Aprepit kit with pimozide (a psychiatric medication) as it's dangerous. Always tell your doctor about all medications you take before starting Aprepit kit.
Can Aprepit kit be taken safely while pregnant?
Limited studies exist on Aprepit kit’s safety during pregnancy. Animal studies did not show fetal harm, but it is generally recommended to use Aprepit kit only if clearly needed during pregnancy.
Can Aprepit kit be taken safely while breastfeeding?
It is unknown whether Aprepit kit is excreted in human milk. Breastfeeding women should weigh the benefits of the medication against potential risks to the infant and consult their doctor before use.
Is Aprepit kit safe for the elderly?
Clinical studies indicate no major differences in response between older and younger patients. However, elderly individuals should use it cautiously, especially if they have other medical conditions or take multiple medications.
How should I store Aprepit kit?
Capsules should be stored at room temperature, away from moisture and heat. Oral suspensions must be refrigerated and used within 72 hours of preparation.
Does Aprepit kit make people tired or drowsy?
Fatigue is reported in up to 13% of users. If significant drowsiness occurs, patients should avoid operating machinery or driving and inform their healthcare provider
Does Aprepit kit cause stomach upset?
Diarrhea (9%), nausea, and abdominal pain (6%) are common side effects. Drinking plenty of fluids and eating light meals can help, but persistent symptoms should be discussed with a doctor.
Does Aprepit kit affect sleep?
Most people tolerate this medicine well and difficulty sleeping is not commonly reported. However, everybody can respond differently to medicines. Always track any changes you notice and let your doctor know when new symptoms are concerning - this will help make sure this medicine is right for you.
Does Aprepit kit make it hard to think or concentrate?
Cognitive side effects like dizziness (5%) have been reported. Patients experiencing difficulty concentrating should avoid activities requiring alertness and consult their doctor.
Does Aprepit kit affect mood?
Anxiety is a rare side effect and may occur in some individuals. Seek medical advice if mood changes become noticeable or problematic.
Does Aprepit kit interfere with sexual function?
Sexual side effects are not commonly associated with Aprepit kit use. However, if any unusual changes occur, they should be discussed with a doctor.
Does Aprepit kit affect appetite?
Decreased appetite is reported in about 5% of users. Maintaining proper nutrition during treatment is important, and any significant weight loss should be reported to a healthcare provider.
Does Aprepit kit cause weight gain?
Weight gain is not commonly reported as a side effect of Aprepit kit. Patients should maintain a balanced diet during treatment.
Does Aprepit kit cause headaches?
Aprepit kit can cause headaches in children aged 6 months to 17 years. If your child gets a headache while taking Aprepit kit, you should contact their doctor. A headache is a pain in the head. Aprepit kit is a medicine.
Does Aprepit kit limit driving?
Aprepit kit can make you feel dizzy and weak. If this happens, don't drive. Dizziness means feeling unsteady or lightheaded, like you might fall. Weakness refers to a lack of strength or feeling tired. Driving while experiencing these side effects could be dangerous to you and others. It's important to follow your doctor's instructions and be aware of how this medication affects you. If you experience these side effects, consider resting and avoiding activities that require alertness until they subside. Always talk to your doctor or pharmacist if you have concerns about side effects.
Is it safe to drink alcohol while taking Aprepit kit?
Drinking alcohol while taking Aprepit kit can worsen side effects like dizziness or nausea. It’s best to avoid alcohol during treatment for optimal safety.
Is it safe to drink coffee or tea while taking Aprepit kit?
Coffee and tea do not interact with Aprepit kit, and moderate consumption is safe. Patients should monitor their tolerance if caffeine causes increased side effects like anxiety.
Is it safe to exercise while taking Aprepit kit?
Exercise is generally safe, but patients should avoid strenuous activity if experiencing side effects like dizziness or fatigue. Moderate exercise can help maintain energy levels during treatment.
What are Aprepit kit possible harms and risks?
Aprepit kit's most common side effects are tiredness, diarrhea, weakness, indigestion, stomach pain, hiccups, low white blood cell count (meaning your body's infection fighters are reduced), and dehydration. In studies, tiredness (fatigue), diarrhea, weakness (asthenia), indigestion (dyspepsia), stomach pain (abdominal pain), and hiccups were reported in a significant percentage of people. Low white blood cell counts and dehydration were less common. Serious side effects needing immediate medical help include allergic reactions like hives, rash, itching, severe skin reactions (peeling or blisters), and trouble breathing or swallowing. If you experience any of these, seek medical attention right away. Always talk to your doctor about any concerns or side effects.
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