Liver and Spleen Damage from Dengue: Pathogenesis
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What are some common preventive measures that individuals can take to reduce the risk of dengue virus infection?
- Dengue virus, transmitted by mosquitoes, enters the human body through infected mosquito bites.
- The virus primarily infects white blood cells, specifically monocytes and macrophages, crucial for the immune response.
- Infected cells spread the virus to various body parts, including the liver and spleen.
- The liver filters blood and eliminates toxins, while the spleen filters blood and removes old or damaged red blood cells.
- Dengue virus causes inflammation and damage to liver and spleen cells, triggering an immune response.
- Immune cells release cytokines and chemokines, attracting more immune cells and causing further organ damage.
- Symptoms of liver and spleen damage include abdominal pain, nausea, vomiting, and jaundice.
- Severe cases may lead to liver failure and bleeding disorders.
- Preventive measures, such as using mosquito repellent and wearing protective clothing, are crucial to avoid dengue virus infection.
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